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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3DT4

The structure of rat cytosolic PEPCK in complex with oxalate and GTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0004550molecular_functionnucleoside diphosphate kinase activity
A0004611molecular_functionphosphoenolpyruvate carboxykinase activity
A0004613molecular_functionphosphoenolpyruvate carboxykinase (GTP) activity
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006094biological_processgluconeogenesis
A0006107biological_processoxaloacetate metabolic process
A0006629biological_processlipid metabolic process
A0009617biological_processresponse to bacterium
A0014823biological_processresponse to activity
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0016829molecular_functionlyase activity
A0016831molecular_functioncarboxy-lyase activity
A0017076molecular_functionpurine nucleotide binding
A0018105biological_processpeptidyl-serine phosphorylation
A0019003molecular_functionGDP binding
A0030145molecular_functionmanganese ion binding
A0031406molecular_functioncarboxylic acid binding
A0031667biological_processresponse to nutrient levels
A0032496biological_processresponse to lipopolysaccharide
A0032868biological_processresponse to insulin
A0032869biological_processcellular response to insulin stimulus
A0033993biological_processresponse to lipid
A0042593biological_processglucose homeostasis
A0042594biological_processresponse to starvation
A0043382biological_processpositive regulation of memory T cell differentiation
A0043648biological_processdicarboxylic acid metabolic process
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046166biological_processglyceraldehyde-3-phosphate biosynthetic process
A0046327biological_processglycerol biosynthetic process from pyruvate
A0046872molecular_functionmetal ion binding
A0046889biological_processpositive regulation of lipid biosynthetic process
A0046890biological_processregulation of lipid biosynthetic process
A0051365biological_processcellular response to potassium ion starvation
A0070365biological_processhepatocyte differentiation
A0070741biological_processresponse to interleukin-6
A0071300biological_processcellular response to retinoic acid
A0071320biological_processcellular response to cAMP
A0071332biological_processcellular response to fructose stimulus
A0071333biological_processcellular response to glucose stimulus
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0071377biological_processcellular response to glucagon stimulus
A0071456biological_processcellular response to hypoxia
A0071474biological_processcellular hyperosmotic response
A0071475biological_processcellular hyperosmotic salinity response
A0071476biological_processcellular hypotonic response
A0071477biological_processcellular hypotonic salinity response
A0071549biological_processcellular response to dexamethasone stimulus
A0072350biological_processtricarboxylic acid metabolic process
A0097403biological_processcellular response to raffinose
A0106264molecular_functionprotein serine kinase activity (using GTP as donor)
A1904628biological_processcellular response to phorbol 13-acetate 12-myristate
A1904640biological_processresponse to methionine
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0004550molecular_functionnucleoside diphosphate kinase activity
C0004611molecular_functionphosphoenolpyruvate carboxykinase activity
C0004613molecular_functionphosphoenolpyruvate carboxykinase (GTP) activity
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0006006biological_processglucose metabolic process
C0006094biological_processgluconeogenesis
C0006107biological_processoxaloacetate metabolic process
C0006629biological_processlipid metabolic process
C0009617biological_processresponse to bacterium
C0014823biological_processresponse to activity
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0016829molecular_functionlyase activity
C0016831molecular_functioncarboxy-lyase activity
C0017076molecular_functionpurine nucleotide binding
C0018105biological_processpeptidyl-serine phosphorylation
C0019003molecular_functionGDP binding
C0030145molecular_functionmanganese ion binding
C0031406molecular_functioncarboxylic acid binding
C0031667biological_processresponse to nutrient levels
C0032496biological_processresponse to lipopolysaccharide
C0032868biological_processresponse to insulin
C0032869biological_processcellular response to insulin stimulus
C0033993biological_processresponse to lipid
C0042593biological_processglucose homeostasis
C0042594biological_processresponse to starvation
C0043382biological_processpositive regulation of memory T cell differentiation
C0043648biological_processdicarboxylic acid metabolic process
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046166biological_processglyceraldehyde-3-phosphate biosynthetic process
C0046327biological_processglycerol biosynthetic process from pyruvate
C0046872molecular_functionmetal ion binding
C0046889biological_processpositive regulation of lipid biosynthetic process
C0046890biological_processregulation of lipid biosynthetic process
C0051365biological_processcellular response to potassium ion starvation
C0070365biological_processhepatocyte differentiation
C0070741biological_processresponse to interleukin-6
C0071300biological_processcellular response to retinoic acid
C0071320biological_processcellular response to cAMP
C0071332biological_processcellular response to fructose stimulus
C0071333biological_processcellular response to glucose stimulus
C0071347biological_processcellular response to interleukin-1
C0071356biological_processcellular response to tumor necrosis factor
C0071377biological_processcellular response to glucagon stimulus
C0071456biological_processcellular response to hypoxia
C0071474biological_processcellular hyperosmotic response
C0071475biological_processcellular hyperosmotic salinity response
C0071476biological_processcellular hypotonic response
C0071477biological_processcellular hypotonic salinity response
C0071549biological_processcellular response to dexamethasone stimulus
C0072350biological_processtricarboxylic acid metabolic process
C0097403biological_processcellular response to raffinose
C0106264molecular_functionprotein serine kinase activity (using GTP as donor)
C1904628biological_processcellular response to phorbol 13-acetate 12-myristate
C1904640biological_processresponse to methionine
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MN A 700
ChainResidue
ALYS244
AHIS264
AASP311
site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MN A 800
ChainResidue
ATHR291
AASP310
site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE OXL A 1000
ChainResidue
AASP311
AARG405
AARG87
ALYS244
AHIS264
ASER286
site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NA C 1100
ChainResidue
CLEU79
CASN208
site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MN C 700
ChainResidue
CLYS244
CHIS264
CASP311
site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MN C 800
ChainResidue
CTHR291
CASP310
site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE OXL C 1000
ChainResidue
CARG87
CLYS244
CHIS264
CSER286
CASP311
CARG405
site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NA A 1100
ChainResidue
ALEU79
AASN208
site_idAC9
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GTP A 900
ChainResidue
AHIS264
APRO285
ASER286
AALA287
ACYS288
AGLY289
ALYS290
ATHR291
AASN292
AASP311
APRO337
AARG405
AARG436
ATRP516
APHE517
APHE525
AGLY529
APHE530
AASN533
site_idBC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GTP C 900
ChainResidue
CHIS264
CPRO285
CSER286
CALA287
CCYS288
CGLY289
CLYS290
CTHR291
CASN292
CASP311
CPRO337
CARG405
CARG436
CTRP516
CPHE517
CPHE525
CGLY529
CPHE530
CASN533
site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE 1PE A 1101
ChainResidue
ALEU153
ATRP314
ALYS316
AARG324
AGLU424
Functional Information from PROSITE/UniProt
site_idPS00505
Number of Residues9
DetailsPEPCK_GTP Phosphoenolpyruvate carboxykinase (GTP) signature. FPSACGKTN
ChainResidueDetails
APHE284-ASN292
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsRegion: {"description":"Omega-loop","evidences":[{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2909519","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31461616","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P5O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine; by p300/EP300","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine; by p300/EP300","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"30193097","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q16822","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q16822","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30193097","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1aq2
ChainResidueDetails
AHIS264
ALYS290
AARG405
site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1aq2
ChainResidueDetails
CHIS264
CLYS290
CARG405
site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1aq2
ChainResidueDetails
AHIS264
AARG405
site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1aq2
ChainResidueDetails
CHIS264
CARG405

246031

PDB entries from 2025-12-10

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