3DWH
Structural and Functional Analysis of SRA domain
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | ARG431 |
| A | PHE432 |
| A | TRP527 |
| A | ARG528 |
| A | ARG581 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 618 |
| Chain | Residue |
| A | LYS592 |
| A | HOH695 |
| A | HIS412 |
| A | SER415 |
| A | ASN416 |
| A | ARG443 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 619 |
| Chain | Residue |
| A | PHE432 |
| A | ARG433 |
| A | ARG528 |
| A | HOH701 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ALA463 | |
| A | ASP469 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Required to confer preferential recognition of cytosine over thymine |
| Chain | Residue | Details |
| A | THR479 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Required to discriminate between hemimethylated DNA versus symmetrically methylated DNA |
| Chain | Residue | Details |
| A | ASN489 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Required for affinity and specificity for 5-mCpG sequence |
| Chain | Residue | Details |
| A | ARG491 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS546 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447 |
| Chain | Residue | Details |
| A | LYS546 |
