3EBM

Crystal structure of human translationally controlled tumour associated protein (hTCTP) mutant E12V

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000922	cellular_component	spindle pole
A	0003723	molecular_function	RNA binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005771	cellular_component	multivesicular body
A	0005829	cellular_component	cytosol
A	0005881	cellular_component	cytoplasmic microtubule
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0009615	biological_process	response to virus
A	0010507	biological_process	negative regulation of autophagy
A	0042981	biological_process	regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0070062	cellular_component	extracellular exosome
A	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A	2001234	biological_process	negative regulation of apoptotic signaling pathway
B	0000922	cellular_component	spindle pole
B	0003723	molecular_function	RNA binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005771	cellular_component	multivesicular body
B	0005829	cellular_component	cytosol
B	0005881	cellular_component	cytoplasmic microtubule
B	0006816	biological_process	calcium ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0009615	biological_process	response to virus
B	0010507	biological_process	negative regulation of autophagy
B	0042981	biological_process	regulation of apoptotic process
B	0043066	biological_process	negative regulation of apoptotic process
B	0070062	cellular_component	extracellular exosome
B	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
B	2001234	biological_process	negative regulation of apoptotic signaling pathway
C	0000922	cellular_component	spindle pole
C	0003723	molecular_function	RNA binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005771	cellular_component	multivesicular body
C	0005829	cellular_component	cytosol
C	0005881	cellular_component	cytoplasmic microtubule
C	0006816	biological_process	calcium ion transport
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0009615	biological_process	response to virus
C	0010507	biological_process	negative regulation of autophagy
C	0042981	biological_process	regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0070062	cellular_component	extracellular exosome
C	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
C	2001234	biological_process	negative regulation of apoptotic signaling pathway
D	0000922	cellular_component	spindle pole
D	0003723	molecular_function	RNA binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005771	cellular_component	multivesicular body
D	0005829	cellular_component	cytosol
D	0005881	cellular_component	cytoplasmic microtubule
D	0006816	biological_process	calcium ion transport
D	0006874	biological_process	intracellular calcium ion homeostasis
D	0009615	biological_process	response to virus
D	0010507	biological_process	negative regulation of autophagy
D	0042981	biological_process	regulation of apoptotic process
D	0043066	biological_process	negative regulation of apoptotic process
D	0070062	cellular_component	extracellular exosome
D	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
D	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS01002
Number of Residues	11
Details	TCTP_1 Translationally controlled tumor protein (TCTP) domain signature 1. IGGNASAEGPE

Chain	Residue	Details
A	ILE48-GLU58

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site_id	PS01003
Number of Residues	23
Details	TCTP_2 Translationally controlled tumor protein (TCTP) domain signature 2. FknyqFFIGEnmnp...DGmVAlldY

Chain	Residue	Details
A	PHE129-TYR151

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	408
Details	Region: {"description":"Required for reduction of TSC22D1 protein stability","evidences":[{"source":"PubMed","id":"18325344","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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