3DAB
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| C | 0005634 | cellular_component | nucleus |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0051726 | biological_process | regulation of cell cycle |
| E | 0005634 | cellular_component | nucleus |
| E | 0043066 | biological_process | negative regulation of apoptotic process |
| E | 0051726 | biological_process | regulation of cell cycle |
| G | 0005634 | cellular_component | nucleus |
| G | 0043066 | biological_process | negative regulation of apoptotic process |
| G | 0051726 | biological_process | regulation of cell cycle |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17967874, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:28842590 |
| Chain | Residue | Details |
| B | SER15 | |
| D | SER15 | |
| F | SER15 | |
| H | SER15 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by CK1, VRK1 and VRK2 => ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:16704422 |
| Chain | Residue | Details |
| B | THR18 | |
| D | THR18 | |
| F | THR18 | |
| H | THR18 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CHEK2, CK1 and PLK3 => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:20041275 |
| Chain | Residue | Details |
| B | SER20 | |
| D | SER20 | |
| F | SER20 | |
| H | SER20 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21597459 |
| Chain | Residue | Details |
| B | LYS24 | |
| D | LYS24 | |
| F | LYS24 | |
| H | LYS24 |
