3E08
H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
A | 0006569 | biological_process | tryptophan catabolic process |
A | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
A | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
A | 0020037 | molecular_function | heme binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0051213 | molecular_function | dioxygenase activity |
B | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
B | 0006569 | biological_process | tryptophan catabolic process |
B | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
B | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
B | 0020037 | molecular_function | heme binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0051213 | molecular_function | dioxygenase activity |
C | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
C | 0006569 | biological_process | tryptophan catabolic process |
C | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
C | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
C | 0020037 | molecular_function | heme binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0051213 | molecular_function | dioxygenase activity |
D | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
D | 0006569 | biological_process | tryptophan catabolic process |
D | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
D | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
D | 0020037 | molecular_function | heme binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0051213 | molecular_function | dioxygenase activity |
E | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
E | 0006569 | biological_process | tryptophan catabolic process |
E | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
E | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
E | 0020037 | molecular_function | heme binding |
E | 0046872 | molecular_function | metal ion binding |
E | 0051213 | molecular_function | dioxygenase activity |
F | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
F | 0006569 | biological_process | tryptophan catabolic process |
F | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
F | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
F | 0020037 | molecular_function | heme binding |
F | 0046872 | molecular_function | metal ion binding |
F | 0051213 | molecular_function | dioxygenase activity |
G | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
G | 0006569 | biological_process | tryptophan catabolic process |
G | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
G | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
G | 0020037 | molecular_function | heme binding |
G | 0046872 | molecular_function | metal ion binding |
G | 0051213 | molecular_function | dioxygenase activity |
H | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
H | 0006569 | biological_process | tryptophan catabolic process |
H | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
H | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
H | 0020037 | molecular_function | heme binding |
H | 0046872 | molecular_function | metal ion binding |
H | 0051213 | molecular_function | dioxygenase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TRP A 402 |
Chain | Residue |
A | PHE51 |
A | HOH405 |
B | TYR24 |
A | SER55 |
A | TYR113 |
A | ARG117 |
A | SER123 |
A | SER124 |
A | GLY253 |
A | THR254 |
A | HEM401 |
site_id | AC2 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE HEM A 401 |
Chain | Residue |
A | GLN54 |
A | SER55 |
A | SER58 |
A | TRP102 |
A | LEU105 |
A | SER124 |
A | GLY125 |
A | PHE126 |
A | TYR131 |
A | ARG132 |
A | HIS240 |
A | VAL244 |
A | VAL247 |
A | GLY253 |
A | THR254 |
A | GLY255 |
A | GLY256 |
A | SER257 |
A | LEU263 |
A | TRP402 |
A | HOH405 |
A | HOH413 |
A | HOH434 |
B | ARG8 |
site_id | AC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TRP A 403 |
Chain | Residue |
A | ARG85 |
A | LYS92 |
A | SER221 |
A | GLU224 |
A | ASP225 |
A | ASP228 |
A | HOH419 |
A | HOH435 |
A | HOH532 |
A | HOH556 |
A | HOH669 |
C | LYS86 |
site_id | AC4 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE HEM B 401 |
Chain | Residue |
A | ARG8 |
A | TYR24 |
B | GLN54 |
B | SER55 |
B | TRP102 |
B | LEU105 |
B | SER124 |
B | GLY125 |
B | PHE126 |
B | TYR131 |
B | ARG132 |
B | HIS240 |
B | VAL244 |
B | VAL247 |
B | GLY253 |
B | THR254 |
B | GLY255 |
B | GLY256 |
B | SER257 |
B | LEU263 |
B | TRP402 |
B | HOH550 |
B | HOH555 |
B | HOH559 |
site_id | AC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TRP B 402 |
Chain | Residue |
A | TYR24 |
B | PHE51 |
B | SER55 |
B | TYR113 |
B | ARG117 |
B | SER123 |
B | SER124 |
B | GLY253 |
B | THR254 |
B | HEM401 |
B | HOH550 |
site_id | AC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRP B 403 |
Chain | Residue |
B | ARG85 |
B | LYS92 |
B | SER221 |
B | ASP225 |
B | ASP228 |
B | HOH554 |
B | HOH603 |
B | HOH648 |
B | HOH654 |
D | LYS86 |
site_id | AC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRP C 403 |
Chain | Residue |
C | HOH655 |
C | HOH760 |
C | HOH764 |
A | LYS86 |
A | ALA89 |
C | LYS92 |
C | SER221 |
C | ASP228 |
C | HOH627 |
C | HOH644 |
site_id | AC8 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TRP C 402 |
Chain | Residue |
C | PHE51 |
C | SER55 |
C | TYR113 |
C | ARG117 |
C | SER123 |
C | SER124 |
C | GLY253 |
C | THR254 |
C | HEM401 |
C | HOH643 |
D | TYR24 |
site_id | AC9 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE HEM C 401 |
Chain | Residue |
C | GLN54 |
C | SER55 |
C | TRP102 |
C | LEU105 |
C | SER124 |
C | GLY125 |
C | PHE126 |
C | TYR131 |
C | ARG132 |
C | HIS240 |
C | VAL244 |
C | VAL247 |
C | GLY253 |
C | THR254 |
C | GLY255 |
C | SER257 |
C | LEU263 |
C | TRP402 |
C | HOH643 |
C | HOH646 |
C | HOH666 |
D | ARG8 |
D | TYR24 |
site_id | BC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TRP D 403 |
Chain | Residue |
B | LYS86 |
D | ARG85 |
D | LYS92 |
D | SER221 |
D | ASP225 |
D | ASP228 |
D | HOH630 |
D | HOH657 |
D | HOH727 |
D | HOH741 |
D | HOH823 |
site_id | BC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TRP D 402 |
Chain | Residue |
C | TYR24 |
D | PHE51 |
D | SER55 |
D | TYR113 |
D | ARG117 |
D | SER123 |
D | SER124 |
D | GLY253 |
D | THR254 |
D | HEM401 |
D | HOH629 |
site_id | BC3 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE HEM D 401 |
Chain | Residue |
C | ARG8 |
C | TYR24 |
D | GLN54 |
D | SER55 |
D | TRP102 |
D | LEU105 |
D | SER124 |
D | GLY125 |
D | PHE126 |
D | TYR131 |
D | ARG132 |
D | HIS240 |
D | VAL244 |
D | VAL247 |
D | GLY253 |
D | THR254 |
D | GLY255 |
D | GLY256 |
D | SER257 |
D | LEU263 |
D | TRP402 |
D | HOH629 |
D | HOH679 |
D | HOH680 |
site_id | BC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRP E 402 |
Chain | Residue |
E | PHE51 |
E | SER55 |
E | TYR113 |
E | ARG117 |
E | SER123 |
E | GLY253 |
E | THR254 |
E | HEM401 |
E | HOH408 |
F | TYR24 |
site_id | BC5 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE HEM E 401 |
Chain | Residue |
E | GLN54 |
E | SER55 |
E | TRP102 |
E | LEU105 |
E | SER124 |
E | GLY125 |
E | PHE126 |
E | TYR131 |
E | ARG132 |
E | HIS240 |
E | VAL244 |
E | VAL247 |
E | ILE248 |
E | GLY253 |
E | GLY255 |
E | SER257 |
E | TRP402 |
E | HOH408 |
E | HOH427 |
E | HOH442 |
F | ARG8 |
F | TYR24 |
site_id | BC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRP E 403 |
Chain | Residue |
E | ARG85 |
E | LYS92 |
E | TYR220 |
E | SER221 |
E | ASP225 |
E | ASP228 |
E | HOH417 |
E | HOH467 |
E | HOH512 |
G | LYS86 |
site_id | BC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRP F 402 |
Chain | Residue |
E | TYR24 |
F | PHE51 |
F | TYR113 |
F | ARG117 |
F | SER123 |
F | SER124 |
F | GLY253 |
F | THR254 |
F | HEM401 |
F | HOH503 |
site_id | BC8 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE HEM F 401 |
Chain | Residue |
E | ARG8 |
E | TYR24 |
F | GLN54 |
F | SER55 |
F | TRP102 |
F | LEU105 |
F | SER124 |
F | GLY125 |
F | PHE126 |
F | TYR131 |
F | ARG132 |
F | HIS240 |
F | VAL244 |
F | VAL247 |
F | ILE248 |
F | GLY253 |
F | GLY255 |
F | GLY256 |
F | SER257 |
F | LEU263 |
F | TRP402 |
F | HOH442 |
F | HOH503 |
F | HOH529 |
site_id | BC9 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE TRP F 403 |
Chain | Residue |
F | LYS92 |
F | SER221 |
F | GLU224 |
F | ASP225 |
F | ASP228 |
F | HOH468 |
F | HOH512 |
F | HOH573 |
H | LYS86 |
site_id | CC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE TRP G 403 |
Chain | Residue |
E | LYS86 |
G | ARG85 |
G | LYS92 |
G | SER221 |
G | ASP228 |
G | HOH457 |
G | HOH473 |
G | HOH475 |
G | HOH477 |
site_id | CC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRP G 402 |
Chain | Residue |
G | PHE51 |
G | SER55 |
G | TYR113 |
G | ARG117 |
G | SER123 |
G | GLY253 |
G | THR254 |
G | HEM401 |
G | HOH415 |
H | TYR24 |
site_id | CC3 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE HEM G 401 |
Chain | Residue |
G | GLN54 |
G | SER55 |
G | TRP102 |
G | LEU105 |
G | SER124 |
G | GLY125 |
G | PHE126 |
G | TYR131 |
G | ARG132 |
G | HIS240 |
G | VAL244 |
G | VAL247 |
G | ILE248 |
G | GLY253 |
G | THR254 |
G | GLY255 |
G | SER257 |
G | LEU263 |
G | ALA266 |
G | TRP402 |
G | HOH415 |
G | HOH503 |
G | HOH523 |
H | ARG8 |
H | TYR24 |
site_id | CC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TRP H 403 |
Chain | Residue |
F | LYS86 |
H | ARG85 |
H | LYS92 |
H | SER221 |
H | GLU224 |
H | ASP228 |
H | HOH675 |
H | HOH690 |
H | HOH794 |
H | HOH795 |
H | HOH860 |
site_id | CC5 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TRP H 402 |
Chain | Residue |
G | TYR24 |
H | PHE51 |
H | SER55 |
H | TYR113 |
H | ARG117 |
H | LEU120 |
H | SER123 |
H | SER124 |
H | GLY253 |
H | THR254 |
H | HEM401 |
H | HOH662 |
site_id | CC6 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE HEM H 401 |
Chain | Residue |
G | ARG8 |
G | TYR24 |
H | GLN54 |
H | SER55 |
H | TRP102 |
H | SER124 |
H | GLY125 |
H | PHE126 |
H | TYR131 |
H | ARG132 |
H | HIS240 |
H | VAL244 |
H | VAL247 |
H | ILE248 |
H | GLY253 |
H | GLY255 |
H | SER257 |
H | GLY259 |
H | LEU263 |
H | TRP402 |
H | HOH662 |
H | HOH710 |
H | HOH763 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01972, ECO:0000269|PubMed:17197414, ECO:0000269|PubMed:18783250, ECO:0007744|PDB:2NW8, ECO:0007744|PDB:3BK9 |
Chain | Residue | Details |
A | PHE51 | |
B | PHE51 | |
C | PHE51 | |
D | PHE51 | |
E | PHE51 | |
F | PHE51 | |
G | PHE51 | |
H | PHE51 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01972, ECO:0000269|PubMed:17197414, ECO:0000269|PubMed:18783250, ECO:0007744|PDB:2NW8, ECO:0007744|PDB:3BK9, ECO:0007744|PDB:3E08 |
Chain | Residue | Details |
A | TYR113 | |
D | TYR113 | |
D | ARG117 | |
D | THR254 | |
E | TYR113 | |
E | ARG117 | |
E | THR254 | |
F | TYR113 | |
F | ARG117 | |
F | THR254 | |
G | TYR113 | |
A | ARG117 | |
G | ARG117 | |
G | THR254 | |
H | TYR113 | |
H | ARG117 | |
H | THR254 | |
A | THR254 | |
B | TYR113 | |
B | ARG117 | |
B | THR254 | |
C | TYR113 | |
C | ARG117 | |
C | THR254 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: axial binding residue => ECO:0000255|HAMAP-Rule:MF_01972, ECO:0000269|PubMed:17197414, ECO:0000269|PubMed:18783250, ECO:0007744|PDB:2NW7, ECO:0007744|PDB:2NW8, ECO:0007744|PDB:2NW9, ECO:0007744|PDB:3BK9, ECO:0007744|PDB:3E08 |
Chain | Residue | Details |
A | HIS240 | |
B | HIS240 | |
C | HIS240 | |
D | HIS240 | |
E | HIS240 | |
F | HIS240 | |
G | HIS240 | |
H | HIS240 |