3EEB
Structure of the V. cholerae RTX cysteine protease domain
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE IHP A 210 |
| Chain | Residue |
| A | GLU27 |
| A | ARG182 |
| A | LYS183 |
| A | LYS195 |
| A | LYS200 |
| A | NA211 |
| A | HOH212 |
| A | HOH275 |
| A | HOH276 |
| A | HOH277 |
| A | HOH278 |
| A | THR28 |
| A | HOH279 |
| A | HOH281 |
| A | HOH285 |
| A | HOH286 |
| A | HOH288 |
| A | HOH303 |
| A | ARG29 |
| A | LYS54 |
| A | HIS55 |
| A | ARG85 |
| A | SER136 |
| A | SER169 |
| A | ARG171 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 211 |
| Chain | Residue |
| A | GLU27 |
| A | IHP210 |
| A | HOH284 |
| A | HOH286 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE IHP B 210 |
| Chain | Residue |
| B | GLY25 |
| B | GLU27 |
| B | THR28 |
| B | ARG29 |
| B | LYS54 |
| B | HIS55 |
| B | ARG85 |
| B | SER136 |
| B | SER169 |
| B | ARG171 |
| B | ARG182 |
| B | LYS183 |
| B | LYS195 |
| B | LYS200 |
| B | NA211 |
| B | HOH214 |
| B | HOH215 |
| B | HOH220 |
| B | HOH231 |
| B | HOH243 |
| B | HOH248 |
| B | HOH283 |
| B | HOH298 |
| B | HOH321 |
| B | HOH322 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 211 |
| Chain | Residue |
| B | GLU27 |
| B | IHP210 |
| B | HOH283 |
| B | HOH293 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 368 |
| Details | Domain: {"description":"Peptidase C80","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For cysteine protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17698571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for cysteine protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17698571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18845756","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19465933","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19620709","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FZY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GCD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
