3CZM
T. Gondii bradyzoite-specific LDH (LDH2) in complex with NAD and OXQ
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD A 401 |
| Chain | Residue |
| A | GLY29 |
| A | GLY99 |
| A | LEU100 |
| A | THR101 |
| A | ILE119 |
| A | GLU122 |
| A | VAL138 |
| A | ASN140 |
| A | MET163 |
| A | LEU167 |
| A | HIS195 |
| A | MET30 |
| A | ALA246 |
| A | OXQ708 |
| A | HOH717 |
| A | HOH722 |
| A | HOH765 |
| A | HOH802 |
| A | HOH817 |
| A | HOH826 |
| A | ILE31 |
| A | ASP53 |
| A | VAL54 |
| A | VAL55 |
| A | MET58 |
| A | THR97 |
| A | ALA98 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OXQ A 708 |
| Chain | Residue |
| A | TRP107 |
| A | ARG109 |
| A | ASN140 |
| A | ARG171 |
| A | HIS195 |
| A | GLY236 |
| A | SER245 |
| A | NAD401 |
| A | HOH740 |
| A | HOH826 |
| site_id | AC3 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD B 501 |
| Chain | Residue |
| B | GLY29 |
| B | MET30 |
| B | ILE31 |
| B | PHE52 |
| B | ASP53 |
| B | VAL54 |
| B | VAL55 |
| B | MET58 |
| B | THR97 |
| B | ALA98 |
| B | GLY99 |
| B | LEU100 |
| B | THR101 |
| B | ILE119 |
| B | GLU122 |
| B | VAL138 |
| B | ASN140 |
| B | MET163 |
| B | LEU167 |
| B | HIS195 |
| B | ALA246 |
| B | OXQ706 |
| B | HOH759 |
| B | HOH760 |
| B | HOH764 |
| B | HOH774 |
| B | HOH857 |
| B | HOH869 |
| B | HOH887 |
| B | HOH890 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE OXQ B 706 |
| Chain | Residue |
| B | TRP107 |
| B | ARG109 |
| B | ASN140 |
| B | ARG171 |
| B | HIS195 |
| B | GLY236 |
| B | SER245 |
| B | ALA246 |
| B | NAD501 |
| B | HOH760 |
| B | HOH781 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | HIS195 | |
| A | ASP168 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| B | HIS195 | |
| B | ASP168 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | HIS195 | |
| A | ARG171 | |
| A | ASP168 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| B | HIS195 | |
| B | ARG171 | |
| B | ASP168 |
