Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD A 500 |
| Chain | Residue |
| A | GLY16 |
| A | VAL60 |
| A | GLY61 |
| A | CYS62 |
| A | LYS65 |
| A | GLY128 |
| A | LEU129 |
| A | GLY130 |
| A | ALA157 |
| A | VAL158 |
| A | GLY159 |
| A | GLY18 |
| A | TYR197 |
| A | ARG287 |
| A | LEU290 |
| A | LEU294 |
| A | GLY325 |
| A | ASP326 |
| A | GLU333 |
| A | LEU334 |
| A | THR335 |
| A | PRO336 |
| A | SER19 |
| A | HOH601 |
| A | HOH621 |
| A | HOH626 |
| A | HOH628 |
| A | HOH669 |
| A | HOH769 |
| B | HIS464 |
| A | ALA20 |
| A | ASP39 |
| A | PHE40 |
| A | GLY55 |
| A | THR56 |
| A | CYS57 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | HIS464 |
| A | ARG473 |
| A | HOH698 |
| A | HOH773 |
| A | HOH825 |
| A | HOH924 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 503 |
| Chain | Residue |
| A | GLY169 |
| A | ALA170 |
| A | VAL171 |
| A | GLU172 |
| site_id | AC4 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD B 500 |
| Chain | Residue |
| A | HIS464 |
| B | GLY16 |
| B | GLY17 |
| B | GLY18 |
| B | SER19 |
| B | ALA20 |
| B | ASP39 |
| B | PHE40 |
| B | GLY55 |
| B | THR56 |
| B | CYS57 |
| B | VAL60 |
| B | GLY61 |
| B | CYS62 |
| B | LYS65 |
| B | GLY128 |
| B | LEU129 |
| B | GLY130 |
| B | VAL158 |
| B | GLY159 |
| B | TYR197 |
| B | ARG287 |
| B | LEU290 |
| B | GLY325 |
| B | ASP326 |
| B | GLU333 |
| B | LEU334 |
| B | THR335 |
| B | PRO336 |
| B | HOH667 |
| B | HOH670 |
| B | HOH727 |
| B | HOH815 |
| B | HOH905 |
| B | HOH1003 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 502 |
| Chain | Residue |
| B | HIS464 |
| B | ARG473 |
| B | HOH637 |
| B | HOH707 |
| B | HOH735 |
| B | HOH858 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 504 |
| Chain | Residue |
| B | GLY169 |
| B | ALA170 |
| B | VAL171 |
| B | GLU172 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
| Chain | Residue | Details |
| A | GLY54-PRO64 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17385893","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 108 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17385893","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS62 | |
| A | CYS57 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| B | CYS62 | |
| B | CYS57 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | GLU469 | |
| A | HIS464 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| B | GLU469 | |
| B | HIS464 | |
