Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0007165 | biological_process | signal transduction |
| A | 0007399 | biological_process | nervous system development |
| A | 0008045 | biological_process | motor neuron axon guidance |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043547 | biological_process | positive regulation of GTPase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046875 | molecular_function | ephrin receptor binding |
| A | 0048013 | biological_process | ephrin receptor signaling pathway |
| A | 0050770 | biological_process | regulation of axonogenesis |
| A | 0051056 | biological_process | regulation of small GTPase mediated signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 500 |
| Chain | Residue |
| A | HIS206 |
| A | CYS236 |
| A | CYS239 |
| A | CYS255 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | CYS219 |
| A | CYS222 |
| A | HIS244 |
| A | CYS247 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 503 |
| Chain | Residue |
| A | LYS108 |
| A | GLU107 |
Functional Information from PROSITE/UniProt
| site_id | PS00479 |
| Number of Residues | 50 |
| Details | ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFkvhtfrgphw.CeyCanfMwgliaqgvk.CadCglnvHkqCskmvpnd..C |
| Chain | Residue | Details |
| A | HIS206-CYS255 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 86 |
| Details | Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 191 |
| Details | Domain: {"description":"Rho-GAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00172","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | Zinc finger: {"description":"Phorbol-ester/DAG-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00226","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state","evidences":[{"source":"PROSITE-ProRule","id":"PRU00172","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P30337","evidenceCode":"ECO:0000250"}]} |
