3DC2
Crystal structure of serine bound D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004617 | molecular_function | phosphoglycerate dehydrogenase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0006564 | biological_process | L-serine biosynthetic process |
A | 0009274 | cellular_component | peptidoglycan-based cell wall |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0051287 | molecular_function | NAD binding |
B | 0004617 | molecular_function | phosphoglycerate dehydrogenase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0006564 | biological_process | L-serine biosynthetic process |
B | 0009274 | cellular_component | peptidoglycan-based cell wall |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SER A 600 |
Chain | Residue |
A | TYR461 |
B | ILE482 |
A | ASP463 |
A | ARG464 |
A | PRO465 |
A | GLY466 |
A | ALA467 |
A | LEU468 |
A | LEU487 |
B | ASN481 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SER B 600 |
Chain | Residue |
A | ASN481 |
A | ILE482 |
B | TYR461 |
B | ASP463 |
B | ARG464 |
B | GLY466 |
B | LEU468 |
B | LEU487 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE TLA A 700 |
Chain | Residue |
A | ARG446 |
A | HIS447 |
A | HOH817 |
B | LYS439 |
B | ASP449 |
B | LEU450 |
B | ARG451 |
B | ARG501 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE TLA B 700 |
Chain | Residue |
A | LYS439 |
A | ASP449 |
A | LEU450 |
A | ARG451 |
A | ALA484 |
A | ARG501 |
B | ARG446 |
B | HIS447 |
B | SER488 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE TLA B 701 |
Chain | Residue |
B | GLU361 |
B | GLU363 |
B | LYS402 |
Functional Information from PROSITE/UniProt
site_id | PS00065 |
Number of Residues | 28 |
Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. VGVVGlGRIGqlvaqriaafgay.VVaYD |
Chain | Residue | Details |
A | VAL145-ASP172 |
site_id | PS00670 |
Number of Residues | 23 |
Details | D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. LLarADFIsVHlPktpeTagLiD |
Chain | Residue | Details |
A | LEU193-ASP215 |
site_id | PS00671 |
Number of Residues | 17 |
Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. TKpGvIIVNaARGgLVD |
Chain | Residue | Details |
A | THR222-ASP238 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: ACT_SITE => ECO:0000250 |
Chain | Residue | Details |
A | ARG233 | |
A | GLU262 | |
B | ARG233 | |
B | GLU262 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000250 |
Chain | Residue | Details |
A | HIS280 | |
B | HIS280 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A9T0 |
Chain | Residue | Details |
A | ARG152 | |
B | HIS280 | |
A | ASP172 | |
A | ALA231 | |
A | ASP257 | |
A | HIS280 | |
B | ARG152 | |
B | ASP172 | |
B | ALA231 | |
B | ASP257 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1gdh |
Chain | Residue | Details |
A | HIS280 | |
A | ASP257 | |
A | GLU262 | |
A | ARG233 | |
A | GLY235 |
site_id | CSA2 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1gdh |
Chain | Residue | Details |
B | HIS280 | |
B | ASP257 | |
B | GLU262 | |
B | ARG233 | |
B | GLY235 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1gdh |
Chain | Residue | Details |
A | HIS280 | |
A | GLU262 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1gdh |
Chain | Residue | Details |
B | HIS280 | |
B | GLU262 |