3DHH
Crystal Structure of Resting State Toluene 4-Monoxygenase Hydroxylase Complexed with Effector Protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0018638 | molecular_function | toluene 4-monooxygenase activity |
| A | 0042203 | biological_process | toluene catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| B | 0018638 | molecular_function | toluene 4-monooxygenase activity |
| B | 0042203 | biological_process | toluene catabolic process |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0018638 | molecular_function | toluene 4-monooxygenase activity |
| C | 0042203 | biological_process | toluene catabolic process |
| E | 0004497 | molecular_function | monooxygenase activity |
| E | 0042203 | biological_process | toluene catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FE A 501 |
| Chain | Residue |
| A | GLU104 |
| A | GLU134 |
| A | HIS137 |
| A | FE502 |
| A | 1PE505 |
| A | HOH512 |
| A | HOH515 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FE A 502 |
| Chain | Residue |
| A | GLU231 |
| A | HIS234 |
| A | FE501 |
| A | 1PE505 |
| A | HOH512 |
| A | GLU134 |
| A | GLU197 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BML A 503 |
| Chain | Residue |
| A | TRP167 |
| A | GLY334 |
| A | VAL335 |
| A | TRP338 |
| A | THR341 |
| A | PRO403 |
| A | VAL405 |
| A | BML507 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BML A 504 |
| Chain | Residue |
| A | TRP338 |
| A | GLU391 |
| A | THR392 |
| A | LEU393 |
| A | THR463 |
| A | LEU464 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1PE A 505 |
| Chain | Residue |
| A | ALA99 |
| A | ILE100 |
| A | GLY103 |
| A | GLU104 |
| A | GLU134 |
| A | TYR162 |
| A | PHE176 |
| A | GLU197 |
| A | FE501 |
| A | FE502 |
| A | HOH512 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BML A 507 |
| Chain | Residue |
| A | TRP167 |
| A | LEU393 |
| A | PRO394 |
| A | VAL396 |
| A | GLN401 |
| A | ILE402 |
| A | PRO403 |
| A | ILE450 |
| A | BML503 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BTB A 509 |
| Chain | Residue |
| A | GLU214 |
| A | SER287 |
| A | HOH837 |
| A | HOH860 |
| E | ASP44 |
| E | ARG45 |
| E | ARG46 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BML B 508 |
| Chain | Residue |
| A | MET3 |
| A | PRO56 |
| B | GLU91 |
| B | GLN95 |
| B | PHE98 |
| B | THR164 |
| B | HIS165 |
| B | TYR168 |
| B | HOH346 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BML E 507 |
| Chain | Residue |
| A | ARG6 |
| A | TYR51 |
| E | MET74 |
| E | GLN75 |
| E | ALA90 |
| E | ILE95 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19033467, ECO:0000269|PubMed:19290655, ECO:0000269|PubMed:19705873, ECO:0000269|PubMed:22264099, ECO:0000269|PubMed:25248368, ECO:0000269|PubMed:28346937, ECO:0007744|PDB:3Q14, ECO:0007744|PDB:3Q2A, ECO:0007744|PDB:3Q3M, ECO:0007744|PDB:3Q3N, ECO:0007744|PDB:3Q3O, ECO:0007744|PDB:3RI7, ECO:0007744|PDB:3RMK, ECO:0007744|PDB:4P1B, ECO:0007744|PDB:4P1C, ECO:0007744|PDB:5TDS, ECO:0007744|PDB:5TDT, ECO:0007744|PDB:5TDU, ECO:0007744|PDB:5TDV |
| Chain | Residue | Details |
| A | GLU104 | |
| A | GLU134 | |
| A | HIS137 | |
| A | GLU197 | |
| A | GLU231 | |
| A | HIS234 |
