3E9I
Lysyl-tRNA synthetase from Bacillus stearothermophilus complexed with L-Lysine hydroxamate-AMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0140096 | molecular_function | catalytic activity, acting on a protein |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0140096 | molecular_function | catalytic activity, acting on a protein |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004824 | molecular_function | lysine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006412 | biological_process | translation |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016874 | molecular_function | ligase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0140096 | molecular_function | catalytic activity, acting on a protein |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004824 | molecular_function | lysine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016874 | molecular_function | ligase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0140096 | molecular_function | catalytic activity, acting on a protein |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1000 |
| Chain | Residue |
| A | GLU404 |
| A | GLU411 |
| A | ASN414 |
| A | XAH1001 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE XAH A 1001 |
| Chain | Residue |
| A | GLU255 |
| A | ARG260 |
| A | HIS261 |
| A | ASN262 |
| A | PHE265 |
| A | MET267 |
| A | GLU269 |
| A | TYR271 |
| A | GLU411 |
| A | HIS412 |
| A | ALA413 |
| A | ASN414 |
| A | PHE416 |
| A | GLU418 |
| A | GLY467 |
| A | ARG470 |
| A | ILE481 |
| A | HOH581 |
| A | MG1000 |
| A | GLY207 |
| A | ALA208 |
| A | ALA229 |
| A | GLU231 |
| A | ARG253 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1PE A 494 |
| Chain | Residue |
| A | ARG186 |
| A | ASP189 |
| A | SER190 |
| A | TYR193 |
| A | LEU194 |
| A | GLU195 |
| A | HOH545 |
| B | GLN182 |
| B | HOH977 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1100 |
| Chain | Residue |
| B | GLU404 |
| B | GLU411 |
| B | ASN414 |
| B | XAH1101 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE XAH B 1101 |
| Chain | Residue |
| B | GLY207 |
| B | ALA208 |
| B | ALA229 |
| B | GLU231 |
| B | ARG253 |
| B | GLU255 |
| B | ARG260 |
| B | HIS261 |
| B | ASN262 |
| B | PHE265 |
| B | GLU269 |
| B | TYR271 |
| B | GLU411 |
| B | HIS412 |
| B | ALA413 |
| B | ASN414 |
| B | PHE416 |
| B | GLU418 |
| B | GLY467 |
| B | ARG470 |
| B | HOH706 |
| B | MG1100 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PE B 494 |
| Chain | Residue |
| A | LEU179 |
| A | GLN182 |
| A | ARG186 |
| A | GLU294 |
| B | ASP189 |
| B | TYR193 |
| B | LEU194 |
| B | GLU195 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 1200 |
| Chain | Residue |
| C | GLU404 |
| C | GLU411 |
| C | ASN414 |
| C | XAH1201 |
| site_id | AC8 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE XAH C 1201 |
| Chain | Residue |
| C | MG1200 |
| C | GLY207 |
| C | ALA208 |
| C | GLU231 |
| C | ARG253 |
| C | ARG260 |
| C | HIS261 |
| C | ASN262 |
| C | PHE265 |
| C | MET267 |
| C | GLU269 |
| C | TYR271 |
| C | GLU411 |
| C | HIS412 |
| C | ALA413 |
| C | ASN414 |
| C | PHE416 |
| C | GLU418 |
| C | GLY465 |
| C | GLY467 |
| C | ARG470 |
| C | ILE481 |
| C | HOH780 |
| C | HOH788 |
| C | HOH925 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 1PE C 494 |
| Chain | Residue |
| C | LEU179 |
| C | GLN182 |
| C | ARG186 |
| C | GLU294 |
| D | ASP189 |
| D | SER190 |
| D | TYR193 |
| D | LEU194 |
| D | GLU195 |
| D | HOH930 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PE C 1202 |
| Chain | Residue |
| C | ARG186 |
| C | ASP189 |
| C | SER190 |
| C | TYR193 |
| C | LEU194 |
| C | GLU195 |
| D | GLN182 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 1300 |
| Chain | Residue |
| D | GLU404 |
| D | GLU411 |
| D | ASN414 |
| D | XAH1301 |
| site_id | BC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE XAH D 1301 |
| Chain | Residue |
| D | GLY207 |
| D | ALA208 |
| D | ALA229 |
| D | GLU231 |
| D | ARG253 |
| D | GLU255 |
| D | ARG260 |
| D | HIS261 |
| D | ASN262 |
| D | PHE265 |
| D | GLU269 |
| D | TYR271 |
| D | GLU411 |
| D | HIS412 |
| D | ASN414 |
| D | PHE416 |
| D | GLU418 |
| D | GLY467 |
| D | ARG470 |
| D | ILE481 |
| D | HOH870 |
| D | MG1300 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU404 | |
| A | GLU411 | |
| B | GLU404 | |
| B | GLU411 | |
| C | GLU404 | |
| C | GLU411 | |
| D | GLU404 | |
| D | GLU411 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1asy |
| Chain | Residue | Details |
| A | GLU269 | |
| A | ARG470 | |
| A | ARG253 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1asy |
| Chain | Residue | Details |
| B | GLU269 | |
| B | ARG470 | |
| B | ARG253 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1asy |
| Chain | Residue | Details |
| C | GLU269 | |
| C | ARG470 | |
| C | ARG253 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1asy |
| Chain | Residue | Details |
| D | GLU269 | |
| D | ARG470 | |
| D | ARG253 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1asy |
| Chain | Residue | Details |
| A | ARG253 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1asy |
| Chain | Residue | Details |
| B | ARG253 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1asy |
| Chain | Residue | Details |
| C | ARG253 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1asy |
| Chain | Residue | Details |
| D | ARG253 |
