3D4J

Crystal structure of Human mevalonate diphosphate decarboxylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004163	molecular_function	diphosphomevalonate decarboxylase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006695	biological_process	cholesterol biosynthetic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016126	biological_process	sterol biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
A	0030544	molecular_function	Hsp70 protein binding
A	0042803	molecular_function	protein homodimerization activity
B	0000166	molecular_function	nucleotide binding
B	0004163	molecular_function	diphosphomevalonate decarboxylase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005777	cellular_component	peroxisome
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0006695	biological_process	cholesterol biosynthetic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016126	biological_process	sterol biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
B	0030544	molecular_function	Hsp70 protein binding
B	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 401

Chain	Residue
A	TYR23
A	LYS26
A	VAL32
A	ARG78
A	SER156
A	GLY157
A	THR212

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 402

Chain	Residue
B	ARG78
B	SER156
B	GLY157
B	THR212
B	HOH545
B	TYR23
B	LYS26

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O23722","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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