3DKE

Polar and non-polar cavities in phage T4 lysozyme

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0003796	molecular_function	lysozyme activity
X	0009253	biological_process	peptidoglycan catabolic process
X	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
X	0016998	biological_process	cell wall macromolecule catabolic process
X	0030430	cellular_component	host cell cytoplasm
X	0031640	biological_process	killing of cells of another organism
X	0042742	biological_process	defense response to bacterium
X	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K X 601

Chain	Residue
X	GLU11
X	TYR18
X	HOH906
X	HOH947
X	HOH956
X	HOH1045

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL X 701

Chain	Residue
X	ARG145
X	HOH941
X	HOH1042
X	LYS124
X	THR142
X	ASN144

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL X 702

Chain	Residue
X	ASN132
X	LYS135
X	HOH910

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site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE AZI X 401

Chain	Residue
X	LYS19
X	ARG125
X	TRP126
X	ASP127
X	GLU128
X	HOH924
X	HOH935

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site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE EPE X 901

Chain	Residue
X	ASP47
X	LYS48
X	GLY51
X	ASN53
X	GLY110
X	ALA112
X	GLY113
X	PHE114
X	SER136
X	ARG137
X	TRP138
X	HOH1025
X	HOH1105

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site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BME X 805

Chain	Residue
X	THR34
X	SER36
X	GLU45
X	ASN116
X	HOH1098

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site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BME X 806

Chain	Residue
X	GLN69
X	ASP72
X	ARG96
X	ASN140
X	HOH960
X	HOH1027
X	HOH1121

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site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HED X 801

Chain	Residue
X	ASN81
X	LYS83
X	THR115
X	LEU118
X	HOH1147

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site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HED X 802

Chain	Residue
X	GLU22
X	LYS35
X	GLN105
X	THR109
X	ARG137
X	HOH919
X	HOH985
X	HOH1067
X	HOH1105

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL X 501

Chain	Residue
X	GLY30
X	LEU32
X	ASP70
X	PHE104
X	GLY107
X	HOH1096

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL X 502

Chain	Residue
X	ASN68
X	ASP72
X	ILE100

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
X	GLU11

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
X	ASP20

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
X	LEU32
X	PHE104

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
X	SER117
X	ASN132

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 206l

Chain	Residue	Details
X	GLU11
X	ASP20

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site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
X	GLU11	proton shuttle (general acid/base)
X	ASP20	covalent catalysis

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