3E9E
Structure of full-length H11A mutant form of TIGAR from Danio rerio
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004331 | molecular_function | fructose-2,6-bisphosphate 2-phosphatase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006914 | biological_process | autophagy |
| A | 0006915 | biological_process | apoptotic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0043456 | biological_process | regulation of pentose-phosphate shunt |
| A | 0045820 | biological_process | negative regulation of glycolytic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004331 | molecular_function | fructose-2,6-bisphosphate 2-phosphatase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0006914 | biological_process | autophagy |
| B | 0006915 | biological_process | apoptotic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0043456 | biological_process | regulation of pentose-phosphate shunt |
| B | 0045820 | biological_process | negative regulation of glycolytic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 266 |
| Chain | Residue |
| A | ARG10 |
| A | ARG61 |
| A | GLU89 |
| A | HIS183 |
| A | GLY184 |
| A | HOH304 |
| A | HOH359 |
| A | HOH393 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 B 266 |
| Chain | Residue |
| B | ASN17 |
| B | GLN23 |
| B | ARG61 |
| B | GLU89 |
| B | HIS183 |
| B | GLY184 |
| B | ASN217 |
| B | HOH353 |
| B | ARG10 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"PubMed","id":"19015259","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"19015259","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"19015259","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 2bif |
| Chain | Residue | Details |
| A | ARG61 | |
| A | ASN17 | |
| A | ARG10 | |
| A | HIS183 | |
| A | ALA11 | |
| A | GLU89 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 2bif |
| Chain | Residue | Details |
| B | ARG61 | |
| B | ASN17 | |
| B | ARG10 | |
| B | HIS183 | |
| B | ALA11 | |
| B | GLU89 |
