3E4W
Crystal structure of a 33kDa catalase-related protein from Mycobacterium avium subsp. paratuberculosis. P2(1)2(1)2(1) crystal form.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004096 | molecular_function | catalase activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0020037 | molecular_function | heme binding |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0042743 | biological_process | hydrogen peroxide metabolic process |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 2000377 | biological_process | regulation of reactive oxygen species metabolic process |
| B | 0004096 | molecular_function | catalase activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0020037 | molecular_function | heme binding |
| B | 0042542 | biological_process | response to hydrogen peroxide |
| B | 0042743 | biological_process | hydrogen peroxide metabolic process |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 2000377 | biological_process | regulation of reactive oxygen species metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE HEM A 501 |
| Chain | Residue |
| A | ARG25 |
| A | PHE113 |
| A | GLY164 |
| A | PHE270 |
| A | ARG290 |
| A | TYR294 |
| A | SER297 |
| A | ARG301 |
| A | HOH1256 |
| A | HOH1269 |
| A | ALA26 |
| A | LEU27 |
| A | HIS28 |
| A | ARG63 |
| A | SER98 |
| A | ALA99 |
| A | GLN100 |
| A | LEU105 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE HEM B 502 |
| Chain | Residue |
| B | ARG25 |
| B | ALA26 |
| B | LEU27 |
| B | HIS28 |
| B | ARG63 |
| B | SER98 |
| B | ALA99 |
| B | GLN100 |
| B | PHE113 |
| B | HIS163 |
| B | GLY164 |
| B | PHE270 |
| B | ARG290 |
| B | TYR294 |
| B | SER297 |
| B | ARG301 |
| B | HOH1312 |
| B | HOH1457 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HEZ A 1100 |
| Chain | Residue |
| A | HIS28 |
| A | GLN100 |
| A | ALA102 |
| A | LEU104 |
| A | LEU105 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE HEZ A 1110 |
| Chain | Residue |
| A | ARG103 |
| A | HIS183 |
| A | ARG224 |
| A | ILE246 |
| B | THR187 |
| B | ALA189 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HEZ B 1120 |
| Chain | Residue |
| A | THR187 |
| A | ALA189 |
| B | ARG103 |
| B | HIS183 |
| B | ARG224 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE HEZ A 1130 |
| Chain | Residue |
| A | ALA102 |
| A | LEU104 |
| A | LEU105 |
| A | LEU140 |
| A | LEU146 |
| A | SER238 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HEZ B 1140 |
| Chain | Residue |
| B | HIS28 |
| B | GLN100 |
| B | ALA102 |
| B | LEU105 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HEZ B 1150 |
| Chain | Residue |
| B | LEU104 |
| B | LEU105 |
| B | ARG139 |
| B | LEU147 |
| B | SER238 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1200 |
| Chain | Residue |
| A | SER107 |
| A | SER108 |
| A | THR109 |
| A | HIS137 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1210 |
| Chain | Residue |
| B | SER107 |
| B | SER108 |
| B | THR109 |
| B | GLY112 |
| B | HIS137 |
| B | HOH1417 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1220 |
| Chain | Residue |
| A | HIS137 |
| A | PRO138 |
| A | ARG139 |
| A | LEU140 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1230 |
| Chain | Residue |
| B | HIS137 |
| B | PRO138 |
| B | ARG139 |
| B | HOH1417 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1240 |
| Chain | Residue |
| A | HIS263 |
| A | GLY264 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1300 |
| Chain | Residue |
| A | PRO186 |
| A | GLU190 |
| A | ARG224 |
| B | GLU161 |
| B | PRO186 |
| B | GLU190 |
| B | ARG224 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P04040 |
| Chain | Residue | Details |
| A | HIS28 | |
| B | HIS28 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TYR294 | |
| B | TYR294 |
