Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0005829 | cellular_component | cytosol |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0005829 | cellular_component | cytosol |
| B | 0008198 | molecular_function | ferrous iron binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE FAD A 1001 |
| Chain | Residue |
| A | ILE9 |
| A | ALA37 |
| A | ILE40 |
| A | ALA41 |
| A | GLY44 |
| A | GLN45 |
| A | LEU46 |
| A | ILE52 |
| A | ASN54 |
| A | THR86 |
| A | THR119 |
| A | GLY10 |
| A | GLY120 |
| A | TRP135 |
| A | CYS145 |
| A | GLY287 |
| A | ASP288 |
| A | ARG295 |
| A | GLN296 |
| A | ALA297 |
| A | SER300 |
| B | TYR21 |
| A | SER11 |
| A | GLY12 |
| A | PRO13 |
| A | ALA14 |
| A | TYR32 |
| A | GLU33 |
| A | GLY34 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE FAD B 1001 |
| Chain | Residue |
| A | TYR21 |
| B | ILE9 |
| B | GLY10 |
| B | SER11 |
| B | GLY12 |
| B | PRO13 |
| B | ALA14 |
| B | TYR32 |
| B | GLU33 |
| B | GLY34 |
| B | ALA37 |
| B | ILE40 |
| B | ALA41 |
| B | GLY44 |
| B | GLN45 |
| B | LEU46 |
| B | THR49 |
| B | ILE52 |
| B | ASN54 |
| B | THR119 |
| B | GLY120 |
| B | TRP135 |
| B | CYS145 |
| B | GLY287 |
| B | ASP288 |
| B | ARG295 |
| B | GLN296 |
| B | ALA297 |
| B | SER300 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NDP A 481 |
| Chain | Residue |
| A | MET126 |
| A | GLY161 |
| A | GLY163 |
| A | SER165 |
| A | ARG185 |
| A | LYS186 |
| A | ARG190 |
| A | ILE248 |
| B | ASP106 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 23 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CavCDGavpiFrnkpLaVIGGGD |
| Chain | Residue | Details |
| A | CYS142-ASP164 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18930846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20235561","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1tde |
| Chain | Residue | Details |
| A | CYS142 | |
| A | CYS145 | |
| A | ASP146 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1tde |
| Chain | Residue | Details |
| B | CYS142 | |
| B | CYS145 | |
| B | ASP146 | |
