3DSZ
Engineered human lipocalin 2 in complex with Y-DTPA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006915 | biological_process | apoptotic process |
| A | 0015891 | biological_process | siderophore transport |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0035580 | cellular_component | specific granule lumen |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045087 | biological_process | innate immune response |
| A | 0060205 | cellular_component | cytoplasmic vesicle lumen |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| A | 0140315 | molecular_function | iron ion sequestering activity |
| A | 1903981 | molecular_function | enterobactin binding |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006915 | biological_process | apoptotic process |
| B | 0015891 | biological_process | siderophore transport |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0036094 | molecular_function | small molecule binding |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045087 | biological_process | innate immune response |
| B | 0060205 | cellular_component | cytoplasmic vesicle lumen |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| B | 0140315 | molecular_function | iron ion sequestering activity |
| B | 1903981 | molecular_function | enterobactin binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE LIZ A 187 |
| Chain | Residue |
| A | GLN33 |
| A | TYR106 |
| A | PHE123 |
| A | THR136 |
| A | HOH189 |
| A | HOH193 |
| A | HOH197 |
| A | HOH219 |
| A | HOH323 |
| A | HOH334 |
| A | HOH345 |
| A | ARG36 |
| A | THR52 |
| A | GLN54 |
| A | ALA68 |
| A | ARG70 |
| A | ASP77 |
| A | TYR78 |
| A | LEU79 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LIZ B 187 |
| Chain | Residue |
| A | HOH189 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE YT3 B 188 |
| Chain | Residue |
| A | LYS73 |
| A | LYS74 |
| B | GLN33 |
| B | ARG36 |
| B | THR52 |
| B | GLN54 |
| B | ALA68 |
| B | ARG70 |
| B | ASP77 |
| B | LEU79 |
| B | TYR106 |
| B | PHE123 |
| B | THR136 |
| B | HOH223 |
| B | HOH231 |
| B | HOH237 |
| B | HOH263 |
| B | HOH280 |
| B | HOH296 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE YT3 A 188 |
| Chain | Residue |
| B | HOH223 |
Functional Information from PROSITE/UniProt
| site_id | PS00213 |
| Number of Residues | 14 |
| Details | LIPOCALIN Lipocalin signature. NFQdnQFHGKWYQV |
| Chain | Residue | Details |
| A | ASN21-VAL34 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U |
| Chain | Residue | Details |
| B | THR52 | |
| A | THR52 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0007744|PDB:3CMP |
| Chain | Residue | Details |
| A | TYR106 | |
| A | SER134 | |
| B | TYR106 | |
| B | SER134 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15642259, ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U |
| Chain | Residue | Details |
| B | LYS125 | |
| B | LEU138 | |
| A | LYS125 | |
| A | LEU138 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:7683678 |
| Chain | Residue | Details |
| A | GLN1 | |
| B | GLN1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10684642, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7683678, ECO:0007744|PDB:1DFV, ECO:0007744|PDB:1QQS |
| Chain | Residue | Details |
| A | ASN65 | |
| B | ASN65 |
