3EFO
Crystal Structure of the mammalian COPII-coat protein Sec23/24 bound to the transport signal sequence of syntaxin 5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0030127 | cellular_component | COPII vesicle coat |
| A | 0030134 | cellular_component | COPII-coated ER to Golgi transport vesicle |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0070971 | cellular_component | endoplasmic reticulum exit site |
| A | 0072659 | biological_process | protein localization to plasma membrane |
| A | 0090110 | biological_process | COPII-coated vesicle cargo loading |
| A | 0090114 | biological_process | COPII-coated vesicle budding |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0030127 | cellular_component | COPII vesicle coat |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 766 |
| Chain | Residue |
| A | CYS61 |
| A | CYS66 |
| A | CYS85 |
| A | CYS88 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B1034 |
| Chain | Residue |
| B | CYS364 |
| B | CYS367 |
| B | CYS386 |
| B | CYS389 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 159 |
| Details | Repeat: {"description":"Gelsolin-like","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2NUP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YRD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EGD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KYN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KYX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 25 |
| Details | Region: {"description":"Zinc finger-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3EFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KYX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Motif: {"description":"IxM motif; signal for cargo packaging into COPII-coated vesicles","evidences":[{"source":"PubMed","id":"18843296","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
