3DAP
C. GLUTAMICUM DAP DEHYDROGENASE IN COMPLEX WITH NADP+ AND THE INHIBITOR 5S-ISOXAZOLINE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0047850 | molecular_function | diaminopimelate dehydrogenase activity |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019877 | biological_process | diaminopimelate biosynthetic process |
| B | 0047850 | molecular_function | diaminopimelate dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NDP A 401 |
| Chain | Residue |
| A | GLY10 |
| A | TYR11 |
| A | GLY12 |
| A | ASN13 |
| A | LEU14 |
| A | SER35 |
| A | ARG36 |
| A | ARG37 |
| A | CYS65 |
| A | MET66 |
| A | GLY67 |
| A | SER68 |
| A | THR88 |
| A | ASP90 |
| A | THR117 |
| A | GLY118 |
| A | TRP119 |
| A | ASP120 |
| A | PRO121 |
| A | ASN270 |
| A | THR274 |
| A | HOH1001 |
| A | HOH1002 |
| A | HOH1021 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NDP B 901 |
| Chain | Residue |
| B | GLY10 |
| B | TYR11 |
| B | GLY12 |
| B | ASN13 |
| B | LEU14 |
| B | SER35 |
| B | ARG36 |
| B | ARG37 |
| B | CYS65 |
| B | MET66 |
| B | GLY67 |
| B | SER68 |
| B | THR88 |
| B | ASP90 |
| B | THR117 |
| B | GLY118 |
| B | TRP119 |
| B | ASP120 |
| B | PRO121 |
| B | GLN150 |
| B | GLY151 |
| B | ARG157 |
| B | ASN270 |
| B | THR274 |
| B | DA3950 |
| B | HOH1055 |
| B | HOH1056 |
| B | HOH1057 |
| B | HOH1058 |
| B | HOH1059 |
| B | HOH1061 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE DA3 B 950 |
| Chain | Residue |
| B | ASP120 |
| B | TRP144 |
| B | SER149 |
| B | GLN150 |
| B | GLY151 |
| B | THR169 |
| B | ARG195 |
| B | HIS244 |
| B | ASN270 |
| B | NDP901 |
| B | ASP90 |
| B | TRP119 |
| site_id | INH |
| Number of Residues | 9 |
| Details | INHIBITOR BINDING SITE IN SECOND MOLECULE. |
| Chain | Residue |
| B | ASP90 |
| B | HIS92 |
| B | ASP120 |
| B | GLN150 |
| B | GLY151 |
| B | THR169 |
| B | ARG195 |
| B | HIS244 |
| B | ASN270 |
| site_id | N1 |
| Number of Residues | 15 |
| Details | NADP+ BINDING SITE IN FIRST MOLECULE. |
| Chain | Residue |
| A | GLY10 |
| A | SER68 |
| A | ASP90 |
| A | THR117 |
| A | GLY118 |
| A | TRP119 |
| A | ASP120 |
| A | TYR11 |
| A | GLY12 |
| A | ASN13 |
| A | GLY15 |
| A | SER35 |
| A | ARG36 |
| A | ARG37 |
| A | CYS65 |
| site_id | N2 |
| Number of Residues | 18 |
| Details | NADP+ BINDING SITE IN SECOND MOLECULE. |
| Chain | Residue |
| B | GLY10 |
| B | TYR11 |
| B | GLY12 |
| B | ASN13 |
| B | LEU14 |
| B | GLY15 |
| B | SER35 |
| B | ARG36 |
| B | ARG37 |
| B | CYS65 |
| B | SER68 |
| B | ASP90 |
| B | THR117 |
| B | GLY118 |
| B | TRP119 |
| B | ASP120 |
| B | GLN150 |
| B | ARG157 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 26 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | TYR11 | |
| A | THR169 | |
| A | ARG195 | |
| A | HIS244 | |
| A | ASN270 | |
| B | TYR11 | |
| B | SER35 | |
| B | CYS65 | |
| B | THR88 | |
| B | ASP90 | |
| B | THR117 | |
| A | SER35 | |
| B | ASP120 | |
| B | TRP144 | |
| B | GLN150 | |
| B | THR169 | |
| B | ARG195 | |
| B | HIS244 | |
| B | ASN270 | |
| A | CYS65 | |
| A | THR88 | |
| A | ASP90 | |
| A | THR117 | |
| A | ASP120 | |
| A | TRP144 | |
| A | GLN150 |
