3DRB
Crystal structure of Human Brain-type Creatine Kinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004111 | molecular_function | creatine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| A | 0021762 | biological_process | substantia nigra development |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0046314 | biological_process | phosphocreatine biosynthetic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140651 | biological_process | futile creatine cycle |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004111 | molecular_function | creatine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| B | 0021762 | biological_process | substantia nigra development |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0046314 | biological_process | phosphocreatine biosynthetic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0140651 | biological_process | futile creatine cycle |
Functional Information from PDB Data
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADP B 400 |
| Chain | Residue |
| B | SER128 |
| B | ARG320 |
| B | GLY323 |
| B | GLY324 |
| B | ASP335 |
| B | ARG130 |
| B | ARG132 |
| B | HIS191 |
| B | ARG236 |
| B | MET240 |
| B | ARG292 |
| B | GLY294 |
| B | HIS296 |
Functional Information from PROSITE/UniProt
| site_id | PS00112 |
| Number of Residues | 7 |
| Details | PHOSPHAGEN_KINASE Phosphagen kinase active site signature. CP.SNLGT |
| Chain | Residue | Details |
| A | CYS283-THR289 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18977227 |
| Chain | Residue | Details |
| A | VAL72 | |
| A | ARG320 | |
| A | ASP335 | |
| B | VAL72 | |
| B | SER128 | |
| B | ARG130 | |
| B | ARG132 | |
| B | HIS191 | |
| B | GLU232 | |
| B | ARG236 | |
| B | SER285 | |
| A | SER128 | |
| B | ARG292 | |
| B | ARG320 | |
| B | ASP335 | |
| A | ARG130 | |
| A | ARG132 | |
| A | HIS191 | |
| A | GLU232 | |
| A | ARG236 | |
| A | SER285 | |
| A | ARG292 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER4 | |
| B | SER4 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR35 | |
| B | THR35 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q04447 |
| Chain | Residue | Details |
| A | TYR125 | |
| B | TYR125 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER199 | |
| B | SER199 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q04447 |
| Chain | Residue | Details |
| A | TYR269 | |
| B | TYR269 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07335 |
| Chain | Residue | Details |
| A | SER309 | |
| B | SER309 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q04447 |
| Chain | Residue | Details |
| A | THR322 | |
| B | THR322 |
