3CXL

Crystal structure of human chimerin 1 (CHN1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0007165	biological_process	signal transduction
A	0007399	biological_process	nervous system development
A	0008045	biological_process	motor neuron axon guidance
A	0043547	biological_process	positive regulation of GTPase activity
A	0046872	molecular_function	metal ion binding
A	0046875	molecular_function	ephrin receptor binding
A	0048013	biological_process	ephrin receptor signaling pathway
A	0050770	biological_process	regulation of axonogenesis
A	0051056	biological_process	regulation of small GTPase mediated signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 500

Chain	Residue
A	HIS206
A	CYS236
A	CYS239
A	CYS255

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS219
A	CYS222
A	HIS244
A	CYS247

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 503

Chain	Residue
A	LYS108
A	GLU107

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Functional Information from PROSITE/UniProt

site_id	PS00479
Number of Residues	50
Details	ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFkvhtfrgphw.CeyCanfMwgliaqgvk.CadCglnvHkqCskmvpnd..C

Chain	Residue	Details
A	HIS206-CYS255

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	ZN_FING: Phorbol-ester/DAG-type => ECO:0000255|PROSITE-ProRule:PRU00226

Chain	Residue	Details
A	ILE205-CYS255

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR192

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P30337

Chain	Residue	Details
A	THR340

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