3D5O

Structural recognition and functional activation of FcrR by innate pentraxins

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001849	molecular_function	complement component C1q complex binding
A	0002674	biological_process	negative regulation of acute inflammatory response
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0006457	biological_process	protein folding
A	0006953	biological_process	acute-phase response
A	0030246	molecular_function	carbohydrate binding
A	0042802	molecular_function	identical protein binding
A	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
A	0045087	biological_process	innate immune response
A	0045656	biological_process	negative regulation of monocyte differentiation
A	0046597	biological_process	host-mediated suppression of symbiont invasion
A	0046790	molecular_function	virion binding
A	0046872	molecular_function	metal ion binding
A	0048525	biological_process	negative regulation of viral process
A	0051082	molecular_function	unfolded protein binding
A	0051131	biological_process	chaperone-mediated protein complex assembly
A	0061045	biological_process	negative regulation of wound healing
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
A	1903019	biological_process	negative regulation of glycoprotein metabolic process
B	0001849	molecular_function	complement component C1q complex binding
B	0002674	biological_process	negative regulation of acute inflammatory response
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0006457	biological_process	protein folding
B	0006953	biological_process	acute-phase response
B	0030246	molecular_function	carbohydrate binding
B	0042802	molecular_function	identical protein binding
B	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
B	0045087	biological_process	innate immune response
B	0045656	biological_process	negative regulation of monocyte differentiation
B	0046597	biological_process	host-mediated suppression of symbiont invasion
B	0046790	molecular_function	virion binding
B	0046872	molecular_function	metal ion binding
B	0048525	biological_process	negative regulation of viral process
B	0051082	molecular_function	unfolded protein binding
B	0051131	biological_process	chaperone-mediated protein complex assembly
B	0061045	biological_process	negative regulation of wound healing
B	0070062	cellular_component	extracellular exosome
B	0072562	cellular_component	blood microparticle
B	1903019	biological_process	negative regulation of glycoprotein metabolic process
C	0001849	molecular_function	complement component C1q complex binding
C	0002674	biological_process	negative regulation of acute inflammatory response
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0006457	biological_process	protein folding
C	0006953	biological_process	acute-phase response
C	0030246	molecular_function	carbohydrate binding
C	0042802	molecular_function	identical protein binding
C	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
C	0045087	biological_process	innate immune response
C	0045656	biological_process	negative regulation of monocyte differentiation
C	0046597	biological_process	host-mediated suppression of symbiont invasion
C	0046790	molecular_function	virion binding
C	0046872	molecular_function	metal ion binding
C	0048525	biological_process	negative regulation of viral process
C	0051082	molecular_function	unfolded protein binding
C	0051131	biological_process	chaperone-mediated protein complex assembly
C	0061045	biological_process	negative regulation of wound healing
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
C	1903019	biological_process	negative regulation of glycoprotein metabolic process
D	0001849	molecular_function	complement component C1q complex binding
D	0002674	biological_process	negative regulation of acute inflammatory response
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0006457	biological_process	protein folding
D	0006953	biological_process	acute-phase response
D	0030246	molecular_function	carbohydrate binding
D	0042802	molecular_function	identical protein binding
D	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
D	0045087	biological_process	innate immune response
D	0045656	biological_process	negative regulation of monocyte differentiation
D	0046597	biological_process	host-mediated suppression of symbiont invasion
D	0046790	molecular_function	virion binding
D	0046872	molecular_function	metal ion binding
D	0048525	biological_process	negative regulation of viral process
D	0051082	molecular_function	unfolded protein binding
D	0051131	biological_process	chaperone-mediated protein complex assembly
D	0061045	biological_process	negative regulation of wound healing
D	0070062	cellular_component	extracellular exosome
D	0072562	cellular_component	blood microparticle
D	1903019	biological_process	negative regulation of glycoprotein metabolic process
E	0001849	molecular_function	complement component C1q complex binding
E	0002674	biological_process	negative regulation of acute inflammatory response
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0006457	biological_process	protein folding
E	0006953	biological_process	acute-phase response
E	0030246	molecular_function	carbohydrate binding
E	0042802	molecular_function	identical protein binding
E	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
E	0045087	biological_process	innate immune response
E	0045656	biological_process	negative regulation of monocyte differentiation
E	0046597	biological_process	host-mediated suppression of symbiont invasion
E	0046790	molecular_function	virion binding
E	0046872	molecular_function	metal ion binding
E	0048525	biological_process	negative regulation of viral process
E	0051082	molecular_function	unfolded protein binding
E	0051131	biological_process	chaperone-mediated protein complex assembly
E	0061045	biological_process	negative regulation of wound healing
E	0070062	cellular_component	extracellular exosome
E	0072562	cellular_component	blood microparticle
E	1903019	biological_process	negative regulation of glycoprotein metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00289
Number of Residues	8
Details	PTX_1 Pentraxin domain signature. HiCvSWeS

Chain	Residue	Details
A	HIS93-SER100

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	995
Details	Domain: {"description":"Pentraxin (PTX)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000169","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	79
Details	Domain: {"description":"Ig-like C2-type 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	82
Details	Domain: {"description":"Ig-like C2-type 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10397151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---