3DYF
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461 and Isopentyl Diphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | geranyltranstransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | geranyltranstransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 3002 |
| Chain | Residue |
| A | ASP103 |
| A | ASP107 |
| A | HOH5225 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 3003 |
| Chain | Residue |
| A | ASP255 |
| A | HOH5001 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 3004 |
| Chain | Residue |
| A | HOH5003 |
| A | ASP103 |
| A | ASP107 |
| A | ASP175 |
| A | HOH5002 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG B 4002 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 4003 |
| Chain | Residue |
| B | ASP255 |
| B | HOH5161 |
| B | HOH5264 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 4004 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | ASP175 |
| B | HOH5004 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NI9 A 3001 |
| Chain | Residue |
| A | TYR99 |
| A | ASP103 |
| A | ASP107 |
| A | ARG112 |
| A | GLN172 |
| A | LYS212 |
| A | THR213 |
| A | TYR216 |
| A | GLN252 |
| A | ASP255 |
| A | LYS269 |
| A | HOH5001 |
| A | HOH5003 |
| A | HOH5060 |
| A | HOH5143 |
| A | HOH5225 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE NI9 B 4001 |
| Chain | Residue |
| B | TYR99 |
| B | ASP103 |
| B | ASP107 |
| B | ARG112 |
| B | GLN172 |
| B | LYS212 |
| B | THR213 |
| B | ASP255 |
| B | LYS269 |
| B | HOH5004 |
| B | HOH5116 |
| B | HOH5117 |
| B | HOH5161 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME B 9001 |
| Chain | Residue |
| B | CYS159 |
| B | ARG160 |
| B | ARG163 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IPR B 6002 |
| Chain | Residue |
| B | LYS47 |
| B | ARG50 |
| B | GLN96 |
| B | ARG113 |
| B | TYR216 |
| B | PHE251 |
| B | GLN252 |
| B | ASP255 |
| B | ARG365 |
| B | HOH5045 |
| B | HOH5112 |
| B | HOH5275 |
| site_id | BC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE IPR A 6001 |
| Chain | Residue |
| A | GLY46 |
| A | LYS47 |
| A | ARG50 |
| A | GLN96 |
| A | ARG113 |
| A | TYR216 |
| A | THR217 |
| A | PHE251 |
| A | GLN252 |
| A | ASP255 |
| A | HOH5006 |
| A | HOH5022 |
| A | HOH5149 |
| A | HOH5151 |
| A | HOH5242 |
| A | HOH5252 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD A 7001 |
| Chain | Residue |
| A | ARG163 |
| A | THR167 |
| A | TYR215 |
| A | HOH5294 |
| B | LYS24 |
Functional Information from PROSITE/UniProt
