3E7G
Structure of human INOSOX with inhibitor AR-C95791
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004517 | molecular_function | nitric-oxide synthase activity |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0004517 | molecular_function | nitric-oxide synthase activity |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
| C | 0004517 | molecular_function | nitric-oxide synthase activity |
| C | 0006809 | biological_process | nitric oxide biosynthetic process |
| D | 0004517 | molecular_function | nitric-oxide synthase activity |
| D | 0006809 | biological_process | nitric oxide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 3001 |
| Chain | Residue |
| A | CYS110 |
| A | CYS115 |
| B | CYS110 |
| B | CYS115 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE HEM A 901 |
| Chain | Residue |
| A | ASN370 |
| A | TRP372 |
| A | GLU377 |
| A | TRP463 |
| A | TYR489 |
| A | TYR491 |
| A | H4B902 |
| A | AT2906 |
| A | HOH4015 |
| A | HOH4023 |
| A | HOH4048 |
| A | HOH4116 |
| A | HOH4121 |
| A | TRP194 |
| A | ARG199 |
| A | CYS200 |
| A | SER242 |
| A | PHE369 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE H4B A 902 |
| Chain | Residue |
| A | SER118 |
| A | MET120 |
| A | ARG381 |
| A | ILE462 |
| A | TRP463 |
| A | HEM901 |
| A | HOH4072 |
| A | HOH4123 |
| B | PHE476 |
| B | HIS477 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE AT2 A 906 |
| Chain | Residue |
| A | GLN263 |
| A | ARG266 |
| A | TYR347 |
| A | PRO350 |
| A | PHE369 |
| A | GLY371 |
| A | TRP372 |
| A | TYR373 |
| A | GLU377 |
| A | ASP382 |
| A | ARG388 |
| A | HEM901 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEM B 1901 |
| Chain | Residue |
| B | TRP194 |
| B | ARG199 |
| B | CYS200 |
| B | SER242 |
| B | PHE369 |
| B | ASN370 |
| B | TRP372 |
| B | GLU377 |
| B | TRP463 |
| B | TYR489 |
| B | TYR491 |
| B | H4B1902 |
| B | AT21906 |
| B | HOH5026 |
| B | HOH5051 |
| B | HOH5061 |
| B | HOH5075 |
| B | HOH5093 |
| B | HOH5110 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE H4B B 1902 |
| Chain | Residue |
| A | PHE476 |
| A | HIS477 |
| A | GLN478 |
| B | SER118 |
| B | MET120 |
| B | ARG381 |
| B | ILE462 |
| B | TRP463 |
| B | HEM1901 |
| B | HOH5093 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE AT2 B 1906 |
| Chain | Residue |
| B | GLN263 |
| B | ARG266 |
| B | TYR347 |
| B | PRO350 |
| B | GLY371 |
| B | TRP372 |
| B | TYR373 |
| B | GLU377 |
| B | ASP382 |
| B | ARG388 |
| B | HEM1901 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 3002 |
| Chain | Residue |
| C | CYS110 |
| C | CYS115 |
| D | CYS110 |
| D | CYS115 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEM C 2901 |
| Chain | Residue |
| C | H4B2902 |
| C | AT22906 |
| C | HOH6014 |
| C | HOH6047 |
| C | HOH6050 |
| C | HOH6079 |
| C | HOH6080 |
| C | HOH6131 |
| C | TRP194 |
| C | ARG199 |
| C | CYS200 |
| C | SER242 |
| C | PHE369 |
| C | ASN370 |
| C | TRP372 |
| C | GLU377 |
| C | TRP463 |
| C | TYR489 |
| C | TYR491 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE H4B C 2902 |
| Chain | Residue |
| C | SER118 |
| C | MET120 |
| C | ARG381 |
| C | ILE462 |
| C | TRP463 |
| C | HEM2901 |
| C | HOH6033 |
| C | HOH6087 |
| C | HOH6131 |
| D | PHE476 |
| D | GLN478 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE AT2 C 2906 |
| Chain | Residue |
| C | GLN263 |
| C | ARG266 |
| C | TYR347 |
| C | PHE369 |
| C | GLY371 |
| C | TRP372 |
| C | TYR373 |
| C | GLU377 |
| C | ASP382 |
| C | ARG388 |
| C | HEM2901 |
| site_id | BC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE HEM D 3901 |
| Chain | Residue |
| D | TRP194 |
| D | ARG199 |
| D | CYS200 |
| D | SER242 |
| D | PHE369 |
| D | ASN370 |
| D | TRP372 |
| D | GLU377 |
| D | TRP463 |
| D | TYR489 |
| D | TYR491 |
| D | H4B3902 |
| D | AT23906 |
| D | HOH7024 |
| D | HOH7044 |
| D | HOH7048 |
| D | HOH7088 |
| D | HOH7091 |
| site_id | BC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE H4B D 3902 |
| Chain | Residue |
| C | PHE476 |
| C | HIS477 |
| C | GLU479 |
| D | SER118 |
| D | MET120 |
| D | ARG381 |
| D | ILE462 |
| D | TRP463 |
| D | HEM3901 |
| D | HOH7035 |
| D | HOH7092 |
| D | HOH7106 |
| site_id | BC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE AT2 D 3906 |
| Chain | Residue |
| D | GLN263 |
| D | ARG266 |
| D | TYR347 |
| D | PRO350 |
| D | GLY371 |
| D | TRP372 |
| D | TYR373 |
| D | GLU377 |
| D | ASP382 |
| D | ARG388 |
| D | HEM3901 |
Functional Information from PROSITE/UniProt
| site_id | PS60001 |
| Number of Residues | 8 |
| Details | NOS Nitric oxide synthase (NOS) signature. RCIGRIqW |
| Chain | Residue | Details |
| A | ARG199-TRP206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10074942","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10409685","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NOS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10074942","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10409685","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NOS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"10074942","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10409685","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NOS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| A | TRP372 | |
| A | CYS200 | |
| A | GLU377 | |
| A | ARG203 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| B | TRP372 | |
| B | CYS200 | |
| B | GLU377 | |
| B | ARG203 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| C | TRP372 | |
| C | CYS200 | |
| C | GLU377 | |
| C | ARG203 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| D | TRP372 | |
| D | CYS200 | |
| D | GLU377 | |
| D | ARG203 |
