3DLX

Crystal structure of human 3-oxoacid CoA transferase 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006629	biological_process	lipid metabolic process
A	0007507	biological_process	heart development
A	0007584	biological_process	response to nutrient
A	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
A	0008410	molecular_function	CoA-transferase activity
A	0009410	biological_process	response to xenobiotic stimulus
A	0009725	biological_process	response to hormone
A	0014823	biological_process	response to activity
A	0016740	molecular_function	transferase activity
A	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
A	0042594	biological_process	response to starvation
A	0042802	molecular_function	identical protein binding
A	0045471	biological_process	response to ethanol
A	0046952	biological_process	ketone body catabolic process
A	0060612	biological_process	adipose tissue development
A	1902224	biological_process	ketone body metabolic process
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006629	biological_process	lipid metabolic process
B	0007507	biological_process	heart development
B	0007584	biological_process	response to nutrient
B	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
B	0008410	molecular_function	CoA-transferase activity
B	0009410	biological_process	response to xenobiotic stimulus
B	0009725	biological_process	response to hormone
B	0014823	biological_process	response to activity
B	0016740	molecular_function	transferase activity
B	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
B	0042594	biological_process	response to starvation
B	0042802	molecular_function	identical protein binding
B	0045471	biological_process	response to ethanol
B	0046952	biological_process	ketone body catabolic process
B	0060612	biological_process	adipose tissue development
B	1902224	biological_process	ketone body metabolic process
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006629	biological_process	lipid metabolic process
C	0007507	biological_process	heart development
C	0007584	biological_process	response to nutrient
C	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
C	0008410	molecular_function	CoA-transferase activity
C	0009410	biological_process	response to xenobiotic stimulus
C	0009725	biological_process	response to hormone
C	0014823	biological_process	response to activity
C	0016740	molecular_function	transferase activity
C	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
C	0042594	biological_process	response to starvation
C	0042802	molecular_function	identical protein binding
C	0045471	biological_process	response to ethanol
C	0046952	biological_process	ketone body catabolic process
C	0060612	biological_process	adipose tissue development
C	1902224	biological_process	ketone body metabolic process
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006629	biological_process	lipid metabolic process
D	0007507	biological_process	heart development
D	0007584	biological_process	response to nutrient
D	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
D	0008410	molecular_function	CoA-transferase activity
D	0009410	biological_process	response to xenobiotic stimulus
D	0009725	biological_process	response to hormone
D	0014823	biological_process	response to activity
D	0016740	molecular_function	transferase activity
D	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
D	0042594	biological_process	response to starvation
D	0042802	molecular_function	identical protein binding
D	0045471	biological_process	response to ethanol
D	0046952	biological_process	ketone body catabolic process
D	0060612	biological_process	adipose tissue development
D	1902224	biological_process	ketone body metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 1

Chain	Residue
C	PRO158
C	GLY160
C	TYR161
C	MET427
C	THR461
C	GLY462
C	LYS463

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1

Chain	Residue
A	TYR161
A	MET427
A	SER431
A	THR461
A	GLY462
A	LYS463
A	PRO158
A	GLY160

---

Functional Information from PROSITE/UniProt

site_id	PS01273
Number of Residues	16
Details	COA_TRANSF_1 Coenzyme A transferases signature 1. DGatVLVGGFglcGiP

Chain	Residue	Details
A	ASP55-PRO70

---

site_id	PS01274
Number of Residues	9
Details	COA_TRANSF_2 Coenzyme A transferases signature 2. LQSENGVLG

Chain	Residue	Details
A	LEU341-GLY349

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"5-glutamyl coenzyme A thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10034","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9D0K2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---