3DWR
Leishmania major coproporphyrinogen III oxidase with bound ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004109 | molecular_function | coproporphyrinogen oxidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0004109 | molecular_function | coproporphyrinogen oxidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| B | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| B | 0006783 | biological_process | heme biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 402 |
| Chain | Residue |
| A | HIS107 |
| A | ARG181 |
| A | TYR241 |
| A | ASN245 |
| A | HOH631 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 403 |
| Chain | Residue |
| A | PRO225 |
| A | TYR226 |
| A | HOH627 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 404 |
| Chain | Residue |
| A | GLY45 |
| A | PHE63 |
| A | TYR293 |
| A | GLY44 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT A 405 |
| Chain | Residue |
| A | PHE32 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 401 |
| Chain | Residue |
| B | HIS107 |
| B | ARG181 |
| B | TYR241 |
| B | ASN245 |
| B | HOH593 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 0PA A 501 |
| Chain | Residue |
| A | TRP37 |
| A | ARG39 |
| A | ASN62 |
| A | SER64 |
| A | GLY260 |
| A | ARG261 |
| A | HOH650 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 0PA A 502 |
| Chain | Residue |
| A | SER93 |
| A | GLY251 |
| A | THR252 |
| A | SER264 |
| A | ILE265 |
| A | ILE267 |
| A | SER268 |
| A | HOH624 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 0PA A 503 |
| Chain | Residue |
| A | SER64 |
| A | MET90 |
| A | GLY91 |
| A | SER93 |
| A | ASN109 |
| A | HOH628 |
| A | HOH657 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE 0PA B 504 |
| Chain | Residue |
| B | SER64 |
| B | SER258 |
| B | ILE265 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 0PA B 505 |
| Chain | Residue |
| B | ASN62 |
| B | SER93 |
| B | GLY251 |
| B | SER264 |
| B | ILE265 |
| B | ILE267 |
| B | HOH524 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 0PA B 506 |
| Chain | Residue |
| B | SER64 |
| B | MET90 |
| B | SER93 |
| B | ASN109 |
| B | HOH581 |
Functional Information from PROSITE/UniProt
| site_id | PS01021 |
| Number of Residues | 25 |
| Details | COPROGEN_OXIDASE Coproporphyrinogen III oxidase signature. KgWCdeYFfIpYRnEaRGIGGLFFD |
| Chain | Residue | Details |
| A | LYS165-ASP189 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Region: {"description":"Important for dimerization","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {} |
| Chain | Residue | Details |
