3E3I
H. influenzae beta-carbonic anhydrase, variant G41A with 100 mM bicarbonate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004089 | molecular_function | carbonate dehydratase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0015976 | biological_process | carbon utilization |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004089 | molecular_function | carbonate dehydratase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0015976 | biological_process | carbon utilization |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004089 | molecular_function | carbonate dehydratase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0015976 | biological_process | carbon utilization |
| C | 0016829 | molecular_function | lyase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004089 | molecular_function | carbonate dehydratase activity |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0015976 | biological_process | carbon utilization |
| D | 0016829 | molecular_function | lyase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004089 | molecular_function | carbonate dehydratase activity |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0015976 | biological_process | carbon utilization |
| E | 0016829 | molecular_function | lyase activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004089 | molecular_function | carbonate dehydratase activity |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0015976 | biological_process | carbon utilization |
| F | 0016829 | molecular_function | lyase activity |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004089 | molecular_function | carbonate dehydratase activity |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0015976 | biological_process | carbon utilization |
| G | 0016829 | molecular_function | lyase activity |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004089 | molecular_function | carbonate dehydratase activity |
| H | 0008270 | molecular_function | zinc ion binding |
| H | 0015976 | biological_process | carbon utilization |
| H | 0016829 | molecular_function | lyase activity |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0004089 | molecular_function | carbonate dehydratase activity |
| I | 0008270 | molecular_function | zinc ion binding |
| I | 0015976 | biological_process | carbon utilization |
| I | 0016829 | molecular_function | lyase activity |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0004089 | molecular_function | carbonate dehydratase activity |
| J | 0008270 | molecular_function | zinc ion binding |
| J | 0015976 | biological_process | carbon utilization |
| J | 0016829 | molecular_function | lyase activity |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0004089 | molecular_function | carbonate dehydratase activity |
| K | 0008270 | molecular_function | zinc ion binding |
| K | 0015976 | biological_process | carbon utilization |
| K | 0016829 | molecular_function | lyase activity |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0004089 | molecular_function | carbonate dehydratase activity |
| L | 0008270 | molecular_function | zinc ion binding |
| L | 0015976 | biological_process | carbon utilization |
| L | 0016829 | molecular_function | lyase activity |
| L | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 230 |
| Chain | Residue |
| A | CYS42 |
| A | ASP44 |
| A | HIS98 |
| A | CYS101 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 231 |
| Chain | Residue |
| A | VAL183 |
| A | HOH278 |
| A | SER45 |
| A | ARG46 |
| A | VAL47 |
| A | HIS98 |
| A | TYR181 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 230 |
| Chain | Residue |
| B | CYS42 |
| B | ASP44 |
| B | HIS98 |
| B | CYS101 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 231 |
| Chain | Residue |
| A | LEU121 |
| A | ARG124 |
| B | ARG160 |
| B | ARG198 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 232 |
| Chain | Residue |
| A | ARG160 |
| A | ARG198 |
| B | LEU121 |
| B | ARG124 |
| B | PHE128 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE BCT B 233 |
| Chain | Residue |
| B | TRP39 |
| B | ALA41 |
| B | VAL47 |
| B | PRO48 |
| B | ALA49 |
| B | LEU52 |
| B | ARG64 |
| B | TYR181 |
| B | HOH248 |
| B | HOH260 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 230 |
| Chain | Residue |
| C | CYS42 |
| C | ASP44 |
| C | HIS98 |
| C | CYS101 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 231 |
| Chain | Residue |
| C | LEU121 |
| C | ARG124 |
| C | HOH270 |
| D | ARG160 |
| D | ARG198 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BCT C 232 |
| Chain | Residue |
| A | PRO48 |
| A | ARG64 |
| A | HOH238 |
| C | PRO48 |
| C | ALA49 |
| C | GLU50 |
| C | ARG64 |
| C | HOH268 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 230 |
| Chain | Residue |
| D | CYS42 |
| D | ASP44 |
| D | HIS98 |
| D | CYS101 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 231 |
| Chain | Residue |
| C | ARG160 |
| C | LYS165 |
| C | ARG198 |
| D | LEU121 |
| D | ARG124 |
| D | PHE128 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BCT D 232 |
| Chain | Residue |
| D | TRP39 |
| D | ALA41 |
| D | VAL47 |
| D | PRO48 |
| D | ALA49 |
| D | LEU52 |
| D | ARG64 |
| D | TYR181 |
| D | HOH276 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 230 |
| Chain | Residue |
| E | CYS42 |
| E | ASP44 |
| E | HIS98 |
| E | CYS101 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 E 231 |
| Chain | Residue |
| E | LEU121 |
| E | ARG124 |
| E | PHE128 |
| E | HOH260 |
| F | ARG160 |
| F | ARG198 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 E 232 |
| Chain | Residue |
| E | ARG160 |
| E | LYS165 |
| E | ARG198 |
| E | HOH277 |
| F | LEU121 |
| F | ARG124 |
| site_id | BC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BCT E 233 |
| Chain | Residue |
| E | TRP39 |
| E | ALA41 |
| E | VAL47 |
| E | PRO48 |
| E | ALA49 |
| E | LEU52 |
| E | ARG64 |
| E | TYR181 |
| E | HOH253 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 230 |
| Chain | Residue |
| F | CYS42 |
| F | ASP44 |
| F | HIS98 |
| F | CYS101 |
| site_id | BC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BCT F 231 |
| Chain | Residue |
| F | TRP39 |
| F | ALA41 |
| F | VAL47 |
| F | PRO48 |
| F | ALA49 |
| F | LEU52 |
| F | ARG64 |
| F | TYR181 |
| F | HOH260 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN G 230 |
| Chain | Residue |
| G | CYS42 |
| G | ASP44 |
| G | HIS98 |
| G | CYS101 |
| site_id | CC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BCT G 231 |
| Chain | Residue |
| G | TRP39 |
| G | ALA41 |
| G | VAL47 |
| G | PRO48 |
| G | ALA49 |
| G | ARG64 |
| G | TYR181 |
| G | HOH235 |
| G | HOH244 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN H 230 |
| Chain | Residue |
| H | CYS42 |
| H | ASP44 |
| H | HIS98 |
| H | CYS101 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 H 231 |
| Chain | Residue |
| G | LEU121 |
| G | ARG124 |
| H | ARG160 |
| H | LYS165 |
| H | ARG198 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 H 232 |
| Chain | Residue |
| G | ARG160 |
| G | LYS165 |
| G | ARG198 |
| H | LEU121 |
| H | ARG124 |
| H | HOH283 |
| site_id | CC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BCT H 233 |
| Chain | Residue |
| H | TRP39 |
| H | ALA41 |
| H | VAL47 |
| H | PRO48 |
| H | ALA49 |
| H | LEU52 |
| H | ARG64 |
| H | TYR181 |
| H | HOH250 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN I 230 |
| Chain | Residue |
| I | CYS42 |
| I | ASP44 |
| I | HIS98 |
| I | CYS101 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 I 231 |
| Chain | Residue |
| I | ARG160 |
| I | ARG198 |
| I | HOH270 |
| I | HOH275 |
| J | ARG124 |
| site_id | CC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BCT I 232 |
| Chain | Residue |
| I | TRP39 |
| I | ALA41 |
| I | VAL47 |
| I | ALA49 |
| I | ARG64 |
| I | TYR181 |
| I | HOH240 |
| I | HOH249 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN J 230 |
| Chain | Residue |
| J | CYS42 |
| J | ASP44 |
| J | HIS98 |
| J | CYS101 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 J 231 |
| Chain | Residue |
| I | LEU121 |
| I | ARG124 |
| J | ARG160 |
| J | LYS165 |
| J | ARG198 |
| site_id | DC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BCT J 232 |
| Chain | Residue |
| J | TRP39 |
| J | ALA41 |
| J | VAL47 |
| J | PRO48 |
| J | ALA49 |
| J | LEU52 |
| J | ARG64 |
| J | TYR181 |
| J | HOH256 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN K 230 |
| Chain | Residue |
| K | CYS42 |
| K | ASP44 |
| K | HIS98 |
| K | CYS101 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 K 231 |
| Chain | Residue |
| K | LEU121 |
| K | ARG124 |
| L | ARG160 |
| L | ARG198 |
| site_id | DC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BCT K 232 |
| Chain | Residue |
| K | TRP39 |
| K | ALA41 |
| K | VAL47 |
| K | ALA49 |
| K | ARG64 |
| K | TYR181 |
| K | HOH236 |
| K | HOH247 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN L 230 |
| Chain | Residue |
| L | CYS42 |
| L | ASP44 |
| L | HIS98 |
| L | CYS101 |
| site_id | DC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 L 231 |
| Chain | Residue |
| K | ARG160 |
| K | LYS165 |
| K | ARG198 |
| L | LEU121 |
| L | ARG124 |
| L | HOH258 |
| site_id | DC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BCT L 232 |
| Chain | Residue |
| L | TRP39 |
| L | ALA41 |
| L | VAL47 |
| L | PRO48 |
| L | ALA49 |
| L | ARG64 |
| L | TYR181 |
| L | HOH237 |
| L | HOH245 |
Functional Information from PROSITE/UniProt
| site_id | PS00704 |
| Number of Residues | 8 |
| Details | PROK_CO2_ANHYDRASE_1 Prokaryotic-type carbonic anhydrases signature 1. CSDSRVpA |
| Chain | Residue | Details |
| A | CYS42-ALA49 |
| site_id | PS00705 |
| Number of Residues | 21 |
| Details | PROK_CO2_ANHYDRASE_2 Prokaryotic-type carbonic anhydrases signature 2. QYAVdvLkiehIIIcGHtnCG |
| Chain | Residue | Details |
| A | GLN82-GLY102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16584170","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A8D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| A | ASP44 | |
| A | ARG46 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| J | ASP44 | |
| J | ARG46 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| K | ASP44 | |
| K | ARG46 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| L | ASP44 | |
| L | ARG46 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| B | ASP44 | |
| B | ARG46 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| C | ASP44 | |
| C | ARG46 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| D | ASP44 | |
| D | ARG46 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| E | ASP44 | |
| E | ARG46 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| F | ASP44 | |
| F | ARG46 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| G | ASP44 | |
| G | ARG46 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| H | ASP44 | |
| H | ARG46 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1i6p |
| Chain | Residue | Details |
| I | ASP44 | |
| I | ARG46 |
