3DA8

Crystal structure of PurN from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0016740	molecular_function	transferase activity
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006189	biological_process	'de novo' IMP biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0016740	molecular_function	transferase activity
B	0046653	biological_process	tetrahydrofolate metabolic process
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 601

Chain	Residue
A	ASN116
A	THR117
A	HOH618
A	HOH664
A	HOH677
A	HOH711

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 603

Chain	Residue
A	LEU26

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 606

Chain	Residue
A	GLU177

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 609

Chain	Residue
A	HOH739
B	PHE125
B	HOH759
A	GLY215

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 611

Chain	Residue
A	HOH814

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BME A 612

Chain	Residue
A	ALA124
A	PHE125
A	VAL141
A	HOH625
A	HOH629
B	LEU121
B	LEU122
B	ALA124

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 610

Chain	Residue
B	ARG51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01930

Chain	Residue	Details
A	HIS118
B	HIS118

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01930

Chain	Residue	Details
A	ARG74
B	ARG74

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
A	ARG100
A	ASN116
A	THR117
A	ASP150
B	ARG100
B	ASN116
B	THR117
B	ASP150

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Raises pKa of active site His => ECO:0000255|HAMAP-Rule:MF_01930

Chain	Residue	Details
A	ASP154
B	ASP154

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
A	HIS118
A	THR145
A	ASP154
A	ASN116

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
B	HIS118
B	THR145
B	ASP154
B	ASN116

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
A	HIS118
A	ASP154
A	ASN116

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
B	HIS118
B	ASP154
B	ASN116

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
A	HIS118
A	ASP154

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
B	HIS118
B	ASP154

---