3DIN
Crystal structure of the protein-translocation complex formed by the SecY channel and the SecA ATPase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006605 | biological_process | protein targeting |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0008564 | molecular_function | protein-exporting ATPase activity |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0017038 | biological_process | protein import |
| A | 0031522 | cellular_component | cell envelope Sec protein transport complex |
| A | 0043952 | biological_process | protein transport by the Sec complex |
| A | 0065002 | biological_process | intracellular protein transmembrane transport |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006605 | biological_process | protein targeting |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0008564 | molecular_function | protein-exporting ATPase activity |
| B | 0015031 | biological_process | protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0017038 | biological_process | protein import |
| B | 0031522 | cellular_component | cell envelope Sec protein transport complex |
| B | 0043952 | biological_process | protein transport by the Sec complex |
| B | 0065002 | biological_process | intracellular protein transmembrane transport |
| C | 0005048 | molecular_function | signal sequence binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006605 | biological_process | protein targeting |
| C | 0006616 | biological_process | SRP-dependent cotranslational protein targeting to membrane, translocation |
| C | 0008320 | molecular_function | protein transmembrane transporter activity |
| C | 0015031 | biological_process | protein transport |
| C | 0016020 | cellular_component | membrane |
| C | 0031522 | cellular_component | cell envelope Sec protein transport complex |
| C | 0043952 | biological_process | protein transport by the Sec complex |
| C | 0065002 | biological_process | intracellular protein transmembrane transport |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006605 | biological_process | protein targeting |
| D | 0006886 | biological_process | intracellular protein transport |
| D | 0008320 | molecular_function | protein transmembrane transporter activity |
| D | 0009306 | biological_process | protein secretion |
| D | 0015031 | biological_process | protein transport |
| D | 0016020 | cellular_component | membrane |
| D | 0043952 | biological_process | protein transport by the Sec complex |
| D | 0065002 | biological_process | intracellular protein transmembrane transport |
| E | 0009306 | biological_process | protein secretion |
| E | 0015450 | molecular_function | protein-transporting ATPase activity |
| E | 0016020 | cellular_component | membrane |
| F | 0005048 | molecular_function | signal sequence binding |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006605 | biological_process | protein targeting |
| F | 0006616 | biological_process | SRP-dependent cotranslational protein targeting to membrane, translocation |
| F | 0008320 | molecular_function | protein transmembrane transporter activity |
| F | 0015031 | biological_process | protein transport |
| F | 0016020 | cellular_component | membrane |
| F | 0031522 | cellular_component | cell envelope Sec protein transport complex |
| F | 0043952 | biological_process | protein transport by the Sec complex |
| F | 0065002 | biological_process | intracellular protein transmembrane transport |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006605 | biological_process | protein targeting |
| G | 0006886 | biological_process | intracellular protein transport |
| G | 0008320 | molecular_function | protein transmembrane transporter activity |
| G | 0009306 | biological_process | protein secretion |
| G | 0015031 | biological_process | protein transport |
| G | 0016020 | cellular_component | membrane |
| G | 0043952 | biological_process | protein transport by the Sec complex |
| G | 0065002 | biological_process | intracellular protein transmembrane transport |
| H | 0009306 | biological_process | protein secretion |
| H | 0015450 | molecular_function | protein-transporting ATPase activity |
| H | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 872 |
| Chain | Residue |
| A | LYS101 |
| A | THR102 |
| A | ARG131 |
| A | ASP252 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 872 |
| Chain | Residue |
| B | LYS101 |
| B | THR102 |
| B | ARG131 |
| B | ASP252 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP A 873 |
| Chain | Residue |
| A | ARG75 |
| A | PRO76 |
| A | LYS96 |
| A | THR97 |
| A | GLY98 |
| A | GLY100 |
| A | LYS101 |
| A | THR102 |
| A | LEU103 |
| A | TRP135 |
| A | LEU187 |
| A | ASP537 |
| A | ARG573 |
| A | GLN574 |
| A | MET74 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BEF A 874 |
| Chain | Residue |
| A | LYS101 |
| A | ARG131 |
| A | ASP252 |
| A | GLU253 |
| A | GLY535 |
| A | THR536 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP B 873 |
| Chain | Residue |
| B | MET74 |
| B | ARG75 |
| B | PRO76 |
| B | LYS96 |
| B | THR97 |
| B | GLY98 |
| B | GLY100 |
| B | LYS101 |
| B | THR102 |
| B | LEU103 |
| B | TRP135 |
| B | LEU187 |
| B | ASP537 |
| B | ARG573 |
| B | GLN574 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BEF B 874 |
| Chain | Residue |
| B | LYS101 |
| B | ARG131 |
| B | ASP252 |
| B | GLU253 |
| B | GLY535 |
| B | THR536 |
Functional Information from PROSITE/UniProt
| site_id | PS00755 |
| Number of Residues | 20 |
| Details | SECY_1 Protein secY signature 1. SVFtMSVtPYItASIILQLL |
| Chain | Residue | Details |
| C | SER76-LEU95 |
| site_id | PS00756 |
| Number of Residues | 18 |
| Details | SECY_2 Protein secY signature 2. WLgErITek.GIGNGiSIL |
| Chain | Residue | Details |
| C | TRP173-LEU190 |
| site_id | PS01067 |
| Number of Residues | 29 |
| Details | SECE_SEC61G Protein secE/sec61-gamma signature. FfREvIaeAkKisWPsrkElltsfGVVLV |
| Chain | Residue | Details |
| D | PHE7-VAL35 |
| site_id | PS01312 |
| Number of Residues | 16 |
| Details | SECA SecA family signature. VtIATNMAGRGtDIkL |
| Chain | Residue | Details |
| A | VAL525-LEU540 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01382","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Discontinuously helical; Name=Helix 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Intramembrane: {"description":"Helical; Name=Helix 2A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Intramembrane: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Intramembrane: {"description":"Helical; Name=Helix 2B"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 242 |
| Details | Topological domain: {"description":"Cytoplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 130 |
| Details | Topological domain: {"description":"Periplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 26 |
| Details | Topological domain: {"description":"Extracellular"} |
| Chain | Residue | Details |
