Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3E08

H55S mutant Xanthomonas campestris tryptophan 2,3-dioxygenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
A	0006569	biological_process	L-tryptophan catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0019441	biological_process	L-tryptophan catabolic process to kynurenine
A	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
B	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
B	0006569	biological_process	L-tryptophan catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0019441	biological_process	L-tryptophan catabolic process to kynurenine
B	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
C	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
C	0006569	biological_process	L-tryptophan catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0019441	biological_process	L-tryptophan catabolic process to kynurenine
C	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
D	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
D	0006569	biological_process	L-tryptophan catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0019441	biological_process	L-tryptophan catabolic process to kynurenine
D	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity
E	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
E	0006569	biological_process	L-tryptophan catabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0019441	biological_process	L-tryptophan catabolic process to kynurenine
E	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
E	0020037	molecular_function	heme binding
E	0046872	molecular_function	metal ion binding
E	0051213	molecular_function	dioxygenase activity
F	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
F	0006569	biological_process	L-tryptophan catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0019441	biological_process	L-tryptophan catabolic process to kynurenine
F	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
F	0020037	molecular_function	heme binding
F	0046872	molecular_function	metal ion binding
F	0051213	molecular_function	dioxygenase activity
G	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
G	0006569	biological_process	L-tryptophan catabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0019441	biological_process	L-tryptophan catabolic process to kynurenine
G	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
G	0020037	molecular_function	heme binding
G	0046872	molecular_function	metal ion binding
G	0051213	molecular_function	dioxygenase activity
H	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
H	0006569	biological_process	L-tryptophan catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0019441	biological_process	L-tryptophan catabolic process to kynurenine
H	0019442	biological_process	L-tryptophan catabolic process to acetyl-CoA
H	0020037	molecular_function	heme binding
H	0046872	molecular_function	metal ion binding
H	0051213	molecular_function	dioxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TRP A 402

Chain	Residue
A	PHE51
A	HOH405
B	TYR24
A	SER55
A	TYR113
A	ARG117
A	SER123
A	SER124
A	GLY253
A	THR254
A	HEM401

site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM A 401

Chain	Residue
A	GLN54
A	SER55
A	SER58
A	TRP102
A	LEU105
A	SER124
A	GLY125
A	PHE126
A	TYR131
A	ARG132
A	HIS240
A	VAL244
A	VAL247
A	GLY253
A	THR254
A	GLY255
A	GLY256
A	SER257
A	LEU263
A	TRP402
A	HOH405
A	HOH413
A	HOH434
B	ARG8

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TRP A 403

Chain	Residue
A	ARG85
A	LYS92
A	SER221
A	GLU224
A	ASP225
A	ASP228
A	HOH419
A	HOH435
A	HOH532
A	HOH556
A	HOH669
C	LYS86

site_id	AC4
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM B 401

Chain	Residue
A	ARG8
A	TYR24
B	GLN54
B	SER55
B	TRP102
B	LEU105
B	SER124
B	GLY125
B	PHE126
B	TYR131
B	ARG132
B	HIS240
B	VAL244
B	VAL247
B	GLY253
B	THR254
B	GLY255
B	GLY256
B	SER257
B	LEU263
B	TRP402
B	HOH550
B	HOH555
B	HOH559

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TRP B 402

Chain	Residue
A	TYR24
B	PHE51
B	SER55
B	TYR113
B	ARG117
B	SER123
B	SER124
B	GLY253
B	THR254
B	HEM401
B	HOH550

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TRP B 403

Chain	Residue
B	ARG85
B	LYS92
B	SER221
B	ASP225
B	ASP228
B	HOH554
B	HOH603
B	HOH648
B	HOH654
D	LYS86

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TRP C 403

Chain	Residue
C	HOH655
C	HOH760
C	HOH764
A	LYS86
A	ALA89
C	LYS92
C	SER221
C	ASP228
C	HOH627
C	HOH644

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TRP C 402

Chain	Residue
C	PHE51
C	SER55
C	TYR113
C	ARG117
C	SER123
C	SER124
C	GLY253
C	THR254
C	HEM401
C	HOH643
D	TYR24

site_id	AC9
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM C 401

Chain	Residue
C	GLN54
C	SER55
C	TRP102
C	LEU105
C	SER124
C	GLY125
C	PHE126
C	TYR131
C	ARG132
C	HIS240
C	VAL244
C	VAL247
C	GLY253
C	THR254
C	GLY255
C	SER257
C	LEU263
C	TRP402
C	HOH643
C	HOH646
C	HOH666
D	ARG8
D	TYR24

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TRP D 403

Chain	Residue
B	LYS86
D	ARG85
D	LYS92
D	SER221
D	ASP225
D	ASP228
D	HOH630
D	HOH657
D	HOH727
D	HOH741
D	HOH823

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TRP D 402

Chain	Residue
C	TYR24
D	PHE51
D	SER55
D	TYR113
D	ARG117
D	SER123
D	SER124
D	GLY253
D	THR254
D	HEM401
D	HOH629

site_id	BC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM D 401

Chain	Residue
C	ARG8
C	TYR24
D	GLN54
D	SER55
D	TRP102
D	LEU105
D	SER124
D	GLY125
D	PHE126
D	TYR131
D	ARG132
D	HIS240
D	VAL244
D	VAL247
D	GLY253
D	THR254
D	GLY255
D	GLY256
D	SER257
D	LEU263
D	TRP402
D	HOH629
D	HOH679
D	HOH680

site_id	BC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TRP E 402

Chain	Residue
E	PHE51
E	SER55
E	TYR113
E	ARG117
E	SER123
E	GLY253
E	THR254
E	HEM401
E	HOH408
F	TYR24

site_id	BC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM E 401

Chain	Residue
E	GLN54
E	SER55
E	TRP102
E	LEU105
E	SER124
E	GLY125
E	PHE126
E	TYR131
E	ARG132
E	HIS240
E	VAL244
E	VAL247
E	ILE248
E	GLY253
E	GLY255
E	SER257
E	TRP402
E	HOH408
E	HOH427
E	HOH442
F	ARG8
F	TYR24

site_id	BC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TRP E 403

Chain	Residue
E	ARG85
E	LYS92
E	TYR220
E	SER221
E	ASP225
E	ASP228
E	HOH417
E	HOH467
E	HOH512
G	LYS86

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TRP F 402

Chain	Residue
E	TYR24
F	PHE51
F	TYR113
F	ARG117
F	SER123
F	SER124
F	GLY253
F	THR254
F	HEM401
F	HOH503

site_id	BC8
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM F 401

Chain	Residue
E	ARG8
E	TYR24
F	GLN54
F	SER55
F	TRP102
F	LEU105
F	SER124
F	GLY125
F	PHE126
F	TYR131
F	ARG132
F	HIS240
F	VAL244
F	VAL247
F	ILE248
F	GLY253
F	GLY255
F	GLY256
F	SER257
F	LEU263
F	TRP402
F	HOH442
F	HOH503
F	HOH529

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TRP F 403

Chain	Residue
F	LYS92
F	SER221
F	GLU224
F	ASP225
F	ASP228
F	HOH468
F	HOH512
F	HOH573
H	LYS86

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TRP G 403

Chain	Residue
E	LYS86
G	ARG85
G	LYS92
G	SER221
G	ASP228
G	HOH457
G	HOH473
G	HOH475
G	HOH477

site_id	CC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TRP G 402

Chain	Residue
G	PHE51
G	SER55
G	TYR113
G	ARG117
G	SER123
G	GLY253
G	THR254
G	HEM401
G	HOH415
H	TYR24

site_id	CC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM G 401

Chain	Residue
G	GLN54
G	SER55
G	TRP102
G	LEU105
G	SER124
G	GLY125
G	PHE126
G	TYR131
G	ARG132
G	HIS240
G	VAL244
G	VAL247
G	ILE248
G	GLY253
G	THR254
G	GLY255
G	SER257
G	LEU263
G	ALA266
G	TRP402
G	HOH415
G	HOH503
G	HOH523
H	ARG8
H	TYR24

site_id	CC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TRP H 403

Chain	Residue
F	LYS86
H	ARG85
H	LYS92
H	SER221
H	GLU224
H	ASP228
H	HOH675
H	HOH690
H	HOH794
H	HOH795
H	HOH860

site_id	CC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TRP H 402

Chain	Residue
G	TYR24
H	PHE51
H	SER55
H	TYR113
H	ARG117
H	LEU120
H	SER123
H	SER124
H	GLY253
H	THR254
H	HEM401
H	HOH662

site_id	CC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM H 401

Chain	Residue
G	ARG8
G	TYR24
H	GLN54
H	SER55
H	TRP102
H	SER124
H	GLY125
H	PHE126
H	TYR131
H	ARG132
H	HIS240
H	VAL244
H	VAL247
H	ILE248
H	GLY253
H	GLY255
H	SER257
H	GLY259
H	LEU263
H	TRP402
H	HOH662
H	HOH710
H	HOH763

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01972","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17197414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18783250","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2NW8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BK9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01972","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17197414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18783250","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2NW8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BK9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E08","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"HAMAP-Rule","id":"MF_01972","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17197414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18783250","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2NW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BK9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E08","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)