3DZ5

Human AdoMetDC with covalently bound 5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004014	molecular_function	adenosylmethionine decarboxylase activity
A	0006597	biological_process	spermine biosynthetic process
A	0008295	biological_process	spermidine biosynthetic process
B	0004014	molecular_function	adenosylmethionine decarboxylase activity
B	0008295	biological_process	spermidine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PUT B 350

Chain	Residue
A	PHE111
A	ASP174
A	THR176
A	PHE285
A	HOH370
B	LEU13
B	GLU15

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site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE M8M A 368

Chain	Residue
A	PHE223
A	ASN224
A	CYS226
A	GLY227
A	TYR228
A	SER229
A	HIS243
A	ILE244
A	THR245
A	PRO246
A	GLU247
B	PHE7
B	LEU65
B	SER66
B	GLU67
A	PYR68
A	SER69

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"1917972","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor; for catalytic activity","evidences":[{"source":"PubMed","id":"10029540","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Proton acceptor; for processing activity","evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 575

Chain	Residue	Details
B	SER19	proton shuttle (general acid/base)

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