3EEB
Structure of the V. cholerae RTX cysteine protease domain
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE IHP A 210 |
| Chain | Residue |
| A | GLU27 |
| A | ARG182 |
| A | LYS183 |
| A | LYS195 |
| A | LYS200 |
| A | NA211 |
| A | HOH212 |
| A | HOH275 |
| A | HOH276 |
| A | HOH277 |
| A | HOH278 |
| A | THR28 |
| A | HOH279 |
| A | HOH281 |
| A | HOH285 |
| A | HOH286 |
| A | HOH288 |
| A | HOH303 |
| A | ARG29 |
| A | LYS54 |
| A | HIS55 |
| A | ARG85 |
| A | SER136 |
| A | SER169 |
| A | ARG171 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 211 |
| Chain | Residue |
| A | GLU27 |
| A | IHP210 |
| A | HOH284 |
| A | HOH286 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE IHP B 210 |
| Chain | Residue |
| B | GLY25 |
| B | GLU27 |
| B | THR28 |
| B | ARG29 |
| B | LYS54 |
| B | HIS55 |
| B | ARG85 |
| B | SER136 |
| B | SER169 |
| B | ARG171 |
| B | ARG182 |
| B | LYS183 |
| B | LYS195 |
| B | LYS200 |
| B | NA211 |
| B | HOH214 |
| B | HOH215 |
| B | HOH220 |
| B | HOH231 |
| B | HOH243 |
| B | HOH248 |
| B | HOH283 |
| B | HOH298 |
| B | HOH321 |
| B | HOH322 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 211 |
| Chain | Residue |
| B | GLU27 |
| B | IHP210 |
| B | HOH283 |
| B | HOH293 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: For cysteine protease activity => ECO:0000255|PROSITE-ProRule:PRU01107, ECO:0000269|PubMed:17698571 |
| Chain | Residue | Details |
| A | HIS91 | |
| B | HIS91 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile; for cysteine protease activity => ECO:0000255|PROSITE-ProRule:PRU01107, ECO:0000269|PubMed:17698571 |
| Chain | Residue | Details |
| A | CYS140 | |
| B | CYS140 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18845756, ECO:0000269|PubMed:19465933, ECO:0000269|PubMed:19620709, ECO:0007744|PDB:3EEB, ECO:0007744|PDB:3FZY, ECO:0007744|PDB:3GCD |
| Chain | Residue | Details |
| A | GLU27 | |
| B | LYS54 | |
| B | ARG85 | |
| B | SER136 | |
| B | SER169 | |
| B | ARG182 | |
| B | LYS195 | |
| B | LYS200 | |
| A | LYS54 | |
| A | ARG85 | |
| A | SER136 | |
| A | SER169 | |
| A | ARG182 | |
| A | LYS195 | |
| A | LYS200 | |
| B | GLU27 |
