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3EKW

Crystal structure of the inhibitor Atazanavir (ATV) in complex with a multi-drug resistance HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) Refer: FLAP+ in citation.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE PO4 A 505
ChainResidue
AARG8

site_idAC2
Number of Residues23
DetailsBINDING SITE FOR RESIDUE DR7 B 100
ChainResidue
BARG8
BLEU23
BASP25
BGLY27
BALA28
BASP29
BVAL48
BGLY49
BILE50
BPRO81
AARG8
BALA82
BHOH528
BHOH529
BHOH534
BHOH569
AASP25
AGLY27
AASP29
AVAL48
AGLY49
AILE50
AHOH508

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 B 502
ChainResidue
BGLY73
BTHR74
BASN88
BGLN92
BHOH520
BHOH554
BHOH566

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO4 B 503
ChainResidue
AHIS69
ALYS70
BPRO1

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL
ChainResidueDetails
AALA22-LEU33

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094
ChainResidueDetails
AASP25
BASP25

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by viral protease => ECO:0000250
ChainResidueDetails
APHE99
BPHE99

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
AASP25
ATHR26

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
BASP25
BTHR26

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
AASP25

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
BASP25

221716

PDB entries from 2024-06-26

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