3EJ5

complex of Ricin A chain and pyrimidine-based inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0017148	biological_process	negative regulation of translation
X	0030598	molecular_function	rRNA N-glycosylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EJ5 X 300

Chain	Residue
X	TYR80
X	VAL81
X	GLY121
X	TYR123
X	ILE172
X	SER176
X	GLU177
X	ARG180

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Functional Information from PROSITE/UniProt

site_id	PS00275
Number of Residues	17
Details	SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. IqMIsEAARFQyIEgeM

Chain	Residue	Details
X	ILE172-MET188

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P84531

Chain	Residue	Details
X	GLU177
X	ARG180
X	TYR80
X	TYR123

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
X	ILE8

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
X	GLY15
X	GLY50
X	ASN141
X	ASN195

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8780513, ECO:0007744|PDB:1OBT

Chain	Residue	Details
X	GLY121
X	TYR80

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1368517

Chain	Residue	Details
X	ASN10

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:1368517

Chain	Residue	Details
X	ASN236

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