Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004517 | molecular_function | nitric-oxide synthase activity |
A | 0006809 | biological_process | nitric oxide biosynthetic process |
B | 0004517 | molecular_function | nitric-oxide synthase activity |
B | 0006809 | biological_process | nitric oxide biosynthetic process |
C | 0004517 | molecular_function | nitric-oxide synthase activity |
C | 0006809 | biological_process | nitric oxide biosynthetic process |
D | 0004517 | molecular_function | nitric-oxide synthase activity |
D | 0006809 | biological_process | nitric oxide biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A3001 |
Chain | Residue |
A | CYS110 |
A | CYS115 |
B | CYS110 |
B | CYS115 |
site_id | AC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE HEM A 901 |
Chain | Residue |
A | ASN370 |
A | TRP372 |
A | GLU377 |
A | TRP463 |
A | TYR489 |
A | TYR491 |
A | H4B902 |
A | AT2906 |
A | HOH4015 |
A | HOH4023 |
A | HOH4048 |
A | HOH4116 |
A | HOH4121 |
A | TRP194 |
A | ARG199 |
A | CYS200 |
A | SER242 |
A | PHE369 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE H4B A 902 |
Chain | Residue |
A | SER118 |
A | MET120 |
A | ARG381 |
A | ILE462 |
A | TRP463 |
A | HEM901 |
A | HOH4072 |
A | HOH4123 |
B | PHE476 |
B | HIS477 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE AT2 A 906 |
Chain | Residue |
A | GLN263 |
A | ARG266 |
A | TYR347 |
A | PRO350 |
A | PHE369 |
A | GLY371 |
A | TRP372 |
A | TYR373 |
A | GLU377 |
A | ASP382 |
A | ARG388 |
A | HEM901 |
site_id | AC5 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE HEM B1901 |
Chain | Residue |
B | TRP194 |
B | ARG199 |
B | CYS200 |
B | SER242 |
B | PHE369 |
B | ASN370 |
B | TRP372 |
B | GLU377 |
B | TRP463 |
B | TYR489 |
B | TYR491 |
B | H4B1902 |
B | AT21906 |
B | HOH5026 |
B | HOH5051 |
B | HOH5061 |
B | HOH5075 |
B | HOH5093 |
B | HOH5110 |
site_id | AC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE H4B B1902 |
Chain | Residue |
A | PHE476 |
A | HIS477 |
A | GLN478 |
B | SER118 |
B | MET120 |
B | ARG381 |
B | ILE462 |
B | TRP463 |
B | HEM1901 |
B | HOH5093 |
site_id | AC7 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE AT2 B1906 |
Chain | Residue |
B | GLN263 |
B | ARG266 |
B | TYR347 |
B | PRO350 |
B | GLY371 |
B | TRP372 |
B | TYR373 |
B | GLU377 |
B | ASP382 |
B | ARG388 |
B | HEM1901 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C3002 |
Chain | Residue |
C | CYS110 |
C | CYS115 |
D | CYS110 |
D | CYS115 |
site_id | AC9 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE HEM C2901 |
Chain | Residue |
C | H4B2902 |
C | AT22906 |
C | HOH6014 |
C | HOH6047 |
C | HOH6050 |
C | HOH6079 |
C | HOH6080 |
C | HOH6131 |
C | TRP194 |
C | ARG199 |
C | CYS200 |
C | SER242 |
C | PHE369 |
C | ASN370 |
C | TRP372 |
C | GLU377 |
C | TRP463 |
C | TYR489 |
C | TYR491 |
site_id | BC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE H4B C2902 |
Chain | Residue |
C | SER118 |
C | MET120 |
C | ARG381 |
C | ILE462 |
C | TRP463 |
C | HEM2901 |
C | HOH6033 |
C | HOH6087 |
C | HOH6131 |
D | PHE476 |
D | GLN478 |
site_id | BC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE AT2 C2906 |
Chain | Residue |
C | GLN263 |
C | ARG266 |
C | TYR347 |
C | PHE369 |
C | GLY371 |
C | TRP372 |
C | TYR373 |
C | GLU377 |
C | ASP382 |
C | ARG388 |
C | HEM2901 |
site_id | BC3 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE HEM D3901 |
Chain | Residue |
D | TRP194 |
D | ARG199 |
D | CYS200 |
D | SER242 |
D | PHE369 |
D | ASN370 |
D | TRP372 |
D | GLU377 |
D | TRP463 |
D | TYR489 |
D | TYR491 |
D | H4B3902 |
D | AT23906 |
D | HOH7024 |
D | HOH7044 |
D | HOH7048 |
D | HOH7088 |
D | HOH7091 |
site_id | BC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE H4B D3902 |
Chain | Residue |
C | PHE476 |
C | HIS477 |
C | GLU479 |
D | SER118 |
D | MET120 |
D | ARG381 |
D | ILE462 |
D | TRP463 |
D | HEM3901 |
D | HOH7035 |
D | HOH7092 |
D | HOH7106 |
site_id | BC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE AT2 D3906 |
Chain | Residue |
D | GLN263 |
D | ARG266 |
D | TYR347 |
D | PRO350 |
D | GLY371 |
D | TRP372 |
D | TYR373 |
D | GLU377 |
D | ASP382 |
D | ARG388 |
D | HEM3901 |
Functional Information from PROSITE/UniProt
site_id | PS60001 |
Number of Residues | 8 |
Details | NOS Nitric oxide synthase (NOS) signature. RCIGRIqW |
Chain | Residue | Details |
A | ARG199-TRP206 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | CYS110 | |
A | CYS115 | |
B | CYS110 | |
B | CYS115 | |
C | CYS110 | |
C | CYS115 | |
D | CYS110 | |
D | CYS115 | |
Chain | Residue | Details |
A | SER118 | |
B | TRP463 | |
B | PHE476 | |
B | TYR491 | |
C | SER118 | |
C | ARG381 | |
C | ILE462 | |
C | TRP463 | |
C | PHE476 | |
C | TYR491 | |
D | SER118 | |
A | ARG381 | |
D | ARG381 | |
D | ILE462 | |
D | TRP463 | |
D | PHE476 | |
D | TYR491 | |
A | ILE462 | |
A | TRP463 | |
A | PHE476 | |
A | TYR491 | |
B | SER118 | |
B | ARG381 | |
B | ILE462 | |
Chain | Residue | Details |
A | CYS200 | |
B | CYS200 | |
C | CYS200 | |
D | CYS200 | |
Chain | Residue | Details |
A | GLN263 | |
C | TRP372 | |
C | TYR373 | |
C | GLU377 | |
D | GLN263 | |
D | TRP372 | |
D | TYR373 | |
D | GLU377 | |
A | TRP372 | |
A | TYR373 | |
A | GLU377 | |
B | GLN263 | |
B | TRP372 | |
B | TYR373 | |
B | GLU377 | |
C | GLN263 | |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by PKA => ECO:0000255 |
Chain | Residue | Details |
A | SER234 | |
B | SER234 | |
C | SER234 | |
D | SER234 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 3nos |
Chain | Residue | Details |
A | TRP372 | |
A | CYS200 | |
A | GLU377 | |
A | ARG203 | |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 3nos |
Chain | Residue | Details |
B | TRP372 | |
B | CYS200 | |
B | GLU377 | |
B | ARG203 | |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 3nos |
Chain | Residue | Details |
C | TRP372 | |
C | CYS200 | |
C | GLU377 | |
C | ARG203 | |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 3nos |
Chain | Residue | Details |
D | TRP372 | |
D | CYS200 | |
D | GLU377 | |
D | ARG203 | |