3E8E

Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001669	cellular_component	acrosomal vesicle
A	0001707	biological_process	mesoderm formation
A	0001843	biological_process	neural tube closure
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004691	molecular_function	cAMP-dependent protein kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005930	cellular_component	axoneme
A	0005952	cellular_component	cAMP-dependent protein kinase complex
A	0006397	biological_process	mRNA processing
A	0006468	biological_process	protein phosphorylation
A	0006611	biological_process	protein export from nucleus
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0019901	molecular_function	protein kinase binding
A	0019904	molecular_function	protein domain specific binding
A	0030007	biological_process	intracellular potassium ion homeostasis
A	0030145	molecular_function	manganese ion binding
A	0031594	cellular_component	neuromuscular junction
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032024	biological_process	positive regulation of insulin secretion
A	0034237	molecular_function	protein kinase A regulatory subunit binding
A	0034605	biological_process	cellular response to heat
A	0036126	cellular_component	sperm flagellum
A	0044853	cellular_component	plasma membrane raft
A	0045542	biological_process	positive regulation of cholesterol biosynthetic process
A	0045667	biological_process	regulation of osteoblast differentiation
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045879	biological_process	negative regulation of smoothened signaling pathway
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0048240	biological_process	sperm capacitation
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050766	biological_process	positive regulation of phagocytosis
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0051726	biological_process	regulation of cell cycle
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070417	biological_process	cellular response to cold
A	0070613	biological_process	regulation of protein processing
A	0071333	biological_process	cellular response to glucose stimulus
A	0071374	biological_process	cellular response to parathyroid hormone stimulus
A	0071377	biological_process	cellular response to glucagon stimulus
A	0097546	cellular_component	ciliary base
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
A	0106310	molecular_function	protein serine kinase activity
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
A	1990044	biological_process	protein localization to lipid droplet
A	2000810	biological_process	regulation of bicellular tight junction assembly
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001669	cellular_component	acrosomal vesicle
B	0001707	biological_process	mesoderm formation
B	0001843	biological_process	neural tube closure
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004691	molecular_function	cAMP-dependent protein kinase activity
B	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005930	cellular_component	axoneme
B	0005952	cellular_component	cAMP-dependent protein kinase complex
B	0006397	biological_process	mRNA processing
B	0006468	biological_process	protein phosphorylation
B	0006611	biological_process	protein export from nucleus
B	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
B	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016607	cellular_component	nuclear speck
B	0016740	molecular_function	transferase activity
B	0018105	biological_process	peptidyl-serine phosphorylation
B	0019901	molecular_function	protein kinase binding
B	0019904	molecular_function	protein domain specific binding
B	0030007	biological_process	intracellular potassium ion homeostasis
B	0030145	molecular_function	manganese ion binding
B	0031594	cellular_component	neuromuscular junction
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032024	biological_process	positive regulation of insulin secretion
B	0034237	molecular_function	protein kinase A regulatory subunit binding
B	0034605	biological_process	cellular response to heat
B	0036126	cellular_component	sperm flagellum
B	0044853	cellular_component	plasma membrane raft
B	0045542	biological_process	positive regulation of cholesterol biosynthetic process
B	0045667	biological_process	regulation of osteoblast differentiation
B	0045722	biological_process	positive regulation of gluconeogenesis
B	0045879	biological_process	negative regulation of smoothened signaling pathway
B	0046827	biological_process	positive regulation of protein export from nucleus
B	0048240	biological_process	sperm capacitation
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050766	biological_process	positive regulation of phagocytosis
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0051726	biological_process	regulation of cell cycle
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	0070417	biological_process	cellular response to cold
B	0070613	biological_process	regulation of protein processing
B	0071333	biological_process	cellular response to glucose stimulus
B	0071374	biological_process	cellular response to parathyroid hormone stimulus
B	0071377	biological_process	cellular response to glucagon stimulus
B	0097546	cellular_component	ciliary base
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
B	0106310	molecular_function	protein serine kinase activity
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
B	1990044	biological_process	protein localization to lipid droplet
B	2000810	biological_process	regulation of bicellular tight junction assembly
C	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
C	0006469	biological_process	negative regulation of protein kinase activity
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001669	cellular_component	acrosomal vesicle
E	0001707	biological_process	mesoderm formation
E	0001843	biological_process	neural tube closure
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004691	molecular_function	cAMP-dependent protein kinase activity
E	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005930	cellular_component	axoneme
E	0005952	cellular_component	cAMP-dependent protein kinase complex
E	0006397	biological_process	mRNA processing
E	0006468	biological_process	protein phosphorylation
E	0006611	biological_process	protein export from nucleus
E	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
E	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016607	cellular_component	nuclear speck
E	0016740	molecular_function	transferase activity
E	0018105	biological_process	peptidyl-serine phosphorylation
E	0019901	molecular_function	protein kinase binding
E	0019904	molecular_function	protein domain specific binding
E	0030007	biological_process	intracellular potassium ion homeostasis
E	0030145	molecular_function	manganese ion binding
E	0031594	cellular_component	neuromuscular junction
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032024	biological_process	positive regulation of insulin secretion
E	0034237	molecular_function	protein kinase A regulatory subunit binding
E	0034605	biological_process	cellular response to heat
E	0036126	cellular_component	sperm flagellum
E	0044853	cellular_component	plasma membrane raft
E	0045542	biological_process	positive regulation of cholesterol biosynthetic process
E	0045667	biological_process	regulation of osteoblast differentiation
E	0045722	biological_process	positive regulation of gluconeogenesis
E	0045879	biological_process	negative regulation of smoothened signaling pathway
E	0046827	biological_process	positive regulation of protein export from nucleus
E	0048240	biological_process	sperm capacitation
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050766	biological_process	positive regulation of phagocytosis
E	0050804	biological_process	modulation of chemical synaptic transmission
E	0051726	biological_process	regulation of cell cycle
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0070417	biological_process	cellular response to cold
E	0070613	biological_process	regulation of protein processing
E	0071333	biological_process	cellular response to glucose stimulus
E	0071374	biological_process	cellular response to parathyroid hormone stimulus
E	0071377	biological_process	cellular response to glucagon stimulus
E	0097546	cellular_component	ciliary base
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
E	0106310	molecular_function	protein serine kinase activity
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
E	1990044	biological_process	protein localization to lipid droplet
E	2000810	biological_process	regulation of bicellular tight junction assembly
F	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
F	0006469	biological_process	negative regulation of protein kinase activity
G	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
G	0006469	biological_process	negative regulation of protein kinase activity
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0001669	cellular_component	acrosomal vesicle
I	0001707	biological_process	mesoderm formation
I	0001843	biological_process	neural tube closure
I	0004672	molecular_function	protein kinase activity
I	0004674	molecular_function	protein serine/threonine kinase activity
I	0004691	molecular_function	cAMP-dependent protein kinase activity
I	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0005930	cellular_component	axoneme
I	0005952	cellular_component	cAMP-dependent protein kinase complex
I	0006397	biological_process	mRNA processing
I	0006468	biological_process	protein phosphorylation
I	0006611	biological_process	protein export from nucleus
I	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
I	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
I	0016020	cellular_component	membrane
I	0016301	molecular_function	kinase activity
I	0016607	cellular_component	nuclear speck
I	0016740	molecular_function	transferase activity
I	0018105	biological_process	peptidyl-serine phosphorylation
I	0019901	molecular_function	protein kinase binding
I	0019904	molecular_function	protein domain specific binding
I	0030007	biological_process	intracellular potassium ion homeostasis
I	0030145	molecular_function	manganese ion binding
I	0031594	cellular_component	neuromuscular junction
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0032024	biological_process	positive regulation of insulin secretion
I	0034237	molecular_function	protein kinase A regulatory subunit binding
I	0034605	biological_process	cellular response to heat
I	0036126	cellular_component	sperm flagellum
I	0044853	cellular_component	plasma membrane raft
I	0045542	biological_process	positive regulation of cholesterol biosynthetic process
I	0045667	biological_process	regulation of osteoblast differentiation
I	0045722	biological_process	positive regulation of gluconeogenesis
I	0045879	biological_process	negative regulation of smoothened signaling pathway
I	0046827	biological_process	positive regulation of protein export from nucleus
I	0048240	biological_process	sperm capacitation
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0050766	biological_process	positive regulation of phagocytosis
I	0050804	biological_process	modulation of chemical synaptic transmission
I	0051726	biological_process	regulation of cell cycle
I	0061136	biological_process	regulation of proteasomal protein catabolic process
I	0070417	biological_process	cellular response to cold
I	0070613	biological_process	regulation of protein processing
I	0071333	biological_process	cellular response to glucose stimulus
I	0071374	biological_process	cellular response to parathyroid hormone stimulus
I	0071377	biological_process	cellular response to glucagon stimulus
I	0097546	cellular_component	ciliary base
I	0098794	cellular_component	postsynapse
I	0098978	cellular_component	glutamatergic synapse
I	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
I	0106310	molecular_function	protein serine kinase activity
I	1904262	biological_process	negative regulation of TORC1 signaling
I	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
I	1990044	biological_process	protein localization to lipid droplet
I	2000810	biological_process	regulation of bicellular tight junction assembly
J	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
J	0006469	biological_process	negative regulation of protein kinase activity
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0001669	cellular_component	acrosomal vesicle
L	0001707	biological_process	mesoderm formation
L	0001843	biological_process	neural tube closure
L	0004672	molecular_function	protein kinase activity
L	0004674	molecular_function	protein serine/threonine kinase activity
L	0004691	molecular_function	cAMP-dependent protein kinase activity
L	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0005930	cellular_component	axoneme
L	0005952	cellular_component	cAMP-dependent protein kinase complex
L	0006397	biological_process	mRNA processing
L	0006468	biological_process	protein phosphorylation
L	0006611	biological_process	protein export from nucleus
L	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
L	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
L	0016020	cellular_component	membrane
L	0016301	molecular_function	kinase activity
L	0016607	cellular_component	nuclear speck
L	0016740	molecular_function	transferase activity
L	0018105	biological_process	peptidyl-serine phosphorylation
L	0019901	molecular_function	protein kinase binding
L	0019904	molecular_function	protein domain specific binding
L	0030007	biological_process	intracellular potassium ion homeostasis
L	0030145	molecular_function	manganese ion binding
L	0031594	cellular_component	neuromuscular junction
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032024	biological_process	positive regulation of insulin secretion
L	0034237	molecular_function	protein kinase A regulatory subunit binding
L	0034605	biological_process	cellular response to heat
L	0036126	cellular_component	sperm flagellum
L	0044853	cellular_component	plasma membrane raft
L	0045542	biological_process	positive regulation of cholesterol biosynthetic process
L	0045667	biological_process	regulation of osteoblast differentiation
L	0045722	biological_process	positive regulation of gluconeogenesis
L	0045879	biological_process	negative regulation of smoothened signaling pathway
L	0046827	biological_process	positive regulation of protein export from nucleus
L	0048240	biological_process	sperm capacitation
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0050766	biological_process	positive regulation of phagocytosis
L	0050804	biological_process	modulation of chemical synaptic transmission
L	0051726	biological_process	regulation of cell cycle
L	0061136	biological_process	regulation of proteasomal protein catabolic process
L	0070417	biological_process	cellular response to cold
L	0070613	biological_process	regulation of protein processing
L	0071333	biological_process	cellular response to glucose stimulus
L	0071374	biological_process	cellular response to parathyroid hormone stimulus
L	0071377	biological_process	cellular response to glucagon stimulus
L	0097546	cellular_component	ciliary base
L	0098794	cellular_component	postsynapse
L	0098978	cellular_component	glutamatergic synapse
L	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
L	0106310	molecular_function	protein serine kinase activity
L	1904262	biological_process	negative regulation of TORC1 signaling
L	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
L	1990044	biological_process	protein localization to lipid droplet
L	2000810	biological_process	regulation of bicellular tight junction assembly
N	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
N	0006469	biological_process	negative regulation of protein kinase activity
P	0000166	molecular_function	nucleotide binding
P	0000287	molecular_function	magnesium ion binding
P	0001669	cellular_component	acrosomal vesicle
P	0001707	biological_process	mesoderm formation
P	0001843	biological_process	neural tube closure
P	0004672	molecular_function	protein kinase activity
P	0004674	molecular_function	protein serine/threonine kinase activity
P	0004691	molecular_function	cAMP-dependent protein kinase activity
P	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005813	cellular_component	centrosome
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0005930	cellular_component	axoneme
P	0005952	cellular_component	cAMP-dependent protein kinase complex
P	0006397	biological_process	mRNA processing
P	0006468	biological_process	protein phosphorylation
P	0006611	biological_process	protein export from nucleus
P	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
P	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
P	0016020	cellular_component	membrane
P	0016301	molecular_function	kinase activity
P	0016607	cellular_component	nuclear speck
P	0016740	molecular_function	transferase activity
P	0018105	biological_process	peptidyl-serine phosphorylation
P	0019901	molecular_function	protein kinase binding
P	0019904	molecular_function	protein domain specific binding
P	0030007	biological_process	intracellular potassium ion homeostasis
P	0030145	molecular_function	manganese ion binding
P	0031594	cellular_component	neuromuscular junction
P	0031625	molecular_function	ubiquitin protein ligase binding
P	0032024	biological_process	positive regulation of insulin secretion
P	0034237	molecular_function	protein kinase A regulatory subunit binding
P	0034605	biological_process	cellular response to heat
P	0036126	cellular_component	sperm flagellum
P	0044853	cellular_component	plasma membrane raft
P	0045542	biological_process	positive regulation of cholesterol biosynthetic process
P	0045667	biological_process	regulation of osteoblast differentiation
P	0045722	biological_process	positive regulation of gluconeogenesis
P	0045879	biological_process	negative regulation of smoothened signaling pathway
P	0046827	biological_process	positive regulation of protein export from nucleus
P	0048240	biological_process	sperm capacitation
P	0048471	cellular_component	perinuclear region of cytoplasm
P	0050766	biological_process	positive regulation of phagocytosis
P	0050804	biological_process	modulation of chemical synaptic transmission
P	0051726	biological_process	regulation of cell cycle
P	0061136	biological_process	regulation of proteasomal protein catabolic process
P	0070417	biological_process	cellular response to cold
P	0070613	biological_process	regulation of protein processing
P	0071333	biological_process	cellular response to glucose stimulus
P	0071374	biological_process	cellular response to parathyroid hormone stimulus
P	0071377	biological_process	cellular response to glucagon stimulus
P	0097546	cellular_component	ciliary base
P	0098794	cellular_component	postsynapse
P	0098978	cellular_component	glutamatergic synapse
P	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
P	0106310	molecular_function	protein serine kinase activity
P	1904262	biological_process	negative regulation of TORC1 signaling
P	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
P	1990044	biological_process	protein localization to lipid droplet
P	2000810	biological_process	regulation of bicellular tight junction assembly
Q	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
Q	0006469	biological_process	negative regulation of protein kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE G98 A 351

Chain	Residue
A	LEU49
A	GLU91
A	LEU95
A	VAL104
A	MET120
A	GLU121
A	TYR122
A	VAL123
A	LEU173
A	THR183
A	ASP184
A	GLY50
A	PHE185
A	PHE327
A	THR51
A	PHE54
A	GLY55
A	ARG56
A	VAL57
A	ALA70
A	LYS72

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE G98 B 351

Chain	Residue
B	LEU49
B	GLY50
B	GLY55
B	ARG56
B	LYS72
B	GLU91
B	LEU95
B	VAL104
B	MET120
B	GLU121
B	VAL123
B	ASN171
B	LEU173
B	THR183
B	ASP184
B	PHE185
B	PHE327

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE G98 E 351

Chain	Residue
E	GLY55
E	ARG56
E	VAL57
E	LYS72
E	GLU91
E	LEU95
E	VAL104
E	MET120
E	GLU121
E	TYR122
E	VAL123
E	LEU173
E	THR183
E	ASP184
E	PHE185
E	PHE327

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE G98 I 351

Chain	Residue
I	LEU49
I	GLY55
I	LYS72
I	GLU91
I	LEU95
I	VAL104
I	MET120
I	GLU121
I	TYR122
I	VAL123
I	LEU173
I	THR183
I	ASP184
I	PHE185
I	PHE327

---

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE G98 L 351

Chain	Residue
L	LEU49
L	THR51
L	GLY55
L	ARG56
L	VAL57
L	LYS72
L	GLU91
L	LEU95
L	MET120
L	GLU121
L	TYR122
L	VAL123
L	LEU173
L	THR183
L	ASP184
L	PHE185
L	PHE327

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE G98 P 351

Chain	Residue
P	TYR122
P	VAL123
P	LEU173
P	THR183
P	ASP184
P	PHE185
P	PHE327
P	LEU49
P	GLY50
P	THR51
P	GLY55
P	ARG56
P	VAL57
P	ALA70
P	LYS72
P	GLU91
P	LEU95
P	VAL104
P	MET120
P	GLU121

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhmetgnh..........YAMK

Chain	Residue	Details
A	LEU49-LYS72

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI

Chain	Residue	Details
A	LEU162-ILE174

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	SITE: Important for inhibition => ECO:0000250

Chain	Residue	Details
G	ARG15
J	ARG15
J	ARG18
J	ARG19
N	ARG15
N	ARG18
N	ARG19
Q	ARG15
Q	ARG18
Q	ARG19
G	ARG18
G	ARG19
C	ARG15
C	ARG18
C	ARG19
F	ARG15
F	ARG18
F	ARG19

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	LEU49
L	LYS72
P	LEU49
P	LYS72
A	LYS72
B	LEU49
B	LYS72
E	LEU49
E	LYS72
I	LEU49
I	LYS72
L	LEU49

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	GLU121
L	LYS168
P	GLU121
P	LYS168
A	LYS168
B	GLU121
B	LYS168
E	GLU121
E	LYS168
I	GLU121
I	LYS168
L	GLU121

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Deamidated asparagine; partial => ECO:0000269|PubMed:10684253, ECO:0000269|PubMed:11152138, ECO:0000269|PubMed:9521123

Chain	Residue	Details
A	ASN2
B	ASN2
E	ASN2
I	ASN2
L	ASN2
P	ASN2

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P05132

Chain	Residue	Details
A	SEP10
B	SEP10
E	SEP10
I	SEP10
L	SEP10
P	SEP10

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P17612

Chain	Residue	Details
A	THR48
L	THR195
P	THR48
P	THR195
A	THR195
B	THR48
B	THR195
E	THR48
E	THR195
I	THR48
I	THR195
L	THR48

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P05132

Chain	Residue	Details
A	SER139
B	SER139
E	SER139
I	SER139
L	SER139
P	SER139

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:6262777

Chain	Residue	Details
A	TPO197
B	TPO197
E	TPO197
I	TPO197
L	TPO197
P	TPO197

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05132

Chain	Residue	Details
A	TYR330
B	TYR330
E	TYR330
I	TYR330
L	TYR330
P	TYR330

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:6262777

Chain	Residue	Details
A	SEP338
B	SEP338
E	SEP338
I	SEP338
L	SEP338
P	SEP338

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	LIPID: N-myristoyl glycine => ECO:0000269|PubMed:6262777

Chain	Residue	Details
A	GLY1
B	GLY1
E	GLY1
I	GLY1
L	GLY1
P	GLY1

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	GLU170
A	ASP166

---

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
I	ASP166
I	LYS168

---

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
L	ASP166
L	LYS168

---

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
P	ASP166
P	LYS168

---

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR201
A	ASP166
A	LYS168

---

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	THR201
B	ASP166
B	LYS168

---

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	THR201
E	ASP166
E	LYS168

---

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
I	THR201
I	ASP166
I	LYS168

---

site_id	CSA17
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
L	THR201
L	ASP166
L	LYS168

---

site_id	CSA18
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
P	THR201
P	ASP166
P	LYS168

---

site_id	CSA19
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP166
A	ASN171
A	LYS168

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	GLU170
B	ASP166

---

site_id	CSA20
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP166
B	ASN171
B	LYS168

---

site_id	CSA21
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP166
E	ASN171
E	LYS168

---

site_id	CSA22
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
I	ASP166
I	ASN171
I	LYS168

---

site_id	CSA23
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
L	ASP166
L	ASN171
L	LYS168

---

site_id	CSA24
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
P	ASP166
P	ASN171
P	LYS168

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	GLU170
E	ASP166

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
I	GLU170
I	ASP166

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
L	GLU170
L	ASP166

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
P	GLU170
P	ASP166

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP166
A	LYS168

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP166
B	LYS168

---

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP166
E	LYS168

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 757

Chain	Residue	Details
A	GLU170	activator, proton acceptor, proton donor
A	LEU172	electrostatic stabiliser, polar interaction
A	ASP175	metal ligand
A	ALA188	metal ligand
A	ILE209	electrostatic stabiliser, polar interaction

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 757

Chain

Residue

Details

---

site_id	MCSA3
Number of Residues	5
Details	M-CSA 757

Chain	Residue	Details
E	GLU170	activator, proton acceptor, proton donor
E	LEU172	electrostatic stabiliser, polar interaction
E	ASP175	metal ligand
E	ALA188	metal ligand
E	ILE209	electrostatic stabiliser, polar interaction

---

site_id	MCSA4
Number of Residues	5
Details	M-CSA 757

Chain

Residue

Details

---

site_id	MCSA5
Number of Residues	5
Details	M-CSA 757

Chain	Residue	Details
I	GLU170	activator, proton acceptor, proton donor
I	LEU172	electrostatic stabiliser, polar interaction
I	ASP175	metal ligand
I	ALA188	metal ligand
I	ILE209	electrostatic stabiliser, polar interaction

---

site_id	MCSA6
Number of Residues	5
Details	M-CSA 757

Chain

Residue

Details

---