3D36

How to Switch Off a Histidine Kinase: Crystal Structure of Geobacillus stearothermophilus KinB with the Inhibitor Sda

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000155	molecular_function	phosphorelay sensor kinase activity
A	0007165	biological_process	signal transduction
A	0016310	biological_process	phosphorylation
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0000155	molecular_function	phosphorelay sensor kinase activity
B	0007165	biological_process	signal transduction
B	0016310	biological_process	phosphorylation
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG B 477

Chain	Residue
B	ASN324

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 478

Chain	Residue
A	ASN324

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site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP A 500

Chain	Residue
A	THR371
A	THR372
A	LYS373
A	GLY377
A	THR378
A	GLY379
A	LEU380
A	GLY381
A	MET382
A	THR406
A	ASN324
A	ALA328
A	ASP352
A	GLY356
A	MET357
A	LEU365
A	PHE370

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site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP B 500

Chain	Residue
B	ASN324
B	ALA328
B	ASP352
B	GLY356
B	MET357
B	LEU365
B	PHE370
B	THR371
B	THR372
B	LYS373
B	THR378
B	GLY379
B	LEU380
B	GLY381
B	MET382
B	THR406

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD B 700

Chain	Residue
B	GLY224
B	PHE225

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site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD C 701

Chain	Residue
A	ASP237
A	LYS238
A	GLN241
B	GLU199
B	ARG397
B	TYR411
C	SER5
C	LEU8

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site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD B 702

Chain	Residue
B	ILE211
B	TYR260

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site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD B 703

Chain	Residue
A	ILE211
A	TYR260
B	PRO266

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