3E3T
Structure of porcine pancreatic elastase with the magic triangle I3C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0006954 | biological_process | inflammatory response |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 241 |
| Chain | Residue |
| A | GLY118 |
| A | ARG136 |
| A | ARG225 |
| A | SER227 |
| A | ALA228 |
| A | HOH1042 |
| A | HOH1229 |
| A | HOH1280 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 242 |
| Chain | Residue |
| A | GLN185 |
| A | GLY186 |
| A | SER188 |
| A | HOH1064 |
| A | HOH1156 |
| A | HOH1207 |
| A | HIS45 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 243 |
| Chain | Residue |
| A | GLU59 |
| A | ASN61 |
| A | GLN64 |
| A | ASN66 |
| A | GLU69 |
| A | HOH1057 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 244 |
| Chain | Residue |
| A | THR135 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE I3C A 245 |
| Chain | Residue |
| A | TYR20 |
| A | ARG49 |
| A | LEU51 |
| A | SER160 |
| A | SER161 |
| A | GLY165 |
| A | SER166 |
| A | HOH1257 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE I3C A 246 |
| Chain | Residue |
| A | THR135 |
| A | GLN140 |
| A | LEU141 |
| A | GLN143 |
| A | ASN170 |
| A | HOH1081 |
| A | HOH1094 |
| A | HOH1225 |
| A | HOH1226 |
| A | HOH1235 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE I3C A 247 |
| Chain | Residue |
| A | GLN37 |
| A | SER102 |
| A | TYR163 |
| A | GLY177 |
| A | THR217 |
| A | ARG218 |
| A | HOH1115 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE I3C A 248 |
| Chain | Residue |
| A | ARG116 |
| A | ALA117 |
| A | ILE230 |
| A | SER231 |
| A | ASN234 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 237 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"4578945","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"5415110","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"5415110","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7656008","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ELA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ELB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ELC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | HIS45 | |
| A | ASP93 | |
| A | SER188 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY189 | |
| A | HIS45 | |
| A | ASP93 | |
| A | SER188 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY186 | |
| A | HIS45 | |
| A | ASP93 | |
| A | SER188 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | HIS45 | |
| A | ASP93 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY186 | |
| A | SER188 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY189 | |
| A | SER188 |
| site_id | CSA7 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER207 | |
| A | GLY186 | |
| A | HIS45 | |
| A | ASP93 | |
| A | SER188 |
