Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3E2P

Catalytic subunit of M. Jannaschii aspartate transcarbamoylase in an orthorhombic crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0005737	cellular_component	cytoplasm
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0006541	biological_process	glutamine metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0005737	cellular_component	cytoplasm
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0006541	biological_process	glutamine metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C	0005737	cellular_component	cytoplasm
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0006541	biological_process	glutamine metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0004070	molecular_function	aspartate carbamoyltransferase activity
D	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D	0005737	cellular_component	cytoplasm
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006520	biological_process	amino acid metabolic process
D	0006541	biological_process	glutamine metabolic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process
E	0004070	molecular_function	aspartate carbamoyltransferase activity
E	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E	0005737	cellular_component	cytoplasm
E	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006520	biological_process	amino acid metabolic process
E	0006541	biological_process	glutamine metabolic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0044205	biological_process	'de novo' UMP biosynthetic process
F	0004070	molecular_function	aspartate carbamoyltransferase activity
F	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F	0005737	cellular_component	cytoplasm
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006520	biological_process	amino acid metabolic process
F	0006541	biological_process	glutamine metabolic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0044205	biological_process	'de novo' UMP biosynthetic process
I	0004070	molecular_function	aspartate carbamoyltransferase activity
I	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I	0005737	cellular_component	cytoplasm
I	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
I	0006221	biological_process	pyrimidine nucleotide biosynthetic process
I	0006520	biological_process	amino acid metabolic process
I	0006541	biological_process	glutamine metabolic process
I	0016597	molecular_function	amino acid binding
I	0016740	molecular_function	transferase activity
I	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
I	0044205	biological_process	'de novo' UMP biosynthetic process
J	0004070	molecular_function	aspartate carbamoyltransferase activity
J	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J	0005737	cellular_component	cytoplasm
J	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
J	0006221	biological_process	pyrimidine nucleotide biosynthetic process
J	0006520	biological_process	amino acid metabolic process
J	0006541	biological_process	glutamine metabolic process
J	0016597	molecular_function	amino acid binding
J	0016740	molecular_function	transferase activity
J	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
J	0044205	biological_process	'de novo' UMP biosynthetic process
K	0004070	molecular_function	aspartate carbamoyltransferase activity
K	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K	0005737	cellular_component	cytoplasm
K	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
K	0006221	biological_process	pyrimidine nucleotide biosynthetic process
K	0006520	biological_process	amino acid metabolic process
K	0006541	biological_process	glutamine metabolic process
K	0016597	molecular_function	amino acid binding
K	0016740	molecular_function	transferase activity
K	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
K	0044205	biological_process	'de novo' UMP biosynthetic process
L	0004070	molecular_function	aspartate carbamoyltransferase activity
L	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L	0005737	cellular_component	cytoplasm
L	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
L	0006221	biological_process	pyrimidine nucleotide biosynthetic process
L	0006520	biological_process	amino acid metabolic process
L	0006541	biological_process	glutamine metabolic process
L	0016597	molecular_function	amino acid binding
L	0016740	molecular_function	transferase activity
L	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
L	0044205	biological_process	'de novo' UMP biosynthetic process
M	0004070	molecular_function	aspartate carbamoyltransferase activity
M	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M	0005737	cellular_component	cytoplasm
M	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
M	0006221	biological_process	pyrimidine nucleotide biosynthetic process
M	0006520	biological_process	amino acid metabolic process
M	0006541	biological_process	glutamine metabolic process
M	0016597	molecular_function	amino acid binding
M	0016740	molecular_function	transferase activity
M	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
M	0044205	biological_process	'de novo' UMP biosynthetic process
N	0004070	molecular_function	aspartate carbamoyltransferase activity
N	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N	0005737	cellular_component	cytoplasm
N	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
N	0006221	biological_process	pyrimidine nucleotide biosynthetic process
N	0006520	biological_process	amino acid metabolic process
N	0006541	biological_process	glutamine metabolic process
N	0016597	molecular_function	amino acid binding
N	0016740	molecular_function	transferase activity
N	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
N	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 307

Chain	Residue
A	LYS63
A	VAL69
B	LYS63
C	LYS63

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 307

Chain	Residue
D	LYS63
E	LYS63
E	VAL69
F	LYS63

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 I 307

Chain	Residue
I	VAL69
J	LYS63
K	LYS63
K	VAL69
I	LYS63

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 307

Chain	Residue
L	LYS63
L	VAL69
M	LYS63
M	VAL69
N	LYS63

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FyEpSTRT

Chain	Residue	Details
A	PHE47-THR54

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00001

Chain	Residue	Details
A	ARG53
A	PRO264
L	PRO264
M	ARG53
M	THR54
M	LYS82
M	ARG103
M	HIS131
M	GLN134
M	ARG164
M	ARG226
M	LEU263
B	ARG53
M	PRO264
N	ARG53
N	THR54
N	LYS82
N	ARG103
N	HIS131
N	GLN134
N	ARG164
N	ARG226
N	LEU263
B	THR54
N	PRO264
B	LYS82
B	ARG103
B	HIS131
B	GLN134
B	ARG164
B	ARG226
B	LEU263
A	THR54
B	PRO264
C	ARG53
C	THR54
C	LYS82
C	ARG103
C	HIS131
C	GLN134
C	ARG164
C	ARG226
C	LEU263
A	LYS82
C	PRO264
D	ARG53
D	THR54
D	LYS82
D	ARG103
D	HIS131
D	GLN134
D	ARG164
D	ARG226
D	LEU263
A	ARG103
D	PRO264
E	ARG53
E	THR54
E	LYS82
E	ARG103
E	HIS131
E	GLN134
E	ARG164
E	ARG226
E	LEU263
A	HIS131
E	PRO264
F	ARG53
F	THR54
F	LYS82
F	ARG103
F	HIS131
F	GLN134
F	ARG164
F	ARG226
F	LEU263
A	GLN134
F	PRO264
I	ARG53
I	THR54
I	LYS82
I	ARG103
I	HIS131
I	GLN134
I	ARG164
I	ARG226
I	LEU263
A	ARG164
I	PRO264
J	ARG53
J	THR54
J	LYS82
J	ARG103
J	HIS131
J	GLN134
J	ARG164
J	ARG226
J	LEU263
A	ARG226
J	PRO264
K	ARG53
K	THR54
K	LYS82
K	ARG103
K	HIS131
K	GLN134
K	ARG164
K	ARG226
K	LEU263
A	LEU263
K	PRO264
L	ARG53
L	THR54
L	LYS82
L	ARG103
L	HIS131
L	GLN134
L	ARG164
L	ARG226
L	LEU263

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
A	ARG103
A	THR54
A	HIS131
A	ARG53

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
L	ARG103
L	THR54
L	HIS131
L	ARG53

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
M	ARG103
M	THR54
M	HIS131
M	ARG53

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
N	ARG103
N	THR54
N	HIS131
N	ARG53

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
B	ARG103
B	THR54
B	HIS131
B	ARG53

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
C	ARG103
C	THR54
C	HIS131
C	ARG53

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
D	ARG103
D	THR54
D	HIS131
D	ARG53

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
E	ARG103
E	THR54
E	HIS131
E	ARG53

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
F	ARG103
F	THR54
F	HIS131
F	ARG53

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
I	ARG103
I	THR54
I	HIS131
I	ARG53

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
J	ARG103
J	THR54
J	HIS131
J	ARG53

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
K	ARG103
K	THR54
K	HIS131
K	ARG53

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)