3E3T

Structure of porcine pancreatic elastase with the magic triangle I3C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 241

Chain	Residue
A	GLY118
A	ARG136
A	ARG225
A	SER227
A	ALA228
A	HOH1042
A	HOH1229
A	HOH1280

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 242

Chain	Residue
A	GLN185
A	GLY186
A	SER188
A	HOH1064
A	HOH1156
A	HOH1207
A	HIS45

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 243

Chain	Residue
A	GLU59
A	ASN61
A	GLN64
A	ASN66
A	GLU69
A	HOH1057

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 244

Chain	Residue
A	THR135

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE I3C A 245

Chain	Residue
A	TYR20
A	ARG49
A	LEU51
A	SER160
A	SER161
A	GLY165
A	SER166
A	HOH1257

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE I3C A 246

Chain	Residue
A	THR135
A	GLN140
A	LEU141
A	GLN143
A	ASN170
A	HOH1081
A	HOH1094
A	HOH1225
A	HOH1226
A	HOH1235

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE I3C A 247

Chain	Residue
A	GLN37
A	SER102
A	TYR163
A	GLY177
A	THR217
A	ARG218
A	HOH1115

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE I3C A 248

Chain	Residue
A	ARG116
A	ALA117
A	ILE230
A	SER231
A	ASN234

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MTAAHC

Chain	Residue	Details
A	MET41-CYS46

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. SGcqGDSGGPLH

Chain	Residue	Details
A	SER182-HIS193

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:4578945, ECO:0000269|PubMed:5415110

Chain	Residue	Details
A	HIS45

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:5415110

Chain	Residue	Details
A	ASP93
A	SER188

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC

Chain	Residue	Details
A	GLU59
A	ASN61
A	GLN64
A	GLU69

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	HIS45
A	ASP93
A	SER188

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	GLY189
A	HIS45
A	ASP93
A	SER188

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	GLY186
A	HIS45
A	ASP93
A	SER188

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	HIS45
A	ASP93

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	GLY186
A	SER188

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	GLY189
A	SER188

---

site_id	CSA7
Number of Residues	5
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER207
A	GLY186
A	HIS45
A	ASP93
A	SER188

---