3E7W

Crystal structure of DLTA: Implications for the reaction mechanism of non-ribosomal peptide synthetase (NRPS) adenylation domains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0016874	molecular_function	ligase activity
A	0047473	molecular_function	D-alanine [D-alanyl carrier protein] ligase activity
A	0070395	biological_process	lipoteichoic acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 512

Chain	Residue
A	THR13
A	TYR14
A	PRO15
A	GLN16
A	THR17
A	GLN485
A	ARG496

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AMP A 513

Chain	Residue
A	ASN291
A	THR292
A	TYR293
A	GLY294
A	THR296
A	ASP382
A	ARG396
A	LYS402
A	ARG407
A	HOH661
A	HOH767
A	HOH815
A	HOH831
A	GLY269
A	GLU270

---

Functional Information from PROSITE/UniProt

site_id	PS00455
Number of Residues	12
Details	AMP_BINDING Putative AMP-binding domain signature. IIYTSGSTGnPK

Chain	Residue	Details
A	ILE148-LYS159

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00593

Chain	Residue	Details
A	THR151
A	ASP196
A	VAL300
A	LYS491

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00593, ECO:0000269|PubMed:18784082, ECO:0007744|PDB:3E7W, ECO:0007744|PDB:3E7X

Chain	Residue	Details
A	ASN291
A	ASP382

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18784082, ECO:0007744|PDB:3E7W, ECO:0007744|PDB:3E7X

Chain	Residue	Details
A	ARG407

---