3E2A

H. influenzae beta-carbonic anhydrase, variant Y181F with 100 mM bicarbonate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004089	molecular_function	carbonate dehydratase activity
A	0008270	molecular_function	zinc ion binding
A	0015976	biological_process	carbon utilization
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
B	0004089	molecular_function	carbonate dehydratase activity
B	0008270	molecular_function	zinc ion binding
B	0015976	biological_process	carbon utilization
B	0016829	molecular_function	lyase activity
B	0046872	molecular_function	metal ion binding
C	0004089	molecular_function	carbonate dehydratase activity
C	0008270	molecular_function	zinc ion binding
C	0015976	biological_process	carbon utilization
C	0016829	molecular_function	lyase activity
C	0046872	molecular_function	metal ion binding
D	0004089	molecular_function	carbonate dehydratase activity
D	0008270	molecular_function	zinc ion binding
D	0015976	biological_process	carbon utilization
D	0016829	molecular_function	lyase activity
D	0046872	molecular_function	metal ion binding
E	0004089	molecular_function	carbonate dehydratase activity
E	0008270	molecular_function	zinc ion binding
E	0015976	biological_process	carbon utilization
E	0016829	molecular_function	lyase activity
E	0046872	molecular_function	metal ion binding
F	0004089	molecular_function	carbonate dehydratase activity
F	0008270	molecular_function	zinc ion binding
F	0015976	biological_process	carbon utilization
F	0016829	molecular_function	lyase activity
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 230

Chain	Residue
A	CYS42
A	ASP44
A	HIS98
A	CYS101

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 231

Chain	Residue
A	ARG124
A	PHE128
B	ARG160
B	ARG198

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 232

Chain	Residue
A	VAL47
A	HIS98
A	THR99
A	PHE181
A	VAL183
A	ARG46

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 230

Chain	Residue
B	CYS42
B	ASP44
B	HIS98
B	CYS101

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 231

Chain	Residue
A	ARG160
A	ARG198
B	LEU121
B	ARG124

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 232

Chain	Residue
B	ASP44
B	SER45
B	ARG46
B	VAL47
B	HIS98
B	VAL183

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 230

Chain	Residue
C	CYS42
C	ASP44
C	HIS98
C	CYS101

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 231

Chain	Residue
C	ARG160
C	ARG198
D	LEU121
D	ARG124

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 232

Chain	Residue
C	ASP44
C	SER45
C	ARG46
C	VAL47
C	HIS98
C	PHE181
C	VAL183

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 230

Chain	Residue
D	CYS42
D	ASP44
D	HIS98
D	CYS101

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 231

Chain	Residue
C	LEU121
C	ARG124
D	ARG160
D	ARG198

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 232

Chain	Residue
D	SER45
D	ARG46
D	VAL47
D	HIS98
D	PHE181
D	VAL183

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 230

Chain	Residue
E	CYS42
E	ASP44
E	HIS98
E	CYS101

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 231

Chain	Residue
E	ARG160
E	LYS165
E	ARG198
F	LEU121
F	ARG124
F	PHE128

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 232

Chain	Residue
E	LEU121
E	ARG124
E	PHE128
F	ARG160
F	ARG198

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 233

Chain	Residue
E	SER45
E	ARG46
E	VAL47
E	HIS98
E	PHE181
E	VAL183

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 230

Chain	Residue
F	CYS42
F	ASP44
F	HIS98
F	CYS101

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 231

Chain	Residue
F	SER45
F	ARG46
F	HIS98
F	THR99
F	PHE181
F	VAL183

---

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BCT F 232

Chain	Residue
D	ARG64
D	HOH240
F	PRO48
F	ALA49
F	GLU50
F	ARG64
F	HOH259

---

Functional Information from PROSITE/UniProt

site_id	PS00704
Number of Residues	8
Details	PROK_CO2_ANHYDRASE_1 Prokaryotic-type carbonic anhydrases signature 1. CSDSRVpA

Chain	Residue	Details
A	CYS42-ALA49

---

site_id	PS00705
Number of Residues	21
Details	PROK_CO2_ANHYDRASE_2 Prokaryotic-type carbonic anhydrases signature 2. QYAVdvLkiehIIIcGHtnCG

Chain	Residue	Details
A	GLN82-GLY102

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16584170","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A8D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1i6p

Chain	Residue	Details
A	ASP44
A	ARG46

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1i6p

Chain	Residue	Details
B	ASP44
B	ARG46

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1i6p

Chain	Residue	Details
C	ASP44
C	ARG46

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1i6p

Chain	Residue	Details
D	ASP44
D	ARG46

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1i6p

Chain	Residue	Details
E	ASP44
E	ARG46

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1i6p

Chain	Residue	Details
F	ASP44
F	ARG46

---