3DIN
Crystal structure of the protein-translocation complex formed by the SecY channel and the SecA ATPase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006605 | biological_process | protein targeting |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0008564 | molecular_function | protein-exporting ATPase activity |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0017038 | biological_process | protein import |
| A | 0031522 | cellular_component | cell envelope Sec protein transport complex |
| A | 0043952 | biological_process | protein transport by the Sec complex |
| A | 0065002 | biological_process | intracellular protein transmembrane transport |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006605 | biological_process | protein targeting |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0008564 | molecular_function | protein-exporting ATPase activity |
| B | 0015031 | biological_process | protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0017038 | biological_process | protein import |
| B | 0031522 | cellular_component | cell envelope Sec protein transport complex |
| B | 0043952 | biological_process | protein transport by the Sec complex |
| B | 0065002 | biological_process | intracellular protein transmembrane transport |
| C | 0005048 | molecular_function | signal sequence binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006605 | biological_process | protein targeting |
| C | 0006616 | biological_process | SRP-dependent cotranslational protein targeting to membrane, translocation |
| C | 0008320 | molecular_function | protein transmembrane transporter activity |
| C | 0015031 | biological_process | protein transport |
| C | 0016020 | cellular_component | membrane |
| C | 0031522 | cellular_component | cell envelope Sec protein transport complex |
| C | 0043952 | biological_process | protein transport by the Sec complex |
| C | 0065002 | biological_process | intracellular protein transmembrane transport |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006605 | biological_process | protein targeting |
| D | 0006886 | biological_process | intracellular protein transport |
| D | 0008320 | molecular_function | protein transmembrane transporter activity |
| D | 0009306 | biological_process | protein secretion |
| D | 0015031 | biological_process | protein transport |
| D | 0016020 | cellular_component | membrane |
| D | 0043952 | biological_process | protein transport by the Sec complex |
| D | 0065002 | biological_process | intracellular protein transmembrane transport |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0009306 | biological_process | protein secretion |
| E | 0015031 | biological_process | protein transport |
| E | 0015450 | molecular_function | protein-transporting ATPase activity |
| E | 0016020 | cellular_component | membrane |
| E | 0043952 | biological_process | protein transport by the Sec complex |
| E | 0065002 | biological_process | intracellular protein transmembrane transport |
| F | 0005048 | molecular_function | signal sequence binding |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006605 | biological_process | protein targeting |
| F | 0006616 | biological_process | SRP-dependent cotranslational protein targeting to membrane, translocation |
| F | 0008320 | molecular_function | protein transmembrane transporter activity |
| F | 0015031 | biological_process | protein transport |
| F | 0016020 | cellular_component | membrane |
| F | 0031522 | cellular_component | cell envelope Sec protein transport complex |
| F | 0043952 | biological_process | protein transport by the Sec complex |
| F | 0065002 | biological_process | intracellular protein transmembrane transport |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006605 | biological_process | protein targeting |
| G | 0006886 | biological_process | intracellular protein transport |
| G | 0008320 | molecular_function | protein transmembrane transporter activity |
| G | 0009306 | biological_process | protein secretion |
| G | 0015031 | biological_process | protein transport |
| G | 0016020 | cellular_component | membrane |
| G | 0043952 | biological_process | protein transport by the Sec complex |
| G | 0065002 | biological_process | intracellular protein transmembrane transport |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0009306 | biological_process | protein secretion |
| H | 0015031 | biological_process | protein transport |
| H | 0015450 | molecular_function | protein-transporting ATPase activity |
| H | 0016020 | cellular_component | membrane |
| H | 0043952 | biological_process | protein transport by the Sec complex |
| H | 0065002 | biological_process | intracellular protein transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 872 |
| Chain | Residue |
| A | LYS101 |
| A | THR102 |
| A | ARG131 |
| A | ASP252 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 872 |
| Chain | Residue |
| B | LYS101 |
| B | THR102 |
| B | ARG131 |
| B | ASP252 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP A 873 |
| Chain | Residue |
| A | ARG75 |
| A | PRO76 |
| A | LYS96 |
| A | THR97 |
| A | GLY98 |
| A | GLY100 |
| A | LYS101 |
| A | THR102 |
| A | LEU103 |
| A | TRP135 |
| A | LEU187 |
| A | ASP537 |
| A | ARG573 |
| A | GLN574 |
| A | MET74 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BEF A 874 |
| Chain | Residue |
| A | LYS101 |
| A | ARG131 |
| A | ASP252 |
| A | GLU253 |
| A | GLY535 |
| A | THR536 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP B 873 |
| Chain | Residue |
| B | MET74 |
| B | ARG75 |
| B | PRO76 |
| B | LYS96 |
| B | THR97 |
| B | GLY98 |
| B | GLY100 |
| B | LYS101 |
| B | THR102 |
| B | LEU103 |
| B | TRP135 |
| B | LEU187 |
| B | ASP537 |
| B | ARG573 |
| B | GLN574 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BEF B 874 |
| Chain | Residue |
| B | LYS101 |
| B | ARG131 |
| B | ASP252 |
| B | GLU253 |
| B | GLY535 |
| B | THR536 |
Functional Information from PROSITE/UniProt
| site_id | PS00755 |
| Number of Residues | 20 |
| Details | SECY_1 Protein secY signature 1. SVFtMSVtPYItASIILQLL |
| Chain | Residue | Details |
| C | SER76-LEU95 |
| site_id | PS00756 |
| Number of Residues | 18 |
| Details | SECY_2 Protein secY signature 2. WLgErITek.GIGNGiSIL |
| Chain | Residue | Details |
| C | TRP173-LEU190 |
| site_id | PS01067 |
| Number of Residues | 29 |
| Details | SECE_SEC61G Protein secE/sec61-gamma signature. FfREvIaeAkKisWPsrkElltsfGVVLV |
| Chain | Residue | Details |
| D | PHE7-VAL35 |
| site_id | PS01312 |
| Number of Residues | 16 |
| Details | SECA SecA family signature. VtIATNMAGRGtDIkL |
| Chain | Residue | Details |
| A | VAL525-LEU540 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 66 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| D | MET1-LEU34 | |
| F | ILE227-VAL270 | |
| F | PHE316-ALA367 | |
| F | ASP404-ARG431 | |
| G | MET1-LEU34 | |
| C | THR179-GLY182 | |
| C | ILE227-VAL270 | |
| C | PHE316-ALA367 | |
| C | ASP404-ARG431 | |
| F | MET1-ARG17 | |
| F | ALA96-THR120 | |
| F | THR179-GLY182 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| D | VAL35-PHE51 | |
| G | VAL35-PHE51 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 26 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| D | SER52-GLY65 | |
| F | ALA383-TRP389 | |
| G | SER52-GLY65 | |
| C | TYR199-LEU213 | |
| C | SER284-GLY302 | |
| C | ALA383-TRP389 | |
| F | TYR33-SER73 | |
| F | PHE134-THR161 | |
| F | TYR199-LEU213 | |
| F | SER284-GLY302 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | TRANSMEM: Discontinuously helical; Name=Helix 2 |
| Chain | Residue | Details |
| C | ARG74-LEU95 | |
| F | ARG74-LEU95 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | INTRAMEM: Helical; Name=Helix 2A |
| Chain | Residue | Details |
| C | ARG74-VAL77 | |
| F | ARG74-VAL77 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| C | PHE78-PRO84 | |
| F | PHE78-PRO84 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | INTRAMEM: Helical; Name=Helix 2B |
| Chain | Residue | Details |
| C | TYR85-LEU95 | |
| F | TYR85-LEU95 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=Helix 3 |
| Chain | Residue | Details |
| C | ARG121-PHE133 | |
| F | ARG121-PHE133 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=Helix 4 |
| Chain | Residue | Details |
| C | MET162-ILE178 | |
| F | MET162-ILE178 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=Helix 5 |
| Chain | Residue | Details |
| C | ILE183-ARG198 | |
| F | ILE183-ARG198 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=Helix 6 |
| Chain | Residue | Details |
| C | LEU214-THR226 | |
| F | LEU214-THR226 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=Helix 7 |
| Chain | Residue | Details |
| C | ILE271-PRO283 | |
| F | ILE271-PRO283 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=Helix 8 |
| Chain | Residue | Details |
| C | GLY303-PHE315 | |
| F | GLY303-PHE315 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=Helix 9 |
| Chain | Residue | Details |
| C | VAL368-GLY382 | |
| F | VAL368-GLY382 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=Helix 10 |
| Chain | Residue | Details |
| C | ILE390-LEU403 | |
| F | ILE390-LEU403 |
