3DAK

Crystal Structure of Domain-Swapped OSR1 kinase domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ANP C 1

Chain	Residue
A	LYS234
C	LEU153
C	ASP164
C	MG296
C	HOH302
C	HOH348
C	HOH461
C	HOH537
C	ILE23
C	VAL31
C	LYS46
C	MET92
C	LYS93
C	LEU95
C	ASP146
C	ASN151

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ANP B 1

Chain	Residue
B	ILE23
B	VAL31
B	LYS46
B	VAL76
B	MET92
B	LYS93
B	LEU95
B	LYS148
B	ASN151
B	LEU153
B	ASP164
B	MG296
B	HOH351
B	HOH558
B	HOH668

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ANP D 1

Chain	Residue
B	LYS234
D	ILE23
D	VAL31
D	LYS46
D	MET92
D	LYS93
D	LEU95
D	LEU153
D	ASP164
D	MG296
D	HOH307
D	HOH627
D	HOH646
D	HOH649

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ANP A 1

Chain	Residue
A	ILE23
A	GLY24
A	SER25
A	VAL31
A	LYS46
A	VAL76
A	LYS93
A	LEU95
A	ASP146
A	ASN151
A	ASP164
A	MG296
A	HOH300
A	HOH349
A	HOH370
A	HOH378
A	HOH630
A	HOH633
A	HOH656

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 296

Chain	Residue
A	ANP1
A	GLY150
A	ASN151

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 296

Chain	Residue
B	ANP1
B	GLY150
B	ASN151

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 296

Chain	Residue
C	ANP1
C	GLY150
C	ASN151

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 296

Chain	Residue
D	ANP1
D	ASN151
D	ASP164

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGATAVVQaAycapkkek..........VAIK

Chain	Residue	Details
A	ILE23-LYS46

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q9Z1W9","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Z1W9","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14707132","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by WNK1","evidences":[{"source":"PubMed","id":"16669787","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16832045","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17190791","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21321328","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23386621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29581290","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP146
A	GLY150

---

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	THR189
B	LYS148
B	ASP146

---

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	THR189
C	LYS148
C	ASP146

---

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	THR189
D	LYS148
D	ASP146

---

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASN151
A	LYS148
A	ASP146

---

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASN151
B	LYS148
B	ASP146

---

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASN151
C	LYS148
C	ASP146

---

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASN151
D	LYS148
D	ASP146

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP146
B	GLY150

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP146
C	GLY150

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP146
D	GLY150

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS148
A	ASP146

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	LYS148
B	ASP146

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	LYS148
C	ASP146

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	LYS148
D	ASP146

---

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR189
A	LYS148
A	ASP146

---