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3DYL

human phosphdiesterase 9 substrate complex (ES complex)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 901
ChainResidue
AHIS256
AHIS292
AASP293
AASP402
AHOH1000

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 902
ChainResidue
AHOH1005
AASP293
AHOH1000
AHOH1003
AHOH1004

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN B 901
ChainResidue
BHOH0
BHIS256
BHIS292
BASP293
BASP402

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 902
ChainResidue
BHOH0
BHOH2
BHOH3
BHOH4
BHOH5
BASP293

site_idAC5
Number of Residues15
DetailsBINDING SITE FOR RESIDUE PCG A 900
ChainResidue
AHOH25
AHOH131
AHIS252
AHIS256
AASP293
AASP402
AILE403
ALEU420
ATYR424
AALA452
AGLN453
APHE456
AHOH1000
AHOH1003
AHOH1005

site_idAC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE IBM B 900
ChainResidue
AILE496
AMET500
BHOH28
BHOH36
BLEU420
BTYR424
BALA452
BGLN453
BPHE456

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE FMT B 1
ChainResidue
BHOH0
BHOH2
BHOH33
BPHE251
BHIS252
BHIS256
BASP293
BASP402

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGynNtY
ChainResidueDetails
AHIS292-TYR303

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000269|PubMed:18757755
ChainResidueDetails
AHIS252
BHIS252

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:18757755
ChainResidueDetails
AHIS252
ATYR424
AALA452
BHIS252
BTYR424
BALA452

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18757755, ECO:0000269|PubMed:19919087, ECO:0000269|PubMed:20121115, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:22985069, ECO:0000269|PubMed:23025719, ECO:0007744|PDB:2HD1, ECO:0007744|PDB:2YY2, ECO:0007744|PDB:3DYN, ECO:0007744|PDB:3JSI, ECO:0007744|PDB:3JSW, ECO:0007744|PDB:3K3E, ECO:0007744|PDB:3K3H, ECO:0007744|PDB:3N3Z, ECO:0007744|PDB:4E90, ECO:0007744|PDB:4G2J, ECO:0007744|PDB:4G2L, ECO:0007744|PDB:4GH6
ChainResidueDetails
AHIS256
AHIS292
AASP293
AASP402
BHIS256
BHIS292
BASP293
BASP402

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8QZV1
ChainResidueDetails
ASER319
BSER319

223532

PDB entries from 2024-08-07

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