Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3E7G

Structure of human INOSOX with inhibitor AR-C95791

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004517	molecular_function	nitric-oxide synthase activity
A	0006809	biological_process	nitric oxide biosynthetic process
B	0004517	molecular_function	nitric-oxide synthase activity
B	0006809	biological_process	nitric oxide biosynthetic process
C	0004517	molecular_function	nitric-oxide synthase activity
C	0006809	biological_process	nitric oxide biosynthetic process
D	0004517	molecular_function	nitric-oxide synthase activity
D	0006809	biological_process	nitric oxide biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A3001

Chain	Residue
A	CYS110
A	CYS115
B	CYS110
B	CYS115

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM A 901

Chain	Residue
A	ASN370
A	TRP372
A	GLU377
A	TRP463
A	TYR489
A	TYR491
A	H4B902
A	AT2906
A	HOH4015
A	HOH4023
A	HOH4048
A	HOH4116
A	HOH4121
A	TRP194
A	ARG199
A	CYS200
A	SER242
A	PHE369

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE H4B A 902

Chain	Residue
A	SER118
A	MET120
A	ARG381
A	ILE462
A	TRP463
A	HEM901
A	HOH4072
A	HOH4123
B	PHE476
B	HIS477

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AT2 A 906

Chain	Residue
A	GLN263
A	ARG266
A	TYR347
A	PRO350
A	PHE369
A	GLY371
A	TRP372
A	TYR373
A	GLU377
A	ASP382
A	ARG388
A	HEM901

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM B1901

Chain	Residue
B	TRP194
B	ARG199
B	CYS200
B	SER242
B	PHE369
B	ASN370
B	TRP372
B	GLU377
B	TRP463
B	TYR489
B	TYR491
B	H4B1902
B	AT21906
B	HOH5026
B	HOH5051
B	HOH5061
B	HOH5075
B	HOH5093
B	HOH5110

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE H4B B1902

Chain	Residue
A	PHE476
A	HIS477
A	GLN478
B	SER118
B	MET120
B	ARG381
B	ILE462
B	TRP463
B	HEM1901
B	HOH5093

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AT2 B1906

Chain	Residue
B	GLN263
B	ARG266
B	TYR347
B	PRO350
B	GLY371
B	TRP372
B	TYR373
B	GLU377
B	ASP382
B	ARG388
B	HEM1901

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C3002

Chain	Residue
C	CYS110
C	CYS115
D	CYS110
D	CYS115

site_id	AC9
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM C2901

Chain	Residue
C	H4B2902
C	AT22906
C	HOH6014
C	HOH6047
C	HOH6050
C	HOH6079
C	HOH6080
C	HOH6131
C	TRP194
C	ARG199
C	CYS200
C	SER242
C	PHE369
C	ASN370
C	TRP372
C	GLU377
C	TRP463
C	TYR489
C	TYR491

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE H4B C2902

Chain	Residue
C	SER118
C	MET120
C	ARG381
C	ILE462
C	TRP463
C	HEM2901
C	HOH6033
C	HOH6087
C	HOH6131
D	PHE476
D	GLN478

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AT2 C2906

Chain	Residue
C	GLN263
C	ARG266
C	TYR347
C	PHE369
C	GLY371
C	TRP372
C	TYR373
C	GLU377
C	ASP382
C	ARG388
C	HEM2901

site_id	BC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM D3901

Chain	Residue
D	TRP194
D	ARG199
D	CYS200
D	SER242
D	PHE369
D	ASN370
D	TRP372
D	GLU377
D	TRP463
D	TYR489
D	TYR491
D	H4B3902
D	AT23906
D	HOH7024
D	HOH7044
D	HOH7048
D	HOH7088
D	HOH7091

site_id	BC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE H4B D3902

Chain	Residue
C	PHE476
C	HIS477
C	GLU479
D	SER118
D	MET120
D	ARG381
D	ILE462
D	TRP463
D	HEM3901
D	HOH7035
D	HOH7092
D	HOH7106

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AT2 D3906

Chain	Residue
D	GLN263
D	ARG266
D	TYR347
D	PRO350
D	GLY371
D	TRP372
D	TYR373
D	GLU377
D	ASP382
D	ARG388
D	HEM3901

Functional Information from PROSITE/UniProt

site_id	PS60001
Number of Residues	8
Details	NOS Nitric oxide synthase (NOS) signature. RCIGRIqW

Chain	Residue	Details
A	ARG199-TRP206

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:10074942, ECO:0000269\|PubMed:10409685, ECO:0007744\|PDB:1NSI, ECO:0007744\|PDB:4NOS

Chain	Residue	Details
A	CYS110
A	CYS115
B	CYS110
B	CYS115
C	CYS110
C	CYS115
D	CYS110
D	CYS115

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:10074942, ECO:0000269\|PubMed:10409685, ECO:0007744\|PDB:1NSI, ECO:0007744\|PDB:2NSI, ECO:0007744\|PDB:4NOS

Chain	Residue	Details
A	SER118
B	TRP463
B	PHE476
B	TYR491
C	SER118
C	ARG381
C	ILE462
C	TRP463
C	PHE476
C	TYR491
D	SER118
A	ARG381
D	ARG381
D	ILE462
D	TRP463
D	PHE476
D	TYR491
A	ILE462
A	TRP463
A	PHE476
A	TYR491
B	SER118
B	ARG381
B	ILE462

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:10074942, ECO:0000269\|PubMed:10409685, ECO:0007744\|PDB:1NSI, ECO:0007744\|PDB:2NSI, ECO:0007744\|PDB:4NOS

Chain	Residue	Details
A	CYS200
B	CYS200
C	CYS200
D	CYS200

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P29474

Chain	Residue	Details
A	GLN263
C	TRP372
C	TYR373
C	GLU377
D	GLN263
D	TRP372
D	TYR373
D	GLU377
A	TRP372
A	TYR373
A	GLU377
B	GLN263
B	TRP372
B	TYR373
B	GLU377
C	GLN263

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000255

Chain	Residue	Details
A	SER234
B	SER234
C	SER234
D	SER234

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 3nos

Chain	Residue	Details
A	TRP372
A	CYS200
A	GLU377
A	ARG203

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 3nos

Chain	Residue	Details
B	TRP372
B	CYS200
B	GLU377
B	ARG203

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 3nos

Chain	Residue	Details
C	TRP372
C	CYS200
C	GLU377
C	ARG203

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 3nos

Chain	Residue	Details
D	TRP372
D	CYS200
D	GLU377
D	ARG203

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)