3EEC

X-ray structure of human ubiquitin Cd(II) adduct

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 101

Chain	Residue
A	GLU64
A	HIS68
A	HOH107
A	HOH108

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 102

Chain	Residue
A	MET1
A	GLU16
A	ASP32
A	HOH109

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 103

Chain	Residue
A	GLU18
A	ASP21
A	LYS29
A	GLU18

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD A 104

Chain	Residue
A	ASP58

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 105

Chain	Residue
A	GLU24
A	ASP52

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD A 106

Chain	Residue
A	ASP39

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD B 201

Chain	Residue
B	GLU64
B	HIS68

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD B 202

Chain	Residue
B	MET1
B	GLU16
B	ASP32
B	HOH207

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD B 203

Chain	Residue
B	GLU18
B	GLU18
B	ASP21
B	LYS29
B	HOH208
B	HOH209

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD B 204

Chain	Residue
B	ASP58

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD B 205

Chain	Residue
B	GLU24
B	ASP52

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD B 206

Chain	Residue
B	ASP39

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
B	ARG54
B	ARG72
A	ARG54
A	ARG72

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Essential for function

Chain	Residue	Details
B	HIS68
A	HIS68

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291

Chain	Residue	Details
B	SER65
A	SER65

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457

Chain	Residue	Details
B	THR66
A	THR66

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
A	GLY76
B	GLY76

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
A	LYS6
B	LYS6

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
A	GLY76
B	GLY76

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
B	LYS11
B	LYS48
A	LYS11
A	LYS48

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
A	LYS27
B	LYS27

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
A	LYS29
B	LYS29

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
A	LYS33
B	LYS33

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
A	LYS63
B	LYS63

---