3EJQ

Golgi alpha-Mannosidase II in complex with 5-substitued swainsonine analog: (5R)-5-[2'-oxo-2'-(4-methylphenyl)ethyl]-swainsonine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0003824	molecular_function	catalytic activity
A	0004559	molecular_function	alpha-mannosidase activity
A	0004572	molecular_function	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
A	0005783	cellular_component	endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005795	cellular_component	Golgi stack
A	0005975	biological_process	carbohydrate metabolic process
A	0006013	biological_process	mannose metabolic process
A	0006486	biological_process	protein glycosylation
A	0006491	biological_process	N-glycan processing
A	0015923	molecular_function	mannosidase activity
A	0016020	cellular_component	membrane
A	0016063	biological_process	rhodopsin biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0030246	molecular_function	carbohydrate binding
A	0035010	biological_process	encapsulation of foreign target
A	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000250

Chain	Residue	Details
A	ASP204

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS90
A	ASP92
A	ASP204
A	HIS471

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 793

Chain	Residue	Details
A	HIS90	metal ligand
A	ASP92	metal ligand
A	ASP204	covalently attached, metal ligand, nucleofuge, nucleophile
A	ASP341	activator, increase nucleophilicity, proton acceptor, proton donor
A	HIS471	metal ligand

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