3DWS
Leishmania major Coproporphyrinogen III Oxidase with bound ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004109 | molecular_function | coproporphyrinogen oxidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0004109 | molecular_function | coproporphyrinogen oxidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| B | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| B | 0006783 | biological_process | heme biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 302 |
| Chain | Residue |
| A | HIS107 |
| A | ARG181 |
| A | TYR241 |
| A | ASN245 |
| A | SER268 |
| A | HOH347 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 302 |
| Chain | Residue |
| B | ASN245 |
| B | SER268 |
| B | HOH337 |
| B | HIS107 |
| B | ARG181 |
| B | TYR241 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 303 |
| Chain | Residue |
| B | PRO122 |
| B | TRP124 |
| B | ASN192 |
| B | HOH568 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FIC A 303 |
| Chain | Residue |
| A | SER93 |
| A | HIS107 |
| A | ASN109 |
| A | ARG111 |
| A | GLY251 |
| A | HOH504 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FIC B 304 |
| Chain | Residue |
| B | SER93 |
| B | HIS107 |
| B | ASN109 |
| B | ARG111 |
| B | GLY251 |
| B | HOH546 |
| B | HOH566 |
Functional Information from PROSITE/UniProt
| site_id | PS01021 |
| Number of Residues | 25 |
| Details | COPROGEN_OXIDASE Coproporphyrinogen III oxidase signature. KgWCdeYFfIpYRnEaRGIGGLFFD |
| Chain | Residue | Details |
| A | LYS165-ASP189 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | Region: {"description":"Important for dimerization","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {} |
| Chain | Residue | Details |
