3DWI
Crystal structure of Mycobacterium tuberculosis CysM, the cysteine synthase B
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033847 | molecular_function | O-phosphoserine sulfhydrylase activity |
| B | 0004124 | molecular_function | cysteine synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006535 | biological_process | cysteine biosynthetic process from serine |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0033847 | molecular_function | O-phosphoserine sulfhydrylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 324 |
| Chain | Residue |
| A | TYR240 |
| A | SER241 |
| A | ASP246 |
| A | HIS271 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 324 |
| Chain | Residue |
| B | HOH494 |
| B | HOH499 |
| B | THR78 |
| B | SER79 |
| B | GLY80 |
| B | GLN151 |
| B | TYR152 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 325 |
| Chain | Residue |
| B | ARG286 |
| B | HOH481 |
| B | HOH493 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PLP A 401 |
| Chain | Residue |
| A | LYS51 |
| A | ASN81 |
| A | GLY182 |
| A | LEU183 |
| A | GLY184 |
| A | THR185 |
| A | THR186 |
| A | GLY187 |
| A | THR188 |
| A | SER265 |
| A | ALA294 |
| A | ASP295 |
| A | HOH425 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLP B 401 |
| Chain | Residue |
| B | LYS51 |
| B | ASN81 |
| B | GLY182 |
| B | GLY184 |
| B | THR185 |
| B | THR186 |
| B | GLY187 |
| B | THR188 |
| B | ALA218 |
| B | LEU219 |
| B | SER265 |
| B | ALA294 |
| B | ASP295 |
| B | HOH441 |
Functional Information from PROSITE/UniProt
| site_id | PS00901 |
| Number of Residues | 19 |
| Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KlEdrn.PTgSIKdRpAvrM |
| Chain | Residue | Details |
| A | LYS40-MET58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18771296, ECO:0000269|PubMed:18799456, ECO:0000269|PubMed:19101553 |
| Chain | Residue | Details |
| A | ASN81 | |
| A | SER265 | |
| B | ASN81 | |
| B | SER265 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY184 | |
| B | GLY184 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | ARG220 | |
| B | ARG220 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| A | LYS51 | |
| B | LYS51 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| A | LYS51 | |
| A | SER265 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| B | LYS51 | |
| B | SER265 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| A | LYS51 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| B | LYS51 |
