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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3DWW

Electron crystallographic structure of human microsomal prostaglandin E synthase 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001516biological_processprostaglandin biosynthetic process
A0004364molecular_functionglutathione transferase activity
A0004602molecular_functionglutathione peroxidase activity
A0004667molecular_functionprostaglandin-D synthase activity
A0005515molecular_functionprotein binding
A0005641cellular_componentnuclear envelope lumen
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0006693biological_processprostaglandin metabolic process
A0007165biological_processsignal transduction
A0008283biological_processcell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016853molecular_functionisomerase activity
A0019233biological_processsensory perception of pain
A0019371biological_processcyclooxygenase pathway
A0031620biological_processregulation of fever generation
A0032308biological_processpositive regulation of prostaglandin secretion
A0043295molecular_functionglutathione binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050220molecular_functionprostaglandin-E synthase activity
A0050727biological_processregulation of inflammatory response
A0098869biological_processcellular oxidant detoxification
B0001516biological_processprostaglandin biosynthetic process
B0004364molecular_functionglutathione transferase activity
B0004602molecular_functionglutathione peroxidase activity
B0004667molecular_functionprostaglandin-D synthase activity
B0005515molecular_functionprotein binding
B0005641cellular_componentnuclear envelope lumen
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0006693biological_processprostaglandin metabolic process
B0007165biological_processsignal transduction
B0008283biological_processcell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016853molecular_functionisomerase activity
B0019233biological_processsensory perception of pain
B0019371biological_processcyclooxygenase pathway
B0031620biological_processregulation of fever generation
B0032308biological_processpositive regulation of prostaglandin secretion
B0043295molecular_functionglutathione binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050220molecular_functionprostaglandin-E synthase activity
B0050727biological_processregulation of inflammatory response
B0098869biological_processcellular oxidant detoxification
C0001516biological_processprostaglandin biosynthetic process
C0004364molecular_functionglutathione transferase activity
C0004602molecular_functionglutathione peroxidase activity
C0004667molecular_functionprostaglandin-D synthase activity
C0005515molecular_functionprotein binding
C0005641cellular_componentnuclear envelope lumen
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0006629biological_processlipid metabolic process
C0006631biological_processfatty acid metabolic process
C0006633biological_processfatty acid biosynthetic process
C0006693biological_processprostaglandin metabolic process
C0007165biological_processsignal transduction
C0008283biological_processcell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0016740molecular_functiontransferase activity
C0016853molecular_functionisomerase activity
C0019233biological_processsensory perception of pain
C0019371biological_processcyclooxygenase pathway
C0031620biological_processregulation of fever generation
C0032308biological_processpositive regulation of prostaglandin secretion
C0043295molecular_functionglutathione binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050220molecular_functionprostaglandin-E synthase activity
C0050727biological_processregulation of inflammatory response
C0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GSH C 153
ChainResidue
ATYR28
CTYR117
CARG126
CTYR130
CGLN134
AALA31
ATHR34
AGLY35
AHIS72
CASN74
CGLU77
CARG110
CHIS113
site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GSH A 154
ChainResidue
AARG70
AGLU77
AARG110
AHIS113
ATYR117
AARG126
ATYR130
BTYR28
BALA31
BTHR34
BGLY35
BARG38
BHIS72
site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GSH B 155
ChainResidue
BASN74
BGLU77
BARG110
BHIS113
BTYR117
BARG126
BTYR130
CTYR28
CALA31
CTHR34
CGLY35
CARG38
CCYS68
CHIS72
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues324
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues63
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues12
DetailsTopological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues33
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18682561","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YL3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BQI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5T36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5T37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TL9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsSite: {"description":"Essential for protaglandin-E synthase activity","evidences":[{"source":"PubMed","id":"26755582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27684486","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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