3DWB

structure of human ECE-1 complexed with phosphoramidon

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 771

Chain	Residue
A	HIS607
A	HIS611
A	GLU667

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 5HD A 816

Chain	Residue
A	GLN557

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site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE RDF A 817

Chain	Residue
A	GLU608
A	HIS611
A	GLU667
A	PRO731
A	HIS732
A	ARG738
A	HOH917
A	PHE149
A	ASN566
A	ALA567
A	ILE582
A	HIS607

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVGHELTHAF

Chain	Residue	Details
A	VAL604-PHE613

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000305|PubMed:18992253

Chain	Residue	Details
A	GLU608

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000305|PubMed:18992253

Chain	Residue	Details
A	ASP671

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000269|PubMed:18992253

Chain	Residue	Details
A	HIS607
A	HIS611
A	GLU667

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN166

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site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN187
A	ASN539
A	ASN632
A	ASN651

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN210

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN270
A	ASN316

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site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN362
A	ASN383

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