3D04

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with sakuranetin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0005737	cellular_component	cytoplasm
B	0006629	biological_process	lipid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0009245	biological_process	lipid A biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016836	molecular_function	hydro-lyase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C	0005737	cellular_component	cytoplasm
C	0006629	biological_process	lipid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0009245	biological_process	lipid A biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016836	molecular_function	hydro-lyase activity
C	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
D	0005737	cellular_component	cytoplasm
D	0006629	biological_process	lipid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0009245	biological_process	lipid A biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016836	molecular_function	hydro-lyase activity
D	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0005737	cellular_component	cytoplasm
E	0006629	biological_process	lipid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0009245	biological_process	lipid A biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016836	molecular_function	hydro-lyase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
F	0005737	cellular_component	cytoplasm
F	0006629	biological_process	lipid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0009245	biological_process	lipid A biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016836	molecular_function	hydro-lyase activity
F	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 160

Chain	Residue
A	HIS58
A	GLY67
A	SAK163

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 160

Chain	Residue
A	HOH164
B	HIS58
B	GLY67

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 160

Chain	Residue
C	GLY67

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 160

Chain	Residue
D	HIS58
D	GLY67

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site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 160

Chain	Residue
E	GLY67

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL F 160

Chain	Residue
F	GLY67

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site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BEN A 161

Chain	Residue
A	GLN40
A	GLU124
A	VAL125
E	THR138
E	GLU148
E	BEN162

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BEN A 162

Chain	Residue
A	THR138
A	GLU148
E	GLN40
E	GLU124
E	VAL125
E	HOH307

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site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SAK A 163

Chain	Residue
A	PHE59
A	PHE109
A	ARG110
A	ILE111
A	PRO112
A	CL160
B	ILE98
B	TYR100
B	ARG158

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BEN C 161

Chain	Residue
C	ALA38
C	THR84
C	SER85
C	LEU86
C	TRP87
C	GLY88
D	GLN40

---

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAK C 162

Chain	Residue
C	ILE20
C	PRO22
C	HIS23
C	PHE83
C	LYS97
C	ILE98
C	VAL99
C	ARG158
C	HOH215
D	PHE59
D	LYS62
D	ILE64

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BEN E 161

Chain	Residue
B	TRP87
B	GLY88
E	LEU86
E	TRP87
E	MET131
E	HOH305

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site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BEN E 162

Chain	Residue
A	GLU150
A	BEN161
E	GLY136
E	GLY137
E	ALA149
E	GLU150

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BEN F 161

Chain	Residue
A	MET131
A	MET154
F	TRP87
F	ASP90
F	ILE93

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