Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000305 | biological_process | response to oxygen radical |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0007507 | biological_process | heart development |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0030097 | biological_process | hemopoiesis |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD A 500 |
| Chain | Residue |
| A | GLY13 |
| A | CYS53 |
| A | VAL56 |
| A | GLY57 |
| A | CYS58 |
| A | LYS61 |
| A | ILE124 |
| A | ALA126 |
| A | ALA154 |
| A | THR155 |
| A | GLY156 |
| A | GLY15 |
| A | TYR195 |
| A | ARG285 |
| A | LEU292 |
| A | GLY325 |
| A | ASP326 |
| A | GLU333 |
| A | LEU334 |
| A | THR335 |
| A | PRO336 |
| A | HIS464 |
| A | SER16 |
| A | HOH511 |
| A | HOH513 |
| A | HOH515 |
| A | HOH611 |
| A | GLY17 |
| A | ALA35 |
| A | ASP36 |
| A | TYR37 |
| A | GLY51 |
| A | THR52 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE NA7 A 501 |
| Chain | Residue |
| A | ARG160 |
| A | GLY192 |
| A | ALA193 |
| A | SER194 |
| A | ARG216 |
| A | SER217 |
| A | ARG221 |
| A | ALA282 |
| A | ILE283 |
| A | GLY284 |
| A | ARG285 |
| A | GLU333 |
| A | HOH551 |
| A | HOH582 |
| A | HOH654 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
| Chain | Residue | Details |
| A | GLY50-PRO60 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS58 | |
| A | CYS53 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | GLU469 | |
| A | HIS464 | |
