3DOC

Crystal Structure of TrkA glyceraldehyde-3-phosphate dehydrogenase from Brucella melitensis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0000166	molecular_function	nucleotide binding
B	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
C	0000166	molecular_function	nucleotide binding
C	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
D	0000166	molecular_function	nucleotide binding
D	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE NAD A 901

Chain	Residue
A	GLY9
A	ASN316
A	GLU317
A	PHE320
A	PHE10
A	GLY11
A	ARG12
A	ILE13
A	ASP36
A	SER122
A	ALA123
A	CYS153

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NAD B 901

Chain	Residue
B	GLY9
B	GLY11
B	ARG12
B	ILE13
B	ASN35
B	ASP36
B	ARG80
B	CYS98
B	THR99
B	GLY100
B	SER122
B	ALA123
B	CYS153
B	ASN316

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NAD D 901

Chain	Residue
D	GLY9
D	GLY11
D	ARG12
D	ILE13
D	ASN35
D	ASP36
D	LEU37
D	ARG80
D	CYS98
D	THR99
D	GLY100
D	SER122
D	ALA123
D	ASN316

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NAD C 901

Chain	Residue
C	GLY9
C	GLY11
C	ARG12
C	ILE13
C	ASN35
C	ASP36
C	LEU37
C	ARG80
C	CYS98
C	THR99
C	GLY100
C	SER122
C	ALA123
C	CYS153
C	ASN316

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Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
A	ALA151-LEU158

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
A	HIS180
A	CYS153

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
B	HIS180
B	CYS153

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site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
C	HIS180
C	CYS153

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site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
D	HIS180
D	CYS153

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