Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 543 |
| Chain | Residue |
| A | HOH1030 |
| B | ILE136 |
| B | ASN140 |
| B | HOH586 |
| B | HOH844 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 544 |
| Chain | Residue |
| B | SER172 |
| B | PHE176 |
| A | ASP145 |
| A | THR147 |
| A | ARG148 |
| B | LYS137 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 545 |
| Chain | Residue |
| A | ARG148 |
| B | LYS137 |
| B | SER172 |
| B | ALA173 |
| B | HOH782 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 543 |
| Chain | Residue |
| A | PHE500 |
| A | HOH1027 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 544 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 546 |
| Chain | Residue |
| B | ARG82 |
| B | PHE260 |
| B | ALA261 |
| B | GLY288 |
| B | PHE289 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 545 |
| Chain | Residue |
| A | ILE136 |
| A | ASN140 |
| A | PHE176 |
| A | HOH663 |
| A | HOH888 |
| A | HOH1030 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 546 |
| Chain | Residue |
| A | LYS137 |
| A | SER172 |
| A | PHE176 |
| B | ASP145 |
| B | THR147 |
| B | ARG148 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 547 |
| Chain | Residue |
| A | HIS135 |
| A | LEU226 |
| A | HOH845 |
| B | HOH871 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 547 |
| Chain | Residue |
| B | HIS135 |
| B | ASP225 |
| B | LEU226 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 549 |
| Chain | Residue |
| B | PHE150 |
| B | PHE500 |
| B | HOH839 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 548 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 550 |
| Chain | Residue |
| A | GLY170 |
| B | SER164 |
| B | GLU179 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 551 |
| Chain | Residue |
| A | ARG349 |
| A | LEU387 |
| B | LEU423 |
| B | HOH886 |
| B | HOH925 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 552 |
| Chain | Residue |
| A | GLU109 |
| B | TYR21 |
| B | HOH835 |
| B | HOH883 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 549 |
| Chain | Residue |
| A | TYR21 |
| A | ASP238 |
| A | HOH899 |
| B | TYR21 |
| B | GLY22 |
| B | GLU109 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 553 |
| Chain | Residue |
| B | ASN529 |
| B | HOH759 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 554 |
| Chain | Residue |
| B | ASP41 |
| B | GLY42 |
| B | ASP417 |
Functional Information from PROSITE/UniProt
| site_id | PS00721 |
| Number of Residues | 11 |
| Details | FTHFS_1 Formate--tetrahydrofolate ligase signature 1. GLKGGATGGGR |
| Chain | Residue | Details |
| A | GLY91-ARG101 | |
| site_id | PS00722 |
| Number of Residues | 12 |
| Details | FTHFS_2 Formate--tetrahydrofolate ligase signature 2. VATVRALKyHGG |
| Chain | Residue | Details |
| A | VAL316-GLY327 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | THR53 | |
| B | THR53 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1eg7 |
| Chain | Residue | Details |
| A | LYS59 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1eg7 |
| Chain | Residue | Details |
| B | LYS59 | |
